General Information
Gene ID | 4193 |
---|---|
Gene Symbol | MDM2 |
Gene Name | MDM2 oncogene, E3 ubiquitin protein ligase |
Gene Type | protein-coding |
Cytoband | 12q14.3-q15 |
Ensembl ID | ENSG00000135679 |
#miR regulators | 6 |
Omim ID | 164785 614401 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0042787: protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0016567: protein ubiquitination GO:0006461: protein complex assembly GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007089: traversing start control point of mitotic cell cycle GO:0007173: epidermal growth factor receptor signaling pathway GO:0007268: synaptic transmission GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0008543: fibroblast growth factor receptor signaling pathway GO:0042493: response to drug GO:0009743: response to carbohydrate stimulus GO:0010039: response to iron ion GO:0010628: positive regulation of gene expression GO:0010955: negative regulation of protein processing GO:0045892: negative regulation of transcription, DNA-dependent GO:0046677: response to antibiotic GO:0018205: peptidyl-lysine modification GO:0019048: modulation by virus of host morphology or physiology GO:0048015: phosphatidylinositol-mediated signaling GO:0031648: protein destabilization GO:0032026: response to magnesium ion GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0034504: protein localization to nucleus GO:0038095: Fc-epsilon receptor signaling pathway GO:0042176: regulation of protein catabolic process GO:0042220: response to cocaine GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043278: response to morphine GO:0043518: negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0045087: innate immune response GO:0045184: establishment of protein localization GO:0045472: response to ether GO:0045931: positive regulation of mitotic cell cycle GO:0046827: positive regulation of protein export from nucleus GO:0048011: neurotrophin TRK receptor signaling pathway GO:0070301: cellular response to hydrogen peroxide GO:0071157: negative regulation of cell cycle arrest GO:0071229: cellular response to acid GO:0071236: cellular response to antibiotic GO:0071301: cellular response to vitamin B1 GO:0071312: cellular response to alkaloid GO:0071375: cellular response to peptide hormone stimulus GO:0071391: cellular response to estrogen stimulus GO:0071456: cellular response to hypoxia GO:0071494: cellular response to UV-C GO:0005886: plasma membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005730: nucleolus GO:0016604: nuclear body GO:0030666: endocytic vesicle membrane GO:0043234: protein complex GO:0045202: synapse GO:0005515: protein binding GO:0002039: p53 binding GO:0004842: ubiquitin-protein ligase activity GO:0008270: zinc ion binding GO:0042802: identical protein binding GO:0019899: enzyme binding GO:0042975: peroxisome proliferator activated receptor binding GO:0097110: scaffold protein binding |
KEGG pathways |
4110: Cell cycle 4115: p53 signaling pathway 4120: Ubiquitin mediated proteolysis 4144: Endocytosis 5200: Pathways in cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia |
PMID | Title | Tumor | Value |
---|---|---|---|
7591308 | MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. | yes | yes |
7828148 | The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. | yes | no |
8064888 | MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. | yes | no |
8117620 | Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. | yes | no |
8416741 | MDM2 gene amplification in metastatic osteosarcoma. | yes | yes |
8781571 | Alterations of the p53, Rb and MDM2 genes in osteosarcoma. | yes | no |
9118036 | p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. | yes | yes |
9227342 | Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours. | yes | no |
9559293 | Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. | yes | no |
9619593 | Comparative genomic hybridization of low-grade central osteosarcoma. | yes | no |
9685858 | Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. | yes | yes |
9793960 | Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. | yes | yes |
9820862 | Genetic instability in osteoblastic tumors of the skeletal system. | yes | no |
9891539 | p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different subtypes of human sarcomas: a ten-year follow-up study. | yes | no |
9917506 | Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. | yes | yes |
9935200 | CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. | yes | no |
9989829 | Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. | yes | no |
10101594 | Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. | yes | no |
10571205 | A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. | no | no |
10942797 | Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. | yes | yes |
10943202 | Analysis of 12q13-15 genes in parosteal osteosarcoma. | yes | no |
11115584 | Osteosarcoma in blood relatives. | yes | no |
11393276 | Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells. | no | no |
11564577 | Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. | yes | no |
11793439 | Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. | yes | no |
12181274 | Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. | yes | no |
12747978 | Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. | yes | no |
12917637 | Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. | yes | no |
12972634 | The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. | yes | no |
14610316 | Increased mdm-2 expression in a p53-independent manner blocks UV-induced cell cycle arrest and apoptosis in human osteosarcoma cells. | no | no |
15026814 | A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin. | no | no |
15167009 | Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. | yes | yes |
15207713 | Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. | no | no |
15310147 | Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. | yes | no |
16596382 | Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. | yes | no |
17568187 | Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. | no | no |
17959036 | Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. | no | no |
19451596 | Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival. | yes | yes |
20015022 | Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53. | no | no |
20196171 | Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. | yes | no |
20601938 | Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. | yes | yes |
21159888 | Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. | yes | no |
21336260 | MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. | yes | yes |
21619704 | A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. | yes | yes |
21993662 | Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. | no | no |
22205265 | The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. | yes | no |
22301501 | MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype. | yes | yes |
22674530 | Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. | no | no |
22749040 | 12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma. | yes | yes |
22843172 | MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. | no | no |
23225447 | Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. | yes | no |
title | all | all |