General Information
Gene ID | 4233 |
---|---|
Gene Symbol | MET |
Gene Name | met proto-oncogene (hepatocyte growth factor receptor) |
Gene Type | protein-coding |
Cytoband | 7q31 |
Ensembl ID | ENSG00000105976 |
#miR regulators | 9 |
Omim ID | 114550 164860 605074 611015 |
Gene ontology |
GO:0000187: activation of MAPK activity GO:0001889: liver development GO:0001890: placenta development GO:0007165: signal transduction GO:0007166: cell surface receptor signaling pathway GO:0007411: axon guidance GO:0007420: brain development GO:0030534: adult behavior GO:0008283: cell proliferation GO:0010828: positive regulation of glucose transport GO:0014812: muscle cell migration GO:0014902: myotube differentiation GO:0042593: glucose homeostasis GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046777: protein autophosphorylation GO:0048754: branching morphogenesis of an epithelial tube GO:0051450: myoblast proliferation GO:0060665: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:1901299: negative regulation of hydrogen peroxide-mediated programmed cell death GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0005576: extracellular region GO:0005887: integral to plasma membrane GO:0009925: basal plasma membrane GO:0005515: protein binding GO:0004713: protein tyrosine kinase activity GO:0005008: hepatocyte growth factor-activated receptor activity GO:0005524: ATP binding GO:0019903: protein phosphatase binding |
KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4144: Endocytosis 4360: Axon guidance 4510: Focal adhesion 4520: Adherens junction 5100: Bacterial invasion of epithelial cells 5120: Epithelial cell signaling in Helicobacter pylori infection 5144: Malaria 5200: Pathways in cancer 5211: Renal cell carcinoma 5218: Melanoma |
PMID | Title | Tumor | Value |
---|---|---|---|
7693339 | Met expression and sarcoma tumorigenicity. | yes | no |
7862451 | The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. | yes | no |
8863670 | Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. | yes | no |
9267827 | Expression of c-met proto-oncogene product (c-MET) in benign and malignant bone tumors. | yes | yes |
9788258 | Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. | yes | no |
10872665 | Comparison of histological changes and changes in nm23 and c-MET expression between primary and metastatic sites in osteosarcoma: a clinicopathologic and immunohistochemical study. | yes | yes |
11169148 | Expression of CD31, Met/hepatocyte growth factor receptor and bone morphogenetic protein in bone metastasis of osteosarcoma. | yes | yes |
12388161 | 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. | no | no |
12709413 | Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma. | no | no |
17318900 | Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. | no | no |
17699771 | Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. | no | yes |
17786187 | Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. | yes | yes |
20978190 | Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. | no | no |
21751203 | Cell surface receptor expression patterns in osteosarcoma. | yes | no |
22457788 | MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. | no | no |
22820099 | Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling. | no | no |
title | all | all |