Results for MMP14

General Information

Gene ID 4323
Gene Symbol MMP14
Gene Name matrix metallopeptidase 14 (membrane-inserted)
Gene Type protein-coding
Cytoband 14q11-q12
Ensembl ID ENSG00000157227
#miR regulators 8
Omim ID 600754
Gene ontology GO:0001503: ossification
GO:0001525: angiogenesis
GO:0001541: ovarian follicle development
GO:0001666: response to hypoxia
GO:0001935: endothelial cell proliferation
GO:0006508: proteolysis
GO:0009612: response to mechanical stimulus
GO:0006979: response to oxidative stress
GO:0022617: extracellular matrix disassembly
GO:0030198: extracellular matrix organization
GO:0030307: positive regulation of cell growth
GO:0030324: lung development
GO:0030335: positive regulation of cell migration
GO:0030574: collagen catabolic process
GO:0031638: zymogen activation
GO:0043615: astrocyte cell migration
GO:0043627: response to estrogen stimulus
GO:0048754: branching morphogenesis of an epithelial tube
GO:0048771: tissue remodeling
GO:0051895: negative regulation of focal adhesion assembly
GO:0005886: plasma membrane
GO:0005887: integral to plasma membrane
GO:0005737: cytoplasm
GO:0005796: Golgi lumen
GO:0031012: extracellular matrix
GO:0042470: melanosome
GO:0005515: protein binding
GO:0005509: calcium ion binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0004222: metalloendopeptidase activity
GO:0005178: integrin binding
GO:0008270: zinc ion binding
GO:0016504: peptidase activator activity
KEGG pathways 4912: GnRH signaling pathway

PubMed abstracts associated with MMP14

PMID Title Tumor Value
10493528 S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. no no
12842447 Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. no no
14637192 Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. no no
14713104 S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. no no
16327977 Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. yes yes
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
19682073 Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. no no
21517265 SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. no no
21671177 Influence of ?-catenin small interfering RNA on human osteosarcoma cells. no no
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