Results for MET

General Information

Gene ID 4233
Gene Symbol MET
Gene Name met proto-oncogene (hepatocyte growth factor receptor)
Gene Type protein-coding
Cytoband 7q31
Ensembl ID ENSG00000105976
#miR regulators 9
Omim ID 114550 164860 605074 611015
Gene ontology GO:0000187: activation of MAPK activity
GO:0001889: liver development
GO:0001890: placenta development
GO:0007165: signal transduction
GO:0007166: cell surface receptor signaling pathway
GO:0007411: axon guidance
GO:0007420: brain development
GO:0030534: adult behavior
GO:0008283: cell proliferation
GO:0010828: positive regulation of glucose transport
GO:0014812: muscle cell migration
GO:0014902: myotube differentiation
GO:0042593: glucose homeostasis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046777: protein autophosphorylation
GO:0048754: branching morphogenesis of an epithelial tube
GO:0051450: myoblast proliferation
GO:0060665: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:1901299: negative regulation of hydrogen peroxide-mediated programmed cell death
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0009925: basal plasma membrane
GO:0005515: protein binding
GO:0004713: protein tyrosine kinase activity
GO:0005008: hepatocyte growth factor-activated receptor activity
GO:0005524: ATP binding
GO:0019903: protein phosphatase binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4144: Endocytosis
4360: Axon guidance
4510: Focal adhesion
4520: Adherens junction
5100: Bacterial invasion of epithelial cells
5120: Epithelial cell signaling in Helicobacter pylori infection
5144: Malaria
5200: Pathways in cancer
5211: Renal cell carcinoma
5218: Melanoma

PubMed abstracts associated with MET

PMID Title Tumor Value
7693339 Met expression and sarcoma tumorigenicity. yes no
7862451 The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. yes no
8863670 Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. yes no
9267827 Expression of c-met proto-oncogene product (c-MET) in benign and malignant bone tumors. yes yes
9788258 Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. yes no
10872665 Comparison of histological changes and changes in nm23 and c-MET expression between primary and metastatic sites in osteosarcoma: a clinicopathologic and immunohistochemical study. yes yes
11169148 Expression of CD31, Met/hepatocyte growth factor receptor and bone morphogenetic protein in bone metastasis of osteosarcoma. yes yes
12388161 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. no no
12709413 Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma. no no
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no
17699771 Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. no yes
17786187 Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. yes yes
20978190 Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. no no
21751203 Cell surface receptor expression patterns in osteosarcoma. yes no
22457788 MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. no no
22820099 Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling. no no
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