Results for KDR

General Information

Gene ID 3791
Gene Symbol KDR
Gene Name kinase insert domain receptor (a type III receptor tyrosine kinase)
Gene Type protein-coding
Cytoband 4q11-q12
Ensembl ID ENSG00000128052
#miR regulators 13
Omim ID 191306
Gene ontology GO:0001525: angiogenesis
GO:0001541: ovarian follicle development
GO:0001570: vasculogenesis
GO:0001934: positive regulation of protein phosphorylation
GO:0001938: positive regulation of endothelial cell proliferation
GO:0001945: lymph vessel development
GO:0002042: cell migration involved in sprouting angiogenesis
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0003158: endothelium development
GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008360: regulation of cell shape
GO:0010595: positive regulation of endothelial cell migration
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0019048: modulation by virus of host morphology or physiology
GO:0023014: signal transduction by phosphorylation
GO:0030335: positive regulation of cell migration
GO:0035162: embryonic hemopoiesis
GO:0035584: calcium-mediated signaling using intracellular calcium source
GO:0035924: cellular response to vascular endothelial growth factor stimulus
GO:0038083: peptidyl-tyrosine autophosphorylation
GO:0043129: surfactant homeostasis
GO:0043410: positive regulation of MAPK cascade
GO:0045165: cell fate commitment
GO:0045446: endothelial cell differentiation
GO:0045766: positive regulation of angiogenesis
GO:0046777: protein autophosphorylation
GO:0048010: vascular endothelial growth factor receptor signaling pathway
GO:0048286: lung alveolus development
GO:0048469: cell maturation
GO:0048754: branching morphogenesis of an epithelial tube
GO:0050927: positive regulation of positive chemotaxis
GO:0051770: positive regulation of nitric-oxide synthase biosynthetic process
GO:0051894: positive regulation of focal adhesion assembly
GO:0055074: calcium ion homeostasis
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:2000352: negative regulation of endothelial cell apoptotic process
GO:2001214: positive regulation of vasculogenesis
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0005634: nucleus
GO:0005768: endosome
GO:0005769: early endosome
GO:0005794: Golgi apparatus
GO:0009897: external side of plasma membrane
GO:0016023: cytoplasmic membrane-bounded vesicle
GO:0030054: cell junction
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0004713: protein tyrosine kinase activity
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0004716: receptor signaling protein tyrosine kinase activity
GO:0019838: growth factor binding
GO:0005021: vascular endothelial growth factor-activated receptor activity
GO:0005178: integrin binding
GO:0005524: ATP binding
GO:0051879: Hsp90 protein binding
GO:0038085: vascular endothelial growth factor binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4144: Endocytosis
4370: VEGF signaling pathway
4510: Focal adhesion

PubMed abstracts associated with KDR

PMID Title Tumor Value
10533453 Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. yes yes
17120184 Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. no no
title all all