General Information
Gene ID | 4217 |
---|---|
Gene Symbol | MAP3K5 |
Gene Name | mitogen-activated protein kinase kinase kinase 5 |
Gene Type | protein-coding |
Cytoband | 6q22.33 |
Ensembl ID | ENSG00000197442 |
#miR regulators | 17 |
Omim ID | 602448 |
Gene ontology |
GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007254: JNK cascade GO:0007257: activation of JUN kinase activity GO:0008631: intrinsic apoptotic signaling pathway in response to oxidative stress GO:0019048: modulation by virus of host morphology or physiology GO:0043065: positive regulation of apoptotic process GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045087: innate immune response GO:0070301: cellular response to hydrogen peroxide GO:0097190: apoptotic signaling pathway GO:0005783: endoplasmic reticulum GO:0005515: protein binding GO:0000287: magnesium ion binding GO:0004672: protein kinase activity GO:0004709: MAP kinase kinase kinase activity GO:0005524: ATP binding GO:0042802: identical protein binding GO:0008656: cysteine-type endopeptidase activator activity involved in apoptotic process GO:0019901: protein kinase binding GO:0019903: protein phosphatase binding GO:0042803: protein homodimerization activity |
KEGG pathways |
4010: MAPK signaling pathway 4141: Protein processing in endoplasmic reticulum 4722: Neurotrophin signaling pathway 5014: Amyotrophic lateral sclerosis (ALS) |
PMID | Title | Tumor | Value |
---|---|---|---|
18606492 | The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. | no | no |
22068640 | Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. | no | no |
22583777 | Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. | yes | no |
23219526 | Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. | no | no |
title | all | all |