Results for MMP9

General Information

Gene ID 4318
Gene Symbol MMP9
Gene Name matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Gene Type protein-coding
Cytoband 20q11.2-q13.1
Ensembl ID ENSG00000100985
#miR regulators 3
Omim ID 120361 613073
Gene ontology GO:0001501: skeletal system development
GO:0006508: proteolysis
GO:0007566: embryo implantation
GO:0022617: extracellular matrix disassembly
GO:0030198: extracellular matrix organization
GO:0030225: macrophage differentiation
GO:0030574: collagen catabolic process
GO:0043065: positive regulation of apoptotic process
GO:0051549: positive regulation of keratinocyte migration
GO:0005576: extracellular region
GO:0005578: proteinaceous extracellular matrix
GO:0005615: extracellular space
GO:0005515: protein binding
GO:0004222: metalloendopeptidase activity
GO:0005518: collagen binding
GO:0008270: zinc ion binding
KEGG pathways 4670: Leukocyte transendothelial migration
5200: Pathways in cancer
5219: Bladder cancer

PubMed abstracts associated with MMP9

PMID Title Tumor Value
8032535 Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line. no no
9717810 Expression of functional CD40 on human osteosarcoma and Ewing's sarcoma cells. no no
9835898 Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma. yes no
9858899 Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. no no
10390144 Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. no no
10709992 Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. no no
11235987 Antioxidants inhibit TNFalpha-induced motility and invasion of human osteosarcoma cells: possible involvement of NFkappaB activation. no no
12188489 Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells. yes yes
14975209 Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells. no no
15370596 Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. yes no
15701832 Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. no no
16083752 Matrix metalloproteinases participate in osteosarcoma invasion. no no
16417466 Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. no no
17262820 RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. no no
17934334 Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. no no
18047805 Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. no no
18048360 Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. no no
18524773 FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. no no
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
19020756 Increased osteoclast activity is associated with aggressiveness of osteosarcoma. yes no
19624845 Risedronate inhibits human osteosarcoma cell invasion. no no
19730790 Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. no no
20592496 Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. no no
21113498 Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. yes yes
21667022 The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. no no
22126901 Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. no no
22213073 ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9. yes no
22292654 Knockdown of S100A4 decreases tumorigenesis and metastasis in osteosarcoma cells by repression of matrix metalloproteinase-9. yes yes
22333159 High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China. yes yes
22886393 TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. yes no
22923031 Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. no no
23108792 SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. no no
23175213 Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. no no
23322324 Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior. no no
23461061 C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. no no
23192273 IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. yes no
23266503 Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. no no
23527718 The role and clinical significance of YES-associated protein 1 in human osteosarcoma. no yes
23661525 RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9. no no
23684620 Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients. yes yes
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