Results for RHOA

General Information

Gene ID 387
Gene Symbol RHOA
Gene Name ras homolog family member A
Gene Type protein-coding
Cytoband 3p21.3
Ensembl ID ENSG00000067560
#miR regulators 5
Omim ID 165390
Gene ontology GO:0001666: response to hypoxia
GO:0030036: actin cytoskeleton organization
GO:0007596: blood coagulation
GO:0006357: regulation of transcription from RNA polymerase II promoter
GO:0009612: response to mechanical stimulus
GO:0007160: cell-matrix adhesion
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007264: small GTPase mediated signal transduction
GO:0007266: Rho protein signal transduction
GO:0007411: axon guidance
GO:0007519: skeletal muscle tissue development
GO:0042493: response to drug
GO:0009749: response to glucose stimulus
GO:0045727: positive regulation of translation
GO:0019048: modulation by virus of host morphology or physiology
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030168: platelet activation
GO:0030307: positive regulation of cell growth
GO:0030334: regulation of cell migration
GO:0030335: positive regulation of cell migration
GO:0030521: androgen receptor signaling pathway
GO:0030838: positive regulation of actin filament polymerization
GO:0031098: stress-activated protein kinase signaling cascade
GO:0032467: positive regulation of cytokinesis
GO:0033144: negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033688: regulation of osteoblast proliferation
GO:0036089: cleavage furrow formation
GO:0042346: positive regulation of NF-kappaB import into nucleus
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043124: negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043149: stress fiber assembly
GO:0043200: response to amino acid stimulus
GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043297: apical junction assembly
GO:0043524: negative regulation of neuron apoptotic process
GO:0043525: positive regulation of neuron apoptotic process
GO:0043931: ossification involved in bone maturation
GO:0045471: response to ethanol
GO:0045665: negative regulation of neuron differentiation
GO:0045666: positive regulation of neuron differentiation
GO:0045785: positive regulation of cell adhesion
GO:0045907: positive regulation of vasoconstriction
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050770: regulation of axonogenesis
GO:0050771: negative regulation of axonogenesis
GO:0050772: positive regulation of axonogenesis
GO:0050773: regulation of dendrite development
GO:0051056: regulation of small GTPase mediated signal transduction
GO:0051384: response to glucocorticoid stimulus
GO:0051496: positive regulation of stress fiber assembly
GO:0051924: regulation of calcium ion transport
GO:0061383: trabecula morphogenesis
GO:0071803: positive regulation of podosome assembly
GO:0090307: spindle assembly involved in mitosis
GO:0005886: plasma membrane
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005856: cytoskeleton
GO:0005938: cell cortex
GO:0030027: lamellipodium
GO:0030054: cell junction
GO:0030424: axon
GO:0030496: midbody
GO:0032154: cleavage furrow
GO:0032587: ruffle membrane
GO:0043296: apical junction complex
GO:0005515: protein binding
GO:0003924: GTPase activity
GO:0005525: GTP binding
GO:0017022: myosin binding
GO:0019904: protein domain specific binding
KEGG pathways 4062: Chemokine signaling pathway
4144: Endocytosis
4270: Vascular smooth muscle contraction
4310: Wnt signaling pathway
4350: TGF-beta signaling pathway
4360: Axon guidance
4510: Focal adhesion
4520: Adherens junction
4530: Tight junction
4660: T cell receptor signaling pathway
4670: Leukocyte transendothelial migration
4722: Neurotrophin signaling pathway
4810: Regulation of actin cytoskeleton
4972: Pancreatic secretion
5100: Bacterial invasion of epithelial cells
5130: Pathogenic Escherichia coli infection
5200: Pathways in cancer
5210: Colorectal cancer

PubMed abstracts associated with RHOA

PMID Title Tumor Value
16470222 RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. no no
17660802 Prognostic significance of drug-regulated genes in high-grade osteosarcoma. yes yes
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
20530678 High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells. no no
title all all