Results for MGMT

General Information

Gene ID 4255
Gene Symbol MGMT
Gene Name O-6-methylguanine-DNA methyltransferase
Gene Type protein-coding
Cytoband 10q26
Ensembl ID ENSG00000170430
#miR regulators ---
Omim ID 156569
Gene ontology GO:0006266: DNA ligation
GO:0006281: DNA repair
GO:0006306: DNA methylation
GO:0006307: DNA dealkylation involved in DNA repair
GO:0042493: response to drug
GO:0009636: response to toxic substance
GO:0034599: cellular response to oxidative stress
GO:0043281: regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045471: response to ethanol
GO:0045739: positive regulation of DNA repair
GO:0051593: response to folic acid
GO:0060548: negative regulation of cell death
GO:0060644: mammary gland epithelial cell differentiation
GO:0071407: cellular response to organic cyclic compound
GO:0071479: cellular response to ionizing radiation
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005509: calcium ion binding
GO:0003677: DNA binding
GO:0003908: methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0008168: methyltransferase activity
GO:0009008: DNA-methyltransferase activity
KEGG pathways ---

PubMed abstracts associated with MGMT

PMID Title Tumor Value
16502411 Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma. yes yes
21424568 Relationship between hypermethylated MGMT gene and osteosarcoma necrosis rate after chemotherapy. yes no
21619552 The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy. yes no
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