Results for SMAD7

General Information

Gene ID 4092
Gene Symbol SMAD7
Gene Name SMAD family member 7
Gene Type protein-coding
Cytoband 18q21.1
Ensembl ID ENSG00000101665
#miR regulators 22
Omim ID 602932 612229
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001657: ureteric bud development
GO:0035556: intracellular signal transduction
GO:0006351: transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0010467: gene expression
GO:0010719: negative regulation of epithelial to mesenchymal transition
GO:0010801: negative regulation of peptidyl-threonine phosphorylation
GO:0010944: negative regulation of transcription by competitive promoter binding
GO:0017015: regulation of transforming growth factor beta receptor signaling pathway
GO:0050821: protein stabilization
GO:0022409: positive regulation of cell-cell adhesion
GO:0030336: negative regulation of cell migration
GO:0030509: BMP signaling pathway
GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514: negative regulation of BMP signaling pathway
GO:0031397: negative regulation of protein ubiquitination
GO:0031398: positive regulation of protein ubiquitination
GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925: regulation of activin receptor signaling pathway
GO:0033137: negative regulation of peptidyl-serine phosphorylation
GO:0034333: adherens junction assembly
GO:0034616: response to laminar fluid shear stress
GO:0034629: cellular protein complex localization
GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048844: artery morphogenesis
GO:0051444: negative regulation of ubiquitin-protein ligase activity
GO:0055010: ventricular cardiac muscle tissue morphogenesis
GO:0055117: regulation of cardiac muscle contraction
GO:0060373: regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389: pathway-restricted SMAD protein phosphorylation
GO:0060394: negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412: ventricular septum morphogenesis
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005913: cell-cell adherens junction
GO:0016342: catenin complex
GO:0005515: protein binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0030617: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0046872: metal ion binding
GO:0005518: collagen binding
GO:0008013: beta-catenin binding
GO:0044212: transcription regulatory region DNA binding
GO:0031625: ubiquitin protein ligase binding
GO:0034713: type I transforming growth factor beta receptor binding
GO:0048185: activin binding
GO:0070411: I-SMAD binding
KEGG pathways 4144: Endocytosis
4350: TGF-beta signaling pathway

PubMed abstracts associated with SMAD7

PMID Title Tumor Value
16259979 Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. no no
title all all