Results for MDM2

General Information

Gene ID 4193
Gene Symbol MDM2
Gene Name MDM2 oncogene, E3 ubiquitin protein ligase
Gene Type protein-coding
Cytoband 12q14.3-q15
Ensembl ID ENSG00000135679
#miR regulators 6
Omim ID 164785 614401
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0042787: protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0016567: protein ubiquitination
GO:0006461: protein complex assembly
GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089: traversing start control point of mitotic cell cycle
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007268: synaptic transmission
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0042493: response to drug
GO:0009743: response to carbohydrate stimulus
GO:0010039: response to iron ion
GO:0010628: positive regulation of gene expression
GO:0010955: negative regulation of protein processing
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0046677: response to antibiotic
GO:0018205: peptidyl-lysine modification
GO:0019048: modulation by virus of host morphology or physiology
GO:0048015: phosphatidylinositol-mediated signaling
GO:0031648: protein destabilization
GO:0032026: response to magnesium ion
GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504: protein localization to nucleus
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042176: regulation of protein catabolic process
GO:0042220: response to cocaine
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043278: response to morphine
GO:0043518: negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087: innate immune response
GO:0045184: establishment of protein localization
GO:0045472: response to ether
GO:0045931: positive regulation of mitotic cell cycle
GO:0046827: positive regulation of protein export from nucleus
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0070301: cellular response to hydrogen peroxide
GO:0071157: negative regulation of cell cycle arrest
GO:0071229: cellular response to acid
GO:0071236: cellular response to antibiotic
GO:0071301: cellular response to vitamin B1
GO:0071312: cellular response to alkaloid
GO:0071375: cellular response to peptide hormone stimulus
GO:0071391: cellular response to estrogen stimulus
GO:0071456: cellular response to hypoxia
GO:0071494: cellular response to UV-C
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005730: nucleolus
GO:0016604: nuclear body
GO:0030666: endocytic vesicle membrane
GO:0043234: protein complex
GO:0045202: synapse
GO:0005515: protein binding
GO:0002039: p53 binding
GO:0004842: ubiquitin-protein ligase activity
GO:0008270: zinc ion binding
GO:0042802: identical protein binding
GO:0019899: enzyme binding
GO:0042975: peroxisome proliferator activated receptor binding
GO:0097110: scaffold protein binding
KEGG pathways 4110: Cell cycle
4115: p53 signaling pathway
4120: Ubiquitin mediated proteolysis
4144: Endocytosis
5200: Pathways in cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia

PubMed abstracts associated with MDM2

PMID Title Tumor Value
7591308 MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. yes yes
7828148 The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. yes no
8064888 MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. yes no
8117620 Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. yes no
8416741 MDM2 gene amplification in metastatic osteosarcoma. yes yes
8781571 Alterations of the p53, Rb and MDM2 genes in osteosarcoma. yes no
9118036 p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. yes yes
9227342 Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours. yes no
9559293 Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. yes no
9619593 Comparative genomic hybridization of low-grade central osteosarcoma. yes no
9685858 Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. yes yes
9793960 Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. yes yes
9820862 Genetic instability in osteoblastic tumors of the skeletal system. yes no
9891539 p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different subtypes of human sarcomas: a ten-year follow-up study. yes no
9917506 Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. yes yes
9935200 CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. yes no
9989829 Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. yes no
10101594 Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. yes no
10571205 A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. no no
10942797 Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. yes yes
10943202 Analysis of 12q13-15 genes in parosteal osteosarcoma. yes no
11115584 Osteosarcoma in blood relatives. yes no
11393276 Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells. no no
11564577 Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. yes no
11793439 Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. yes no
12181274 Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. yes no
12747978 Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. yes no
12917637 Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. yes no
12972634 The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. yes no
14610316 Increased mdm-2 expression in a p53-independent manner blocks UV-induced cell cycle arrest and apoptosis in human osteosarcoma cells. no no
15026814 A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin. no no
15167009 Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. yes yes
15207713 Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. no no
15310147 Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. yes no
16596382 Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. yes no
17568187 Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. no no
17959036 Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. no no
19451596 Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival. yes yes
20015022 Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53. no no
20196171 Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. yes no
20601938 Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. yes yes
21159888 Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. yes no
21336260 MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. yes yes
21619704 A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. yes yes
21993662 Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. no no
22205265 The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. yes no
22301501 MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype. yes yes
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no
22749040 12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma. yes yes
22843172 MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. no no
23225447 Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. yes no
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