Results for MCL1

General Information

Gene ID 4170
Gene Symbol MCL1
Gene Name myeloid cell leukemia sequence 1 (BCL2-related)
Gene Type protein-coding
Cytoband 1q21
Ensembl ID ENSG00000143384
#miR regulators 13
Omim ID 159552
Gene ontology GO:0001709: cell fate determination
GO:0006915: apoptotic process
GO:0007275: multicellular organismal development
GO:0019725: cellular homeostasis
GO:0034097: response to cytokine stimulus
GO:0097194: execution phase of apoptosis
GO:1900118: negative regulation of execution phase of apoptosis
GO:2000811: negative regulation of anoikis
GO:2001020: regulation of response to DNA damage stimulus
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0016021: integral to membrane
GO:0016020: membrane
GO:0005739: mitochondrion
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005741: mitochondrial outer membrane
GO:0005759: mitochondrial matrix
GO:0097136: Bcl-2 family protein complex
GO:0005515: protein binding
GO:0015266: protein channel activity
GO:0046982: protein heterodimerization activity
GO:0051434: BH3 domain binding
KEGG pathways ---

PubMed abstracts associated with MCL1

PMID Title Tumor Value
16982772 Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. no no
17471233 Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. no no
20003259 Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. yes no
20459702 Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. yes no
20580954 Functional and biological analysis of Bcl-xL expression in human osteosarcoma. yes no
20808934 Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. no no
21490307 The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. no no
23113351 The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. no no
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
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