Results for LEP

General Information

Gene ID 3952
Gene Symbol LEP
Gene Name leptin
Gene Type protein-coding
Cytoband 7q31.3
Ensembl ID ENSG00000174697
#miR regulators 3
Omim ID 164160 614962
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001542: ovulation from ovarian follicle
GO:0001666: response to hypoxia
GO:0001819: positive regulation of cytokine production
GO:0001890: placenta development
GO:0002021: response to dietary excess
GO:0006006: glucose metabolic process
GO:0006111: regulation of gluconeogenesis
GO:0006112: energy reserve metabolic process
GO:0006114: glycerol biosynthetic process
GO:0007260: tyrosine phosphorylation of STAT protein
GO:0007565: female pregnancy
GO:0007623: circadian rhythm
GO:0050796: regulation of insulin secretion
GO:0050810: regulation of steroid biosynthetic process
GO:0043066: negative regulation of apoptotic process
GO:0008203: cholesterol metabolic process
GO:0008206: bile acid metabolic process
GO:0008217: regulation of blood pressure
GO:0008284: positive regulation of cell proliferation
GO:0008343: adult feeding behavior
GO:0009062: fatty acid catabolic process
GO:0046881: positive regulation of follicle-stimulating hormone secretion
GO:0021954: central nervous system neuron development
GO:0030073: insulin secretion
GO:0030300: regulation of intestinal cholesterol absorption
GO:0032099: negative regulation of appetite
GO:0032868: response to insulin stimulus
GO:0033197: response to vitamin E
GO:0033210: leptin-mediated signaling pathway
GO:0033686: positive regulation of luteinizing hormone secretion
GO:0035630: bone mineralization involved in bone maturation
GO:0042445: hormone metabolic process
GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042755: eating behavior
GO:0043270: positive regulation of ion transport
GO:0043410: positive regulation of MAPK cascade
GO:0045639: positive regulation of myeloid cell differentiation
GO:0045906: negative regulation of vasoconstriction
GO:0046628: positive regulation of insulin receptor signaling pathway
GO:0048639: positive regulation of developmental growth
GO:0050901: leukocyte tethering or rolling
GO:0060587: regulation of lipoprotein lipid oxidation
GO:0060612: adipose tissue development
GO:0061037: negative regulation of cartilage development
GO:0070093: negative regulation of glucagon secretion
GO:0071298: cellular response to L-ascorbic acid
GO:0071300: cellular response to retinoic acid
GO:2000366: positive regulation of STAT protein import into nucleus
GO:2000486: negative regulation of glutamine transport
GO:2000491: positive regulation of hepatic stellate cell activation
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005737: cytoplasm
GO:0005179: hormone activity
GO:0008083: growth factor activity
GO:0051428: peptide hormone receptor binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4080: Neuroactive ligand-receptor interaction
4630: Jak-STAT signaling pathway
4920: Adipocytokine signaling pathway

PubMed abstracts associated with LEP

PMID Title Tumor Value
10977962 Leptin and apoptosis inhibitor soluble Fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors. yes yes
title all all