Results for MYC

General Information

Gene ID 4609
Gene Symbol MYC
Gene Name v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Type protein-coding
Cytoband 8q24.21
Ensembl ID ENSG00000136997
#miR regulators 2
Omim ID 113970 190080
Gene ontology GO:0051276: chromosome organization
GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000165: MAPK cascade
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001783: B cell apoptotic process
GO:0001836: release of cytochrome c from mitochondria
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002904: positive regulation of B cell apoptotic process
GO:0006006: glucose metabolic process
GO:0006112: energy reserve metabolic process
GO:0006309: apoptotic DNA fragmentation
GO:0006338: chromatin remodeling
GO:0006351: transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0016485: protein processing
GO:0006879: cellular iron ion homeostasis
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974: response to DNA damage stimulus
GO:0007050: cell cycle arrest
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007219: Notch signaling pathway
GO:0007346: regulation of mitotic cell cycle
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0042493: response to drug
GO:0010332: response to gamma radiation
GO:0010467: gene expression
GO:0015671: oxygen transport
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0032091: negative regulation of protein binding
GO:0032204: regulation of telomere maintenance
GO:0032873: negative regulation of stress-activated MAPK cascade
GO:0034644: cellular response to UV
GO:0035690: cellular response to drug
GO:0035914: skeletal muscle cell differentiation
GO:0042474: middle ear morphogenesis
GO:0043279: response to alkaloid
GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043473: pigmentation
GO:0044346: fibroblast apoptotic process
GO:0045656: negative regulation of monocyte differentiation
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048146: positive regulation of fibroblast proliferation
GO:0048147: negative regulation of fibroblast proliferation
GO:0048705: skeletal system morphogenesis
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050910: detection of mechanical stimulus involved in sensory perception of sound
GO:0051782: negative regulation of cell division
GO:0070848: response to growth factor stimulus
GO:0060070: canonical Wnt receptor signaling pathway
GO:0090096: positive regulation of metanephric cap mesenchymal cell proliferation
GO:0097193: intrinsic apoptotic signaling pathway
GO:2000573: positive regulation of DNA biosynthetic process
GO:2001022: positive regulation of response to DNA damage stimulus
GO:2001235: positive regulation of apoptotic signaling pathway
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005730: nucleolus
GO:0005819: spindle
GO:0016604: nuclear body
GO:0030424: axon
GO:0043234: protein complex
GO:0005515: protein binding
GO:0000987: core promoter proximal region sequence-specific DNA binding
GO:0003677: DNA binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0008134: transcription factor binding
GO:0032403: protein complex binding
GO:0046982: protein heterodimerization activity
GO:0070491: repressing transcription factor binding
GO:0070888: E-box binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4110: Cell cycle
4310: Wnt signaling pathway
4350: TGF-beta signaling pathway
4630: Jak-STAT signaling pathway
5200: Pathways in cancer
5210: Colorectal cancer
5213: Endometrial cancer
5216: Thyroid cancer
5219: Bladder cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5222: Small cell lung cancer

PubMed abstracts associated with MYC

PMID Title Tumor Value
1315190 Regulation of C-myc protooncogene expression in osteoblastic cells by arachidonic acid metabolites: relationship to proliferation. no no
1846564 Homologous and heterologous regulation of 1,25-dihydroxyvitamin D-3 receptor mRNA levels in human osteosarcoma cells. no no
2450880 Tumor necrosis factor stimulates proliferation of human osteosarcoma cells and accumulation of c-myc messenger RNA. no no
2496060 Amplification of both c-myc and c-raf-1 oncogenes in a human osteosarcoma. yes no
7576109 Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. no no
7859736 Inhibition of apoptosis by the retinoblastoma gene product. no no
8287230 Sporadic amplification of the MYC gene in human osteosarcomas. yes no
8513277 Alterations of retinoblastoma susceptible gene accompanied by c-myc amplification in human bone and soft tissue tumors. yes yes
8891902 Oncogene alterations in primary, recurrent, and metastatic human bone tumors. yes yes
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
9258335 Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. no no
9778623 C-myc and c-fos in human osteosarcoma: prognostic value of mRNA and protein expression. yes yes
9820862 Genetic instability in osteoblastic tumors of the skeletal system. yes no
10862039 Chromosomal regions involved in the pathogenesis of osteosarcomas. yes yes
11115584 Osteosarcoma in blood relatives. yes no
11746520 Cellular and molecular properties associated with osteosarcoma cells. yes no
14506695 High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. yes no
14582536 Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. no no
14633705 SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
16466985 Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. no no
16596382 Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. yes no
16878156 Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. no no
17569615 IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells. no no
18385200 Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma. yes no
18981708 (18)F and (18)FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation. yes no
19105235 Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. no no
19730790 Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. no no
20610556 Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma. yes yes
20926002 Celecoxib inhibits β-catenin-dependent survival of the human osteosarcoma MG-63 cell line. no no
21890444 Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. yes yes
22037351 Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. no no
22212432 Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells. no no
22855059 Expression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcoma. yes yes
22926753 SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells. no no
23137772 A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. yes no
23461061 C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. no no
24009496 How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation no no
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