General Information
Gene ID | 4318 |
---|---|
Gene Symbol | MMP9 |
Gene Name | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
Gene Type | protein-coding |
Cytoband | 20q11.2-q13.1 |
Ensembl ID | ENSG00000100985 |
#miR regulators | 3 |
Omim ID | 120361 613073 |
Gene ontology |
GO:0001501: skeletal system development GO:0006508: proteolysis GO:0007566: embryo implantation GO:0022617: extracellular matrix disassembly GO:0030198: extracellular matrix organization GO:0030225: macrophage differentiation GO:0030574: collagen catabolic process GO:0043065: positive regulation of apoptotic process GO:0051549: positive regulation of keratinocyte migration GO:0005576: extracellular region GO:0005578: proteinaceous extracellular matrix GO:0005615: extracellular space GO:0005515: protein binding GO:0004222: metalloendopeptidase activity GO:0005518: collagen binding GO:0008270: zinc ion binding |
KEGG pathways |
4670: Leukocyte transendothelial migration 5200: Pathways in cancer 5219: Bladder cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
8032535 | Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line. | no | no |
9717810 | Expression of functional CD40 on human osteosarcoma and Ewing's sarcoma cells. | no | no |
9835898 | Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma. | yes | no |
9858899 | Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. | no | no |
10390144 | Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. | no | no |
10709992 | Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. | no | no |
11235987 | Antioxidants inhibit TNFalpha-induced motility and invasion of human osteosarcoma cells: possible involvement of NFkappaB activation. | no | no |
12188489 | Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells. | yes | yes |
14975209 | Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells. | no | no |
15370596 | Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. | yes | no |
15701832 | Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. | no | no |
16083752 | Matrix metalloproteinases participate in osteosarcoma invasion. | no | no |
16417466 | Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. | no | no |
17262820 | RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. | no | no |
17934334 | Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. | no | no |
18047805 | Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. | no | no |
18048360 | Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. | no | no |
18524773 | FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. | no | no |
18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no |
19020756 | Increased osteoclast activity is associated with aggressiveness of osteosarcoma. | yes | no |
19624845 | Risedronate inhibits human osteosarcoma cell invasion. | no | no |
19730790 | Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. | no | no |
20592496 | Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. | no | no |
21113498 | Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. | yes | yes |
21667022 | The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. | no | no |
22126901 | Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. | no | no |
22213073 | ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9. | yes | no |
22292654 | Knockdown of S100A4 decreases tumorigenesis and metastasis in osteosarcoma cells by repression of matrix metalloproteinase-9. | yes | yes |
22333159 | High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China. | yes | yes |
22886393 | TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. | yes | no |
22923031 | Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. | no | no |
23108792 | SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. | no | no |
23175213 | Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. | no | no |
23322324 | Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior. | no | no |
23461061 | C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. | no | no |
23192273 | IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. | yes | no |
23266503 | Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. | no | no |
23527718 | The role and clinical significance of YES-associated protein 1 in human osteosarcoma. | no | yes |
23661525 | RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9. | no | no |
23684620 | Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients. | yes | yes |
title | all | all |