General Information
| Gene ID | 4524 |
|---|---|
| Gene Symbol | MTHFR |
| Gene Name | methylenetetrahydrofolate reductase (NAD(P)H) |
| Gene Type | protein-coding |
| Cytoband | 1p36.3 |
| Ensembl ID | ENSG00000177000 |
| #miR regulators | 9 |
| Omim ID | 181500 188050 236250 601634 607093 |
| Gene ontology |
GO:0006520: cellular amino acid metabolic process GO:0006766: vitamin metabolic process GO:0006767: water-soluble vitamin metabolic process GO:0008015: blood circulation GO:0009086: methionine biosynthetic process GO:0035999: tetrahydrofolate interconversion GO:0044281: small molecule metabolic process GO:0046655: folic acid metabolic process GO:0050667: homocysteine metabolic process GO:0005829: cytosol GO:0004489: methylenetetrahydrofolate reductase (NADPH) activity GO:0072341: modified amino acid binding |
| KEGG pathways |
670: One carbon pool by folate 1100: Metabolic pathways |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 18498722 | Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients. | yes | no |
| 21887680 | Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. | yes | no |
| title | all | all |