Results for JUN

General Information

Gene ID 3725
Gene Symbol JUN
Gene Name jun proto-oncogene
Gene Type protein-coding
Cytoband 1p32-p31
Ensembl ID ENSG00000177606
#miR regulators 4
Omim ID 165160
Gene ontology GO:0001525: angiogenesis
GO:0001774: microglial cell activation
GO:0001836: release of cytochrome c from mitochondria
GO:0001889: liver development
GO:0001938: positive regulation of endothelial cell proliferation
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0003151: outflow tract morphogenesis
GO:0051726: regulation of cell cycle
GO:0009612: response to mechanical stimulus
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007184: SMAD protein import into nucleus
GO:0007568: aging
GO:0007612: learning
GO:0007623: circadian rhythm
GO:0008285: negative regulation of cell proliferation
GO:0009314: response to radiation
GO:0042493: response to drug
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0030224: monocyte differentiation
GO:0031103: axon regeneration
GO:0031953: negative regulation of protein autophosphorylation
GO:0032321: positive regulation of Rho GTPase activity
GO:0032496: response to lipopolysaccharide
GO:0034097: response to cytokine stimulus
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035026: leading edge cell differentiation
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0042542: response to hydrogen peroxide
GO:0043392: negative regulation of DNA binding
GO:0043524: negative regulation of neuron apoptotic process
GO:0043525: positive regulation of neuron apoptotic process
GO:0043922: negative regulation by host of viral transcription
GO:0043923: positive regulation by host of viral transcription
GO:0045087: innate immune response
GO:0045657: positive regulation of monocyte differentiation
GO:0045740: positive regulation of DNA replication
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048146: positive regulation of fibroblast proliferation
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0051090: regulation of sequence-specific DNA binding transcription factor activity
GO:0051365: cellular response to potassium ion starvation
GO:0051403: stress-activated MAPK cascade
GO:0051591: response to cAMP
GO:0051899: membrane depolarization
GO:0060395: SMAD protein signal transduction
GO:0071277: cellular response to calcium ion
GO:0000228: nuclear chromosome
GO:0005829: cytosol
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005719: nuclear euchromatin
GO:0017053: transcriptional repressor complex
GO:0005515: protein binding
GO:0000980: RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102: RNA polymerase II activating transcription factor binding
GO:0001190: RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677: DNA binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713: transcription coactivator activity
GO:0005100: Rho GTPase activator activity
GO:0008134: transcription factor binding
GO:0044212: transcription regulatory region DNA binding
GO:0035497: cAMP response element binding
GO:0070412: R-SMAD binding
GO:0071837: HMG box domain binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4310: Wnt signaling pathway
4380: Osteoclast differentiation
4510: Focal adhesion
4620: Toll-like receptor signaling pathway
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4722: Neurotrophin signaling pathway
4912: GnRH signaling pathway
5120: Epithelial cell signaling in Helicobacter pylori infection
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5323: Rheumatoid arthritis

PubMed abstracts associated with JUN

PMID Title Tumor Value
8281940 Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. no no
9258335 Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. no no
9443071 Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. no no
9672192 Immunohistochemical detection of c-fos and c-jun expression in osseous and cartilaginous tumours of the skeleton. yes yes
10411143 Expression and regulation of the meprin beta gene in human cancer cells. no no
10453987 Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells. no no
11418138 pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. no no
11746520 Cellular and molecular properties associated with osteosarcoma cells. yes no
12689679 Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. yes yes
14682477 Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
16167336 Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. no no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no
18414033 Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. no no
18645001 c-Jun knockdown sensitizes osteosarcoma to doxorubicin. yes no
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
18986328 Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. no no
21145881 Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways. no no
21640141 Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells. no no
22128168 Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. no no
22939995 IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. yes no
title all all