Results for JAK2

General Information

Gene ID 3717
Gene Symbol JAK2
Gene Name Janus kinase 2
Gene Type protein-coding
Cytoband 9p24
Ensembl ID ENSG00000096968
#miR regulators 10
Omim ID 133100 147796 254450 263300 600880 601626 614521
Gene ontology GO:0000186: activation of MAPKK activity
GO:0007596: blood coagulation
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0035556: intracellular signal transduction
GO:0006468: protein phosphorylation
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006928: cellular component movement
GO:0007167: enzyme linked receptor protein signaling pathway
GO:0007186: G-protein coupled receptor signaling pathway
GO:0007204: elevation of cytosolic calcium ion concentration
GO:0007243: intracellular protein kinase cascade
GO:0007259: JAK-STAT cascade
GO:0007260: tyrosine phosphorylation of STAT protein
GO:0007262: STAT protein import into nucleus
GO:0007498: mesoderm development
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008631: intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0030041: actin filament polymerization
GO:0009755: hormone-mediated signaling pathway
GO:0010811: positive regulation of cell-substrate adhesion
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046677: response to antibiotic
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0019221: cytokine-mediated signaling pathway
GO:0022408: negative regulation of cell-cell adhesion
GO:0030154: cell differentiation
GO:0030218: erythrocyte differentiation
GO:0030335: positive regulation of cell migration
GO:0031103: axon regeneration
GO:0031959: mineralocorticoid receptor signaling pathway
GO:0032024: positive regulation of insulin secretion
GO:0032496: response to lipopolysaccharide
GO:0032516: positive regulation of phosphoprotein phosphatase activity
GO:0032731: positive regulation of interleukin-1 beta production
GO:0032760: positive regulation of tumor necrosis factor production
GO:0033160: positive regulation of protein import into nucleus, translocation
GO:0033194: response to hydroperoxide
GO:0033209: tumor necrosis factor-mediated signaling pathway
GO:0034612: response to tumor necrosis factor
GO:0035409: histone H3-Y41 phosphorylation
GO:0035722: interleukin-12-mediated signaling pathway
GO:0042503: tyrosine phosphorylation of Stat3 protein
GO:0042506: tyrosine phosphorylation of Stat5 protein
GO:0042508: tyrosine phosphorylation of Stat1 protein
GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523: positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042977: activation of JAK2 kinase activity
GO:0043065: positive regulation of apoptotic process
GO:0043388: positive regulation of DNA binding
GO:0043392: negative regulation of DNA binding
GO:0043524: negative regulation of neuron apoptotic process
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045597: positive regulation of cell differentiation
GO:0045822: negative regulation of heart contraction
GO:0046777: protein autophosphorylation
GO:0048008: platelet-derived growth factor receptor signaling pathway
GO:0050727: regulation of inflammatory response
GO:0050729: positive regulation of inflammatory response
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050867: positive regulation of cell activation
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051770: positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333: interferon-gamma-mediated signaling pathway
GO:0060334: regulation of interferon-gamma-mediated signaling pathway
GO:0060396: growth hormone receptor signaling pathway
GO:0060397: JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060399: positive regulation of growth hormone receptor signaling pathway
GO:0061180: mammary gland epithelium development
GO:0070671: response to interleukin-12
GO:0097191: extrinsic apoptotic signaling pathway
GO:0097296: activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005856: cytoskeleton
GO:0005901: caveola
GO:0012505: endomembrane system
GO:0016363: nuclear matrix
GO:0031904: endosome lumen
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0042393: histone binding
GO:0005102: receptor binding
GO:0004672: protein kinase activity
GO:0004713: protein tyrosine kinase activity
GO:0004715: non-membrane spanning protein tyrosine kinase activity
GO:0005131: growth hormone receptor binding
GO:0005143: interleukin-12 receptor binding
GO:0005524: ATP binding
GO:0008022: protein C-terminus binding
GO:0019901: protein kinase binding
GO:0020037: heme binding
GO:0031702: type 1 angiotensin receptor binding
GO:0033130: acetylcholine receptor binding
GO:0035401: histone kinase activity (H3-Y41 specific)
GO:0042169: SH2 domain binding
GO:0043548: phosphatidylinositol 3-kinase binding
GO:0043560: insulin receptor substrate binding
GO:0051428: peptide hormone receptor binding
KEGG pathways 4062: Chemokine signaling pathway
4630: Jak-STAT signaling pathway
4920: Adipocytokine signaling pathway
5140: Leishmaniasis
5145: Toxoplasmosis

PubMed abstracts associated with JAK2

PMID Title Tumor Value
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
title all all