General Information
Gene ID | 3791 |
---|---|
Gene Symbol | KDR |
Gene Name | kinase insert domain receptor (a type III receptor tyrosine kinase) |
Gene Type | protein-coding |
Cytoband | 4q11-q12 |
Ensembl ID | ENSG00000128052 |
#miR regulators | 13 |
Omim ID | 191306 |
Gene ontology |
GO:0001525: angiogenesis GO:0001541: ovarian follicle development GO:0001570: vasculogenesis GO:0001934: positive regulation of protein phosphorylation GO:0001938: positive regulation of endothelial cell proliferation GO:0001945: lymph vessel development GO:0002042: cell migration involved in sprouting angiogenesis GO:0002053: positive regulation of mesenchymal cell proliferation GO:0003158: endothelium development GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0008360: regulation of cell shape GO:0010595: positive regulation of endothelial cell migration GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0018108: peptidyl-tyrosine phosphorylation GO:0019048: modulation by virus of host morphology or physiology GO:0023014: signal transduction by phosphorylation GO:0030335: positive regulation of cell migration GO:0035162: embryonic hemopoiesis GO:0035584: calcium-mediated signaling using intracellular calcium source GO:0035924: cellular response to vascular endothelial growth factor stimulus GO:0038083: peptidyl-tyrosine autophosphorylation GO:0043129: surfactant homeostasis GO:0043410: positive regulation of MAPK cascade GO:0045165: cell fate commitment GO:0045446: endothelial cell differentiation GO:0045766: positive regulation of angiogenesis GO:0046777: protein autophosphorylation GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0048286: lung alveolus development GO:0048469: cell maturation GO:0048754: branching morphogenesis of an epithelial tube GO:0050927: positive regulation of positive chemotaxis GO:0051770: positive regulation of nitric-oxide synthase biosynthetic process GO:0051894: positive regulation of focal adhesion assembly GO:0055074: calcium ion homeostasis GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:2000352: negative regulation of endothelial cell apoptotic process GO:2001214: positive regulation of vasculogenesis GO:0005886: plasma membrane GO:0005576: extracellular region GO:0005887: integral to plasma membrane GO:0005634: nucleus GO:0005768: endosome GO:0005769: early endosome GO:0005794: Golgi apparatus GO:0009897: external side of plasma membrane GO:0016023: cytoplasmic membrane-bounded vesicle GO:0030054: cell junction GO:0045121: membrane raft GO:0005515: protein binding GO:0004713: protein tyrosine kinase activity GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0004716: receptor signaling protein tyrosine kinase activity GO:0019838: growth factor binding GO:0005021: vascular endothelial growth factor-activated receptor activity GO:0005178: integrin binding GO:0005524: ATP binding GO:0051879: Hsp90 protein binding GO:0038085: vascular endothelial growth factor binding |
KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4144: Endocytosis 4370: VEGF signaling pathway 4510: Focal adhesion |
PMID | Title | Tumor | Value |
---|---|---|---|
10533453 | Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. | yes | yes |
17120184 | Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. | no | no |
title | all | all |