Results for MAP3K5

General Information

Gene ID 4217
Gene Symbol MAP3K5
Gene Name mitogen-activated protein kinase kinase kinase 5
Gene Type protein-coding
Cytoband 6q22.33
Ensembl ID ENSG00000197442
#miR regulators 17
Omim ID 602448
Gene ontology GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254: JNK cascade
GO:0007257: activation of JUN kinase activity
GO:0008631: intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0019048: modulation by virus of host morphology or physiology
GO:0043065: positive regulation of apoptotic process
GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087: innate immune response
GO:0070301: cellular response to hydrogen peroxide
GO:0097190: apoptotic signaling pathway
GO:0005783: endoplasmic reticulum
GO:0005515: protein binding
GO:0000287: magnesium ion binding
GO:0004672: protein kinase activity
GO:0004709: MAP kinase kinase kinase activity
GO:0005524: ATP binding
GO:0042802: identical protein binding
GO:0008656: cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019901: protein kinase binding
GO:0019903: protein phosphatase binding
GO:0042803: protein homodimerization activity
KEGG pathways 4010: MAPK signaling pathway
4141: Protein processing in endoplasmic reticulum
4722: Neurotrophin signaling pathway
5014: Amyotrophic lateral sclerosis (ALS)

PubMed abstracts associated with MAP3K5

PMID Title Tumor Value
18606492 The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. no no
22068640 Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. no no
22583777 Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. yes no
23219526 Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. no no
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