Results for LTA

General Information

Gene ID 4049
Gene Symbol LTA
Gene Name lymphotoxin alpha (TNF superfamily, member 1)
Gene Type protein-coding
Cytoband 6p21.3
Ensembl ID ENSG00000226979 ENSG00000230279 ENSG00000231408 ENSG00000226275 ENSG00000223919 ENSG00000173503 ENSG00000238130
#miR regulators 2
Omim ID 153440 607507 608446 610988
Gene ontology GO:0001666: response to hypoxia
GO:0002876: positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925: positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0007165: signal transduction
GO:0006959: humoral immune response
GO:0007267: cell-cell signaling
GO:0048535: lymph node development
GO:0007584: response to nutrient
GO:0050830: defense response to Gram-positive bacterium
GO:0042493: response to drug
GO:0032496: response to lipopolysaccharide
GO:0032729: positive regulation of interferon-gamma production
GO:0044130: negative regulation of growth of symbiont in host
GO:0048147: negative regulation of fibroblast proliferation
GO:0016020: membrane
GO:0005615: extracellular space
GO:0005102: receptor binding
GO:0005125: cytokine activity
GO:0005164: tumor necrosis factor receptor binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4940: Type I diabetes mellitus

PubMed abstracts associated with LTA

PMID Title Tumor Value
1571831 Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells. no no
9703945 Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells. no no
11089884 Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. no no
12926161 Serum levels of TNF-beta and sTNF-R in patients with malignant bone tumours. yes yes
17483704 TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. yes no
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