General Information
| Gene ID | 3845 |
|---|---|
| Gene Symbol | KRAS |
| Gene Name | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
| Gene Type | protein-coding |
| Cytoband | 12p12.1 |
| Ensembl ID | ENSG00000133703 |
| #miR regulators | 11 |
| Omim ID | 109800 114480 137215 163200 190070 211980 260350 609942 615278 |
| Gene ontology |
GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0001934: positive regulation of protein phosphorylation GO:0030036: actin cytoskeleton organization GO:0007596: blood coagulation GO:0007173: epidermal growth factor receptor signaling pathway GO:0007264: small GTPase mediated signal transduction GO:0007265: Ras protein signal transduction GO:0007411: axon guidance GO:0008284: positive regulation of cell proliferation GO:0008286: insulin receptor signaling pathway GO:0008542: visual learning GO:0008543: fibroblast growth factor receptor signaling pathway GO:0010628: positive regulation of gene expression GO:0019221: cytokine-mediated signaling pathway GO:0032228: regulation of synaptic transmission, GABAergic GO:0035022: positive regulation of Rac protein signal transduction GO:0035176: social behavior GO:0038095: Fc-epsilon receptor signaling pathway GO:0043406: positive regulation of MAP kinase activity GO:0043524: negative regulation of neuron apoptotic process GO:0045087: innate immune response GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048169: regulation of long-term neuronal synaptic plasticity GO:0050900: leukocyte migration GO:0051000: positive regulation of nitric-oxide synthase activity GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0051146: striated muscle cell differentiation GO:0051384: response to glucocorticoid stimulus GO:0051385: response to mineralocorticoid stimulus GO:0005886: plasma membrane GO:0005739: mitochondrion GO:0045121: membrane raft GO:0005515: protein binding GO:0003924: GTPase activity GO:0005525: GTP binding GO:0019002: GMP binding GO:0019003: GDP binding GO:0030275: LRR domain binding |
| KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4320: Dorso-ventral axis formation 4360: Axon guidance 4370: VEGF signaling pathway 4530: Tight junction 4540: Gap junction 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4720: Long-term potentiation 4722: Neurotrophin signaling pathway 4730: Long-term depression 4810: Regulation of actin cytoskeleton 4910: Insulin signaling pathway 4912: GnRH signaling pathway 4914: Progesterone-mediated oocyte maturation 4916: Melanogenesis 4960: Aldosterone-regulated sodium reabsorption 5160: Hepatitis C 5200: Pathways in cancer 5210: Colorectal cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5216: Thyroid cancer 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5223: Non-small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 7850751 | Mutational activation of ras genes is absent in pediatric osteosarcoma. | yes | no |
| 15492501 | Differential oncogenic Ras signaling and senescence in tumor cells. | no | no |
| 20406948 | Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. | no | no |
| 22006429 | High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. | yes | no |
| title | all | all |