General Information
| Gene ID | 4255 |
|---|---|
| Gene Symbol | MGMT |
| Gene Name | O-6-methylguanine-DNA methyltransferase |
| Gene Type | protein-coding |
| Cytoband | 10q26 |
| Ensembl ID | ENSG00000170430 |
| #miR regulators | --- |
| Omim ID | 156569 |
| Gene ontology |
GO:0006266: DNA ligation GO:0006281: DNA repair GO:0006306: DNA methylation GO:0006307: DNA dealkylation involved in DNA repair GO:0042493: response to drug GO:0009636: response to toxic substance GO:0034599: cellular response to oxidative stress GO:0043281: regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045471: response to ethanol GO:0045739: positive regulation of DNA repair GO:0051593: response to folic acid GO:0060548: negative regulation of cell death GO:0060644: mammary gland epithelial cell differentiation GO:0071407: cellular response to organic cyclic compound GO:0071479: cellular response to ionizing radiation GO:0005634: nucleus GO:0005654: nucleoplasm GO:0005509: calcium ion binding GO:0003677: DNA binding GO:0003908: methylated-DNA-[protein]-cysteine S-methyltransferase activity GO:0008168: methyltransferase activity GO:0009008: DNA-methyltransferase activity |
| KEGG pathways | --- |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 16502411 | Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma. | yes | yes |
| 21424568 | Relationship between hypermethylated MGMT gene and osteosarcoma necrosis rate after chemotherapy. | yes | no |
| 21619552 | The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy. | yes | no |
| title | all | all |