General Information
Gene ID | 387 |
---|---|
Gene Symbol | RHOA |
Gene Name | ras homolog family member A |
Gene Type | protein-coding |
Cytoband | 3p21.3 |
Ensembl ID | ENSG00000067560 |
#miR regulators | 5 |
Omim ID | 165390 |
Gene ontology |
GO:0001666: response to hypoxia GO:0030036: actin cytoskeleton organization GO:0007596: blood coagulation GO:0006357: regulation of transcription from RNA polymerase II promoter GO:0009612: response to mechanical stimulus GO:0007160: cell-matrix adhesion GO:0007179: transforming growth factor beta receptor signaling pathway GO:0007264: small GTPase mediated signal transduction GO:0007266: Rho protein signal transduction GO:0007411: axon guidance GO:0007519: skeletal muscle tissue development GO:0042493: response to drug GO:0009749: response to glucose stimulus GO:0045727: positive regulation of translation GO:0019048: modulation by virus of host morphology or physiology GO:0048015: phosphatidylinositol-mediated signaling GO:0030168: platelet activation GO:0030307: positive regulation of cell growth GO:0030334: regulation of cell migration GO:0030335: positive regulation of cell migration GO:0030521: androgen receptor signaling pathway GO:0030838: positive regulation of actin filament polymerization GO:0031098: stress-activated protein kinase signaling cascade GO:0032467: positive regulation of cytokinesis GO:0033144: negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033688: regulation of osteoblast proliferation GO:0036089: cleavage furrow formation GO:0042346: positive regulation of NF-kappaB import into nucleus GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124: negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043149: stress fiber assembly GO:0043200: response to amino acid stimulus GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043297: apical junction assembly GO:0043524: negative regulation of neuron apoptotic process GO:0043525: positive regulation of neuron apoptotic process GO:0043931: ossification involved in bone maturation GO:0045471: response to ethanol GO:0045665: negative regulation of neuron differentiation GO:0045666: positive regulation of neuron differentiation GO:0045785: positive regulation of cell adhesion GO:0045907: positive regulation of vasoconstriction GO:0048011: neurotrophin TRK receptor signaling pathway GO:0050770: regulation of axonogenesis GO:0050771: negative regulation of axonogenesis GO:0050772: positive regulation of axonogenesis GO:0050773: regulation of dendrite development GO:0051056: regulation of small GTPase mediated signal transduction GO:0051384: response to glucocorticoid stimulus GO:0051496: positive regulation of stress fiber assembly GO:0051924: regulation of calcium ion transport GO:0061383: trabecula morphogenesis GO:0071803: positive regulation of podosome assembly GO:0090307: spindle assembly involved in mitosis GO:0005886: plasma membrane GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005856: cytoskeleton GO:0005938: cell cortex GO:0030027: lamellipodium GO:0030054: cell junction GO:0030424: axon GO:0030496: midbody GO:0032154: cleavage furrow GO:0032587: ruffle membrane GO:0043296: apical junction complex GO:0005515: protein binding GO:0003924: GTPase activity GO:0005525: GTP binding GO:0017022: myosin binding GO:0019904: protein domain specific binding |
KEGG pathways |
4062: Chemokine signaling pathway 4144: Endocytosis 4270: Vascular smooth muscle contraction 4310: Wnt signaling pathway 4350: TGF-beta signaling pathway 4360: Axon guidance 4510: Focal adhesion 4520: Adherens junction 4530: Tight junction 4660: T cell receptor signaling pathway 4670: Leukocyte transendothelial migration 4722: Neurotrophin signaling pathway 4810: Regulation of actin cytoskeleton 4972: Pancreatic secretion 5100: Bacterial invasion of epithelial cells 5130: Pathogenic Escherichia coli infection 5200: Pathways in cancer 5210: Colorectal cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
16470222 | RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. | no | no |
17660802 | Prognostic significance of drug-regulated genes in high-grade osteosarcoma. | yes | yes |
18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no |
20530678 | High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells. | no | no |
title | all | all |