General Information
| Gene ID | 4085 |
|---|---|
| Gene Symbol | MAD2L1 |
| Gene Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
| Gene Type | protein-coding |
| Cytoband | 4q27 |
| Ensembl ID | ENSG00000164109 |
| #miR regulators | 3 |
| Omim ID | 601467 |
| Gene ontology |
GO:0000070: mitotic sister chromatid segregation GO:0000278: mitotic cell cycle GO:0007093: mitotic cell cycle checkpoint GO:0007094: mitotic spindle assembly checkpoint GO:0043066: negative regulation of apoptotic process GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0042177: negative regulation of protein catabolic process GO:0051301: cell division GO:0051436: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0060564: negative regulation of mitotic anaphase-promoting complex activity GO:0090267: positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0000776: kinetochore GO:0000777: condensed chromosome kinetochore GO:0000922: spindle pole GO:0005829: cytosol GO:0005634: nucleus GO:0005643: nuclear pore GO:0048471: perinuclear region of cytoplasm GO:0072686: mitotic spindle GO:0005515: protein binding GO:0042803: protein homodimerization activity |
| KEGG pathways |
4110: Cell cycle 4114: Oocyte meiosis 4914: Progesterone-mediated oocyte maturation |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 19778378 | U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. | no | no |
| 20132188 | Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma. | yes | yes |
| 21901524 | Knockdown of Mad2 induces osteosarcoma cell apoptosis-involved Rad21 cleavage. | no | no |
| title | all | all |