General Information
| Gene ID | 4522 |
|---|---|
| Gene Symbol | MTHFD1 |
| Gene Name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
| Gene Type | protein-coding |
| Cytoband | 14q24 |
| Ensembl ID | ENSG00000100714 |
| #miR regulators | 1 |
| Omim ID | 172460 601634 |
| Gene ontology |
GO:0000105: histidine biosynthetic process GO:0006164: purine nucleotide biosynthetic process GO:0006730: one-carbon metabolic process GO:0006766: vitamin metabolic process GO:0006767: water-soluble vitamin metabolic process GO:0009086: methionine biosynthetic process GO:0009396: folic acid-containing compound biosynthetic process GO:0035999: tetrahydrofolate interconversion GO:0044281: small molecule metabolic process GO:0046655: folic acid metabolic process GO:0005739: mitochondrion GO:0005829: cytosol GO:0005737: cytoplasm GO:0004329: formate-tetrahydrofolate ligase activity GO:0004477: methenyltetrahydrofolate cyclohydrolase activity GO:0004486: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity GO:0004488: methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0005524: ATP binding |
| KEGG pathways |
670: One carbon pool by folate 1100: Metabolic pathways |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 21887680 | Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. | yes | no |
| title | all | all |