Results for MTHFD1

General Information

Gene ID 4522
Gene Symbol MTHFD1
Gene Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
Gene Type protein-coding
Cytoband 14q24
Ensembl ID ENSG00000100714
#miR regulators 1
Omim ID 172460 601634
Gene ontology GO:0000105: histidine biosynthetic process
GO:0006164: purine nucleotide biosynthetic process
GO:0006730: one-carbon metabolic process
GO:0006766: vitamin metabolic process
GO:0006767: water-soluble vitamin metabolic process
GO:0009086: methionine biosynthetic process
GO:0009396: folic acid-containing compound biosynthetic process
GO:0035999: tetrahydrofolate interconversion
GO:0044281: small molecule metabolic process
GO:0046655: folic acid metabolic process
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005737: cytoplasm
GO:0004329: formate-tetrahydrofolate ligase activity
GO:0004477: methenyltetrahydrofolate cyclohydrolase activity
GO:0004486: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0004488: methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524: ATP binding
KEGG pathways 670: One carbon pool by folate
1100: Metabolic pathways

PubMed abstracts associated with MTHFD1

PMID Title Tumor Value
21887680 Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. yes no
title all all