Results for MAD2L1

General Information

Gene ID 4085
Gene Symbol MAD2L1
Gene Name MAD2 mitotic arrest deficient-like 1 (yeast)
Gene Type protein-coding
Cytoband 4q27
Ensembl ID ENSG00000164109
#miR regulators 3
Omim ID 601467
Gene ontology GO:0000070: mitotic sister chromatid segregation
GO:0000278: mitotic cell cycle
GO:0007093: mitotic cell cycle checkpoint
GO:0007094: mitotic spindle assembly checkpoint
GO:0043066: negative regulation of apoptotic process
GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042177: negative regulation of protein catabolic process
GO:0051301: cell division
GO:0051436: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060564: negative regulation of mitotic anaphase-promoting complex activity
GO:0090267: positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0000776: kinetochore
GO:0000777: condensed chromosome kinetochore
GO:0000922: spindle pole
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005643: nuclear pore
GO:0048471: perinuclear region of cytoplasm
GO:0072686: mitotic spindle
GO:0005515: protein binding
GO:0042803: protein homodimerization activity
KEGG pathways 4110: Cell cycle
4114: Oocyte meiosis
4914: Progesterone-mediated oocyte maturation

PubMed abstracts associated with MAD2L1

PMID Title Tumor Value
19778378 U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. no no
20132188 Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma. yes yes
21901524 Knockdown of Mad2 induces osteosarcoma cell apoptosis-involved Rad21 cleavage. no no
title all all