Results for SMAD4

General Information

Gene ID 4089
Gene Symbol SMAD4
Gene Name SMAD family member 4
Gene Type protein-coding
Cytoband 18q21.1
Ensembl ID ENSG00000141646
#miR regulators 9
Omim ID 139210 174900 175050 600993
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001666: response to hypoxia
GO:0001701: in utero embryonic development
GO:0001702: gastrulation with mouth forming second
GO:0003190: atrioventricular valve formation
GO:0003198: epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003251: positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0003279: cardiac septum development
GO:0003360: brainstem development
GO:0006351: transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007183: SMAD protein complex assembly
GO:0007411: axon guidance
GO:0007492: endoderm development
GO:0007498: mesoderm development
GO:0008283: cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0010467: gene expression
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014033: neural crest cell differentiation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0017015: regulation of transforming growth factor beta receptor signaling pathway
GO:0030308: negative regulation of cell growth
GO:0030509: BMP signaling pathway
GO:0030511: positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030513: positive regulation of BMP signaling pathway
GO:0032525: somite rostral/caudal axis specification
GO:0032909: regulation of transforming growth factor beta2 production
GO:0036302: atrioventricular canal development
GO:0042118: endothelial cell activation
GO:0042177: negative regulation of protein catabolic process
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048589: developmental growth
GO:0048663: neuron fate commitment
GO:0048733: sebaceous gland development
GO:0048859: formation of anatomical boundary
GO:0051098: regulation of binding
GO:0051797: regulation of hair follicle development
GO:0060021: palate development
GO:0060391: positive regulation of SMAD protein import into nucleus
GO:0060395: SMAD protein signal transduction
GO:0060548: negative regulation of cell death
GO:0060956: endocardial cell differentiation
GO:0071559: response to transforming growth factor beta stimulus
GO:0072133: metanephric mesenchyme morphogenesis
GO:0072134: nephrogenic mesenchyme morphogenesis
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005813: centrosome
GO:0032444: activin responsive factor complex
GO:0071141: SMAD protein complex
GO:0005515: protein binding
GO:0000987: core promoter proximal region sequence-specific DNA binding
GO:0000988: protein binding transcription factor activity
GO:0001076: RNA polymerase II transcription factor binding transcription factor activity
GO:0001085: RNA polymerase II transcription factor binding
GO:0003677: DNA binding
GO:0003682: chromatin binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0030616: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
GO:0046872: metal ion binding
GO:0005518: collagen binding
GO:0042802: identical protein binding
GO:0044212: transcription regulatory region DNA binding
GO:0042803: protein homodimerization activity
GO:0043565: sequence-specific DNA binding
GO:0070411: I-SMAD binding
GO:0070412: R-SMAD binding
KEGG pathways 4110: Cell cycle
4310: Wnt signaling pathway
4350: TGF-beta signaling pathway
4520: Adherens junction
5200: Pathways in cancer
5210: Colorectal cancer
5212: Pancreatic cancer
5220: Chronic myeloid leukemia

PubMed abstracts associated with SMAD4

PMID Title Tumor Value
15174116 Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. no no
20350217 Expression of Smad and its signalling cascade in osteosarcoma. yes no
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