Results for MMP2

General Information

Gene ID 4313
Gene Symbol MMP2
Gene Name matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Gene Type protein-coding
Cytoband 16q13-q21
Ensembl ID ENSG00000087245
#miR regulators 12
Omim ID 120360 259600
Gene ontology GO:0001525: angiogenesis
GO:0001666: response to hypoxia
GO:0001955: blood vessel maturation
GO:0001957: intramembranous ossification
GO:0006508: proteolysis
GO:0007566: embryo implantation
GO:0022617: extracellular matrix disassembly
GO:0071230: cellular response to amino acid stimulus
GO:0030198: extracellular matrix organization
GO:0030574: collagen catabolic process
GO:0044267: cellular protein metabolic process
GO:0060325: face morphogenesis
GO:0060346: bone trabecula formation
GO:0005886: plasma membrane
GO:0005739: mitochondrion
GO:0005576: extracellular region
GO:0005578: proteinaceous extracellular matrix
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0030017: sarcomere
GO:0005515: protein binding
GO:0004252: serine-type endopeptidase activity
GO:0004222: metalloendopeptidase activity
GO:0008270: zinc ion binding
KEGG pathways 4670: Leukocyte transendothelial migration
4912: GnRH signaling pathway
5200: Pathways in cancer
5219: Bladder cancer

PubMed abstracts associated with MMP2

PMID Title Tumor Value
9858899 Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. no no
10493528 S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. no no
12842447 Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. no no
14637192 Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. no no
14713104 S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. no no
14975209 Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells. no no
15049011 Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines. no no
15370596 Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. yes no
16083752 Matrix metalloproteinases participate in osteosarcoma invasion. no no
16327977 Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. yes yes
16417466 Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. no no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
17262820 RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. no no
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no
17934334 Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. no no
17980359 Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. no no
18047805 Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. no no
18252811 Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. no no
18524773 FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. no no
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
18758062 Proteome profiling of U2OS cell line in response to a prenylphenol antibiotic isolated from a phytopathogenic fungus. no no
19624845 Risedronate inhibits human osteosarcoma cell invasion. no no
19682073 Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. no no
19747555 Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells. no no
20003259 Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. yes no
20855150 Small interfering RNA-directed knockdown of S100A4 decreases proliferation and invasiveness of osteosarcoma cells. no no
20880700 Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. yes yes
21113498 Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. yes yes
21443800 The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. no no
21481226 Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. no no
21667022 The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. no no
21750404 Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. yes yes
22126901 Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. no no
22426824 PKD1 negatively regulates cell invasion, migration and proliferation ability of human osteosarcoma. yes yes
22446894 Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model. no no
22641358 Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. no no
22923031 Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. no no
23461061 C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. no no
23201449 Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. no no
23266503 Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. no no
23527718 The role and clinical significance of YES-associated protein 1 in human osteosarcoma. no yes
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