General Information
Gene ID | 4313 |
---|---|
Gene Symbol | MMP2 |
Gene Name | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
Gene Type | protein-coding |
Cytoband | 16q13-q21 |
Ensembl ID | ENSG00000087245 |
#miR regulators | 12 |
Omim ID | 120360 259600 |
Gene ontology |
GO:0001525: angiogenesis GO:0001666: response to hypoxia GO:0001955: blood vessel maturation GO:0001957: intramembranous ossification GO:0006508: proteolysis GO:0007566: embryo implantation GO:0022617: extracellular matrix disassembly GO:0071230: cellular response to amino acid stimulus GO:0030198: extracellular matrix organization GO:0030574: collagen catabolic process GO:0044267: cellular protein metabolic process GO:0060325: face morphogenesis GO:0060346: bone trabecula formation GO:0005886: plasma membrane GO:0005739: mitochondrion GO:0005576: extracellular region GO:0005578: proteinaceous extracellular matrix GO:0005615: extracellular space GO:0005634: nucleus GO:0030017: sarcomere GO:0005515: protein binding GO:0004252: serine-type endopeptidase activity GO:0004222: metalloendopeptidase activity GO:0008270: zinc ion binding |
KEGG pathways |
4670: Leukocyte transendothelial migration 4912: GnRH signaling pathway 5200: Pathways in cancer 5219: Bladder cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
9858899 | Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. | no | no |
10493528 | S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. | no | no |
12842447 | Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. | no | no |
14637192 | Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. | no | no |
14713104 | S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. | no | no |
14975209 | Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells. | no | no |
15049011 | Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines. | no | no |
15370596 | Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. | yes | no |
16083752 | Matrix metalloproteinases participate in osteosarcoma invasion. | no | no |
16327977 | Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. | yes | yes |
16417466 | Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. | no | no |
17116726 | Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. | no | no |
17262820 | RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. | no | no |
17318900 | Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. | no | no |
17934334 | Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. | no | no |
17980359 | Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. | no | no |
18047805 | Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. | no | no |
18252811 | Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. | no | no |
18524773 | FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. | no | no |
18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no |
18758062 | Proteome profiling of U2OS cell line in response to a prenylphenol antibiotic isolated from a phytopathogenic fungus. | no | no |
19624845 | Risedronate inhibits human osteosarcoma cell invasion. | no | no |
19682073 | Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. | no | no |
19747555 | Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells. | no | no |
20003259 | Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. | yes | no |
20855150 | Small interfering RNA-directed knockdown of S100A4 decreases proliferation and invasiveness of osteosarcoma cells. | no | no |
20880700 | Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. | yes | yes |
21113498 | Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. | yes | yes |
21443800 | The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. | no | no |
21481226 | Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. | no | no |
21667022 | The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. | no | no |
21750404 | Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. | yes | yes |
22126901 | Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. | no | no |
22426824 | PKD1 negatively regulates cell invasion, migration and proliferation ability of human osteosarcoma. | yes | yes |
22446894 | Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model. | no | no |
22641358 | Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. | no | no |
22923031 | Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. | no | no |
23461061 | C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. | no | no |
23201449 | Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. | no | no |
23266503 | Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. | no | no |
23527718 | The role and clinical significance of YES-associated protein 1 in human osteosarcoma. | no | yes |
title | all | all |