General Information
| Gene ID | 4277 |
|---|---|
| Gene Symbol | MICB |
| Gene Name | MHC class I polypeptide-related sequence B |
| Gene Type | protein-coding |
| Cytoband | 6p21.3 |
| Ensembl ID | ENSG00000204516 ENSG00000231179 ENSG00000227772 ENSG00000231372 ENSG00000238289 ENSG00000224378 ENSG00000206449 ENSG00000234218 |
| #miR regulators | 12 |
| Omim ID | 602436 |
| Gene ontology |
GO:0002429: immune response-activating cell surface receptor signaling pathway GO:0006955: immune response GO:0006979: response to oxidative stress GO:0019835: cytolysis GO:0009408: response to heat GO:0019048: modulation by virus of host morphology or physiology GO:0019882: antigen processing and presentation GO:0032526: response to retinoic acid GO:0046629: gamma-delta T cell activation GO:0050689: negative regulation of defense response to virus by host GO:0050776: regulation of immune response GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0009986: cell surface GO:0046703: natural killer cell lectin-like receptor binding |
| KEGG pathways |
4650: Natural killer cell mediated cytotoxicity |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 22923031 | Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. | no | no |
| 22992985 | Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner. | no | no |
| title | all | all |