Results for KRAS

General Information

Gene ID 3845
Gene Symbol KRAS
Gene Name v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Gene Type protein-coding
Cytoband 12p12.1
Ensembl ID ENSG00000133703
#miR regulators 11
Omim ID 109800 114480 137215 163200 190070 211980 260350 609942 615278
Gene ontology GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0001934: positive regulation of protein phosphorylation
GO:0030036: actin cytoskeleton organization
GO:0007596: blood coagulation
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007264: small GTPase mediated signal transduction
GO:0007265: Ras protein signal transduction
GO:0007411: axon guidance
GO:0008284: positive regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0008542: visual learning
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010628: positive regulation of gene expression
GO:0019221: cytokine-mediated signaling pathway
GO:0032228: regulation of synaptic transmission, GABAergic
GO:0035022: positive regulation of Rac protein signal transduction
GO:0035176: social behavior
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0043406: positive regulation of MAP kinase activity
GO:0043524: negative regulation of neuron apoptotic process
GO:0045087: innate immune response
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048169: regulation of long-term neuronal synaptic plasticity
GO:0050900: leukocyte migration
GO:0051000: positive regulation of nitric-oxide synthase activity
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051146: striated muscle cell differentiation
GO:0051384: response to glucocorticoid stimulus
GO:0051385: response to mineralocorticoid stimulus
GO:0005886: plasma membrane
GO:0005739: mitochondrion
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0003924: GTPase activity
GO:0005525: GTP binding
GO:0019002: GMP binding
GO:0019003: GDP binding
GO:0030275: LRR domain binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4320: Dorso-ventral axis formation
4360: Axon guidance
4370: VEGF signaling pathway
4530: Tight junction
4540: Gap junction
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4720: Long-term potentiation
4722: Neurotrophin signaling pathway
4730: Long-term depression
4810: Regulation of actin cytoskeleton
4910: Insulin signaling pathway
4912: GnRH signaling pathway
4914: Progesterone-mediated oocyte maturation
4916: Melanogenesis
4960: Aldosterone-regulated sodium reabsorption
5160: Hepatitis C
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5216: Thyroid cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5223: Non-small cell lung cancer

PubMed abstracts associated with KRAS

PMID Title Tumor Value
7850751 Mutational activation of ras genes is absent in pediatric osteosarcoma. yes no
15492501 Differential oncogenic Ras signaling and senescence in tumor cells. no no
20406948 Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. no no
22006429 High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. yes no
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