Results for LRP5

General Information

Gene ID 4041
Gene Symbol LRP5
Gene Name low density lipoprotein receptor-related protein 5
Gene Type protein-coding
Cytoband 11q13.4
Ensembl ID ENSG00000162337
#miR regulators 2
Omim ID 133780 144750 166710 259770 601813 601884 603506 607634 607636
Gene ontology GO:0001702: gastrulation with mouth forming second
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002076: osteoblast development
GO:0016055: Wnt receptor signaling pathway
GO:0006007: glucose catabolic process
GO:0006897: endocytosis
GO:0008217: regulation of blood pressure
GO:0008284: positive regulation of cell proliferation
GO:0009952: anterior/posterior pattern specification
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0030326: embryonic limb morphogenesis
GO:0042632: cholesterol homeostasis
GO:0044332: Wnt receptor signaling pathway involved in dorsal/ventral axis specification
GO:0045600: positive regulation of fat cell differentiation
GO:0045668: negative regulation of osteoblast differentiation
GO:0045840: positive regulation of mitosis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046849: bone remodeling
GO:0048539: bone marrow development
GO:0048596: embryonic camera-type eye morphogenesis
GO:0060042: retina morphogenesis in camera-type eye
GO:0060059: embryonic retina morphogenesis in camera-type eye
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060349: bone morphogenesis
GO:0060444: branching involved in mammary gland duct morphogenesis
GO:0060612: adipose tissue development
GO:0060828: regulation of canonical Wnt receptor signaling pathway
GO:0061178: regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061304: retinal blood vessel morphogenesis
GO:0071901: negative regulation of protein serine/threonine kinase activity
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005783: endoplasmic reticulum
GO:0043235: receptor complex
GO:0005515: protein binding
GO:0042813: Wnt-activated receptor activity
GO:0015026: coreceptor activity
GO:0017147: Wnt-protein binding
KEGG pathways 4310: Wnt signaling pathway

PubMed abstracts associated with LRP5

PMID Title Tumor Value
14735475 Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. yes yes
15087387 Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. no no
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no
title all all