Results for SMAD2

General Information

Gene ID 4087
Gene Symbol SMAD2
Gene Name SMAD family member 2
Gene Type protein-coding
Cytoband 18q21.1
Ensembl ID ENSG00000175387
#miR regulators 8
Omim ID 601366
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001657: ureteric bud development
GO:0001701: in utero embryonic development
GO:0001706: endoderm formation
GO:0001707: mesoderm formation
GO:0035556: intracellular signal transduction
GO:0006351: transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007182: common-partner SMAD protein phosphorylation
GO:0007183: SMAD protein complex assembly
GO:0007352: zygotic specification of dorsal/ventral axis
GO:0007369: gastrulation
GO:0008285: negative regulation of cell proliferation
GO:0009749: response to glucose stimulus
GO:0009791: post-embryonic development
GO:0009952: anterior/posterior pattern specification
GO:0010467: gene expression
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0017015: regulation of transforming growth factor beta receptor signaling pathway
GO:0030073: insulin secretion
GO:0030324: lung development
GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030513: positive regulation of BMP signaling pathway
GO:0031016: pancreas development
GO:0031053: primary miRNA processing
GO:0032924: activin receptor signaling pathway
GO:0035265: organ growth
GO:0038092: nodal signaling pathway
GO:0045165: cell fate commitment
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048340: paraxial mesoderm morphogenesis
GO:0048589: developmental growth
GO:0048617: embryonic foregut morphogenesis
GO:0048701: embryonic cranial skeleton morphogenesis
GO:0051098: regulation of binding
GO:0060021: palate development
GO:0060039: pericardium development
GO:0070723: response to cholesterol
GO:1900224: positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0032444: activin responsive factor complex
GO:0071141: SMAD protein complex
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0003682: chromatin binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0030618: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0005160: transforming growth factor beta receptor binding
GO:0046872: metal ion binding
GO:0008134: transcription factor binding
GO:0019902: phosphatase binding
GO:0031625: ubiquitin protein ligase binding
GO:0033613: activating transcription factor binding
GO:0034713: type I transforming growth factor beta receptor binding
GO:0046332: SMAD binding
GO:0070410: co-SMAD binding
GO:0070411: I-SMAD binding
GO:0070412: R-SMAD binding
KEGG pathways 4110: Cell cycle
4144: Endocytosis
4310: Wnt signaling pathway
4350: TGF-beta signaling pathway
4520: Adherens junction
5142: Chagas disease (American trypanosomiasis)
5200: Pathways in cancer
5210: Colorectal cancer
5212: Pancreatic cancer

PubMed abstracts associated with SMAD2

PMID Title Tumor Value
15174116 Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. no no
18093185 Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells. no no
20350217 Expression of Smad and its signalling cascade in osteosarcoma. yes no
21421073 Lumican regulates osteosarcoma cell adhesion by modulating TGF?2 activity. no no
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