General Information
Gene ID | 4089 |
---|---|
Gene Symbol | SMAD4 |
Gene Name | SMAD family member 4 |
Gene Type | protein-coding |
Cytoband | 18q21.1 |
Ensembl ID | ENSG00000141646 |
#miR regulators | 9 |
Omim ID | 139210 174900 175050 600993 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001658: branching involved in ureteric bud morphogenesis GO:0001666: response to hypoxia GO:0001701: in utero embryonic development GO:0001702: gastrulation with mouth forming second GO:0003190: atrioventricular valve formation GO:0003198: epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003251: positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003279: cardiac septum development GO:0003360: brainstem development GO:0006351: transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0007179: transforming growth factor beta receptor signaling pathway GO:0007183: SMAD protein complex assembly GO:0007411: axon guidance GO:0007492: endoderm development GO:0007498: mesoderm development GO:0008283: cell proliferation GO:0008285: negative regulation of cell proliferation GO:0010467: gene expression GO:0010718: positive regulation of epithelial to mesenchymal transition GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation GO:0014033: neural crest cell differentiation GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0017015: regulation of transforming growth factor beta receptor signaling pathway GO:0030308: negative regulation of cell growth GO:0030509: BMP signaling pathway GO:0030511: positive regulation of transforming growth factor beta receptor signaling pathway GO:0030513: positive regulation of BMP signaling pathway GO:0032525: somite rostral/caudal axis specification GO:0032909: regulation of transforming growth factor beta2 production GO:0036302: atrioventricular canal development GO:0042118: endothelial cell activation GO:0042177: negative regulation of protein catabolic process GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048589: developmental growth GO:0048663: neuron fate commitment GO:0048733: sebaceous gland development GO:0048859: formation of anatomical boundary GO:0051098: regulation of binding GO:0051797: regulation of hair follicle development GO:0060021: palate development GO:0060391: positive regulation of SMAD protein import into nucleus GO:0060395: SMAD protein signal transduction GO:0060548: negative regulation of cell death GO:0060956: endocardial cell differentiation GO:0071559: response to transforming growth factor beta stimulus GO:0072133: metanephric mesenchyme morphogenesis GO:0072134: nephrogenic mesenchyme morphogenesis GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005667: transcription factor complex GO:0005813: centrosome GO:0032444: activin responsive factor complex GO:0071141: SMAD protein complex GO:0005515: protein binding GO:0000987: core promoter proximal region sequence-specific DNA binding GO:0000988: protein binding transcription factor activity GO:0001076: RNA polymerase II transcription factor binding transcription factor activity GO:0001085: RNA polymerase II transcription factor binding GO:0003677: DNA binding GO:0003682: chromatin binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0030616: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity GO:0046872: metal ion binding GO:0005518: collagen binding GO:0042802: identical protein binding GO:0044212: transcription regulatory region DNA binding GO:0042803: protein homodimerization activity GO:0043565: sequence-specific DNA binding GO:0070411: I-SMAD binding GO:0070412: R-SMAD binding |
KEGG pathways |
4110: Cell cycle 4310: Wnt signaling pathway 4350: TGF-beta signaling pathway 4520: Adherens junction 5200: Pathways in cancer 5210: Colorectal cancer 5212: Pancreatic cancer 5220: Chronic myeloid leukemia |
PMID | Title | Tumor | Value |
---|---|---|---|
15174116 | Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. | no | no |
20350217 | Expression of Smad and its signalling cascade in osteosarcoma. | yes | no |
title | all | all |