General Information
Gene ID | 4323 |
---|---|
Gene Symbol | MMP14 |
Gene Name | matrix metallopeptidase 14 (membrane-inserted) |
Gene Type | protein-coding |
Cytoband | 14q11-q12 |
Ensembl ID | ENSG00000157227 |
#miR regulators | 8 |
Omim ID | 600754 |
Gene ontology |
GO:0001503: ossification GO:0001525: angiogenesis GO:0001541: ovarian follicle development GO:0001666: response to hypoxia GO:0001935: endothelial cell proliferation GO:0006508: proteolysis GO:0009612: response to mechanical stimulus GO:0006979: response to oxidative stress GO:0022617: extracellular matrix disassembly GO:0030198: extracellular matrix organization GO:0030307: positive regulation of cell growth GO:0030324: lung development GO:0030335: positive regulation of cell migration GO:0030574: collagen catabolic process GO:0031638: zymogen activation GO:0043615: astrocyte cell migration GO:0043627: response to estrogen stimulus GO:0048754: branching morphogenesis of an epithelial tube GO:0048771: tissue remodeling GO:0051895: negative regulation of focal adhesion assembly GO:0005886: plasma membrane GO:0005887: integral to plasma membrane GO:0005737: cytoplasm GO:0005796: Golgi lumen GO:0031012: extracellular matrix GO:0042470: melanosome GO:0005515: protein binding GO:0005509: calcium ion binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0004222: metalloendopeptidase activity GO:0005178: integrin binding GO:0008270: zinc ion binding GO:0016504: peptidase activator activity |
KEGG pathways |
4912: GnRH signaling pathway |
PMID | Title | Tumor | Value |
---|---|---|---|
10493528 | S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. | no | no |
12842447 | Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. | no | no |
14637192 | Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. | no | no |
14713104 | S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. | no | no |
16327977 | Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. | yes | yes |
17318900 | Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. | no | no |
18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no |
19682073 | Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. | no | no |
21517265 | SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. | no | no |
21671177 | Influence of β-catenin small interfering RNA on human osteosarcoma cells. | no | no |
title | all | all |