General Information
| Gene ID | 4049 |
|---|---|
| Gene Symbol | LTA |
| Gene Name | lymphotoxin alpha (TNF superfamily, member 1) |
| Gene Type | protein-coding |
| Cytoband | 6p21.3 |
| Ensembl ID | ENSG00000226979 ENSG00000230279 ENSG00000231408 ENSG00000226275 ENSG00000223919 ENSG00000173503 ENSG00000238130 |
| #miR regulators | 2 |
| Omim ID | 153440 607507 608446 610988 |
| Gene ontology |
GO:0001666: response to hypoxia GO:0002876: positive regulation of chronic inflammatory response to antigenic stimulus GO:0002925: positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0007165: signal transduction GO:0006959: humoral immune response GO:0007267: cell-cell signaling GO:0048535: lymph node development GO:0007584: response to nutrient GO:0050830: defense response to Gram-positive bacterium GO:0042493: response to drug GO:0032496: response to lipopolysaccharide GO:0032729: positive regulation of interferon-gamma production GO:0044130: negative regulation of growth of symbiont in host GO:0048147: negative regulation of fibroblast proliferation GO:0016020: membrane GO:0005615: extracellular space GO:0005102: receptor binding GO:0005125: cytokine activity GO:0005164: tumor necrosis factor receptor binding |
| KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4940: Type I diabetes mellitus |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 1571831 | Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells. | no | no |
| 9703945 | Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells. | no | no |
| 11089884 | Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. | no | no |
| 12926161 | Serum levels of TNF-beta and sTNF-R in patients with malignant bone tumours. | yes | yes |
| 17483704 | TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. | yes | no |
| title | all | all |