Results for MTHFR

General Information

Gene ID 4524
Gene Symbol MTHFR
Gene Name methylenetetrahydrofolate reductase (NAD(P)H)
Gene Type protein-coding
Cytoband 1p36.3
Ensembl ID ENSG00000177000
#miR regulators 9
Omim ID 181500 188050 236250 601634 607093
Gene ontology GO:0006520: cellular amino acid metabolic process
GO:0006766: vitamin metabolic process
GO:0006767: water-soluble vitamin metabolic process
GO:0008015: blood circulation
GO:0009086: methionine biosynthetic process
GO:0035999: tetrahydrofolate interconversion
GO:0044281: small molecule metabolic process
GO:0046655: folic acid metabolic process
GO:0050667: homocysteine metabolic process
GO:0005829: cytosol
GO:0004489: methylenetetrahydrofolate reductase (NADPH) activity
GO:0072341: modified amino acid binding
KEGG pathways 670: One carbon pool by folate
1100: Metabolic pathways

PubMed abstracts associated with MTHFR

PMID Title Tumor Value
18498722 Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients. yes no
21887680 Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. yes no
title all all