General Information
| Gene ID | 4288 |
|---|---|
| Gene Symbol | MKI67 |
| Gene Name | antigen identified by monoclonal antibody Ki-67 |
| Gene Type | protein-coding |
| Cytoband | 10q26.2 |
| Ensembl ID | ENSG00000148773 |
| #miR regulators | 11 |
| Omim ID | 176741 |
| Gene ontology |
GO:0006259: DNA metabolic process GO:0007126: meiosis GO:0008283: cell proliferation GO:0031100: organ regeneration GO:0034605: cellular response to heat GO:0000793: condensed chromosome GO:0000775: chromosome, centromeric region GO:0005634: nucleus GO:0005737: cytoplasm GO:0005730: nucleolus GO:0005515: protein binding GO:0005524: ATP binding GO:0008022: protein C-terminus binding |
| KEGG pathways | --- |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 8750062 | Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. | yes | no |
| 9538120 | Prognostic significance of cyclin expression in human osteosarcoma. | yes | yes |
| 9685858 | Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. | yes | yes |
| 11155673 | Preliminary observation on the correlation between nm23 expression and Ki-67 antigen with early metastasis of human osteosarcoma. | yes | yes |
| 11341357 | Ki-67: a proliferative marker that may predict pulmonary metastases and mortality of primary osteosarcoma. | yes | yes |
| 12747978 | Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. | yes | no |
| 18941626 | Detection and characterization of CD133+ cancer stem cells in human solid tumours. | no | no |
| 20701666 | Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study. | yes | no |
| 22682017 | Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. | yes | yes |
| 22948234 | Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway. | no | no |
| 23527720 | Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis. | yes | no |
| title | all | all |