Results for KIT

General Information

Gene ID 3815
Gene Symbol KIT
Gene Name v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Gene Type protein-coding
Cytoband 4q11-q12
Ensembl ID ENSG00000157404
#miR regulators 14
Omim ID 154800 164920 172800 601626 606764
Gene ontology GO:0000187: activation of MAPK activity
GO:0001541: ovarian follicle development
GO:0002318: myeloid progenitor cell differentiation
GO:0002320: lymphoid progenitor cell differentiation
GO:0002327: immature B cell differentiation
GO:0002371: dendritic cell cytokine production
GO:0002551: mast cell chemotaxis
GO:0007165: signal transduction
GO:0006687: glycosphingolipid metabolic process
GO:0006954: inflammatory response
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007243: intracellular protein kinase cascade
GO:0007283: spermatogenesis
GO:0007286: spermatid development
GO:0008284: positive regulation of cell proliferation
GO:0008360: regulation of cell shape
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0008584: male gonad development
GO:0009314: response to radiation
GO:0010628: positive regulation of gene expression
GO:0010863: positive regulation of phospholipase C activity
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0019221: cytokine-mediated signaling pathway
GO:0019827: stem cell maintenance
GO:0048015: phosphatidylinositol-mediated signaling
GO:0023014: signal transduction by phosphorylation
GO:0030032: lamellipodium assembly
GO:0030097: hemopoiesis
GO:0030217: T cell differentiation
GO:0030218: erythrocyte differentiation
GO:0030318: melanocyte differentiation
GO:0031532: actin cytoskeleton reorganization
GO:0032762: mast cell cytokine production
GO:0035162: embryonic hemopoiesis
GO:0035234: germ cell programmed cell death
GO:0035855: megakaryocyte development
GO:0038093: Fc receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038109: Kit signaling pathway
GO:0038162: erythropoietin-mediated signaling pathway
GO:0042127: regulation of cell proliferation
GO:0042511: positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523: positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043069: negative regulation of programmed cell death
GO:0043303: mast cell degranulation
GO:0043410: positive regulation of MAPK cascade
GO:0043473: pigmentation
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087: innate immune response
GO:0046427: positive regulation of JAK-STAT cascade
GO:0046777: protein autophosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048070: regulation of developmental pigmentation
GO:0048565: digestive tract development
GO:0048863: stem cell differentiation
GO:0050910: detection of mechanical stimulus involved in sensory perception of sound
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060326: cell chemotaxis
GO:0060374: mast cell differentiation
GO:0070662: mast cell proliferation
GO:0097067: cellular response to thyroid hormone stimulus
GO:0097324: melanocyte migration
GO:0097326: melanocyte adhesion
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0009897: external side of plasma membrane
GO:0005515: protein binding
GO:0002020: protease binding
GO:0004713: protein tyrosine kinase activity
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0004716: receptor signaling protein tyrosine kinase activity
GO:0005020: stem cell factor receptor activity
GO:0046872: metal ion binding
GO:0005524: ATP binding
GO:0019955: cytokine binding
GO:0042803: protein homodimerization activity
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4144: Endocytosis
4640: Hematopoietic cell lineage
4916: Melanogenesis
5200: Pathways in cancer
5221: Acute myeloid leukemia

PubMed abstracts associated with KIT

PMID Title Tumor Value
11914627 C-kit expression in pediatric solid tumors: a comparative immunohistochemical study. yes no
12912938 Clinicopathologic assessment of postradiation sarcomas: KIT as a potential treatment target. yes no
15800315 Prognostic significance of allelic imbalance at the c-kit gene locus and c-kit overexpression by immunohistochemistry in pediatric osteosarcomas. yes yes
15900593 Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. yes yes
17018686 Expression of c-kit in human osteosarcoma and its relevance as a prognostic marker. yes yes
17294449 KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? yes no
18831895 Expression of c-kit protein and mutational status of the c-kit gene in osteosarcoma and their clinicopathological significance. yes yes
20460510 CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. no no
22135725 C-kit expression in human osteosarcoma and in vitro assays. yes no
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