Results for ATM

General Information

Gene ID 472
Gene Symbol ATM
Gene Name ataxia telangiectasia mutated
Gene Type protein-coding
Cytoband 11q22-q23
Ensembl ID ENSG00000149311
#miR regulators 15
Omim ID 114480 208900 607585
Gene ontology GO:0000723: telomere maintenance
GO:0000724: double-strand break repair via homologous recombination
GO:0001666: response to hypoxia
GO:0001756: somitogenesis
GO:0002331: pre-B cell allelic exclusion
GO:0007165: signal transduction
GO:0006281: DNA repair
GO:0006302: double-strand break repair
GO:0006468: protein phosphorylation
GO:0006974: response to DNA damage stimulus
GO:0006975: DNA damage induced protein phosphorylation
GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050: cell cycle arrest
GO:0007094: mitotic spindle assembly checkpoint
GO:0007131: reciprocal meiotic recombination
GO:0007292: female gamete generation
GO:0007420: brain development
GO:0007507: heart development
GO:0043066: negative regulation of apoptotic process
GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212: response to ionizing radiation
GO:0018105: peptidyl-serine phosphorylation
GO:0030889: negative regulation of B cell proliferation
GO:0031572: G2 DNA damage checkpoint
GO:0036092: phosphatidylinositol-3-phosphate biosynthetic process
GO:0042159: lipoprotein catabolic process
GO:0043065: positive regulation of apoptotic process
GO:0043517: positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525: positive regulation of neuron apoptotic process
GO:0046777: protein autophosphorylation
GO:0051402: neuron apoptotic process
GO:0071044: histone mRNA catabolic process
GO:0071480: cellular response to gamma radiation
GO:0090399: replicative senescence
GO:0000781: chromosome, telomeric region
GO:0005654: nucleoplasm
GO:0005819: spindle
GO:0016023: cytoplasmic membrane-bounded vesicle
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0004674: protein serine/threonine kinase activity
GO:0004677: DNA-dependent protein kinase activity
GO:0005524: ATP binding
GO:0046983: protein dimerization activity
GO:0016303: 1-phosphatidylinositol-3-kinase activity
GO:0032403: protein complex binding
GO:0035174: histone serine kinase activity
GO:0047485: protein N-terminus binding
KEGG pathways 4110: Cell cycle
4115: p53 signaling pathway
4210: Apoptosis

PubMed abstracts associated with ATM

PMID Title Tumor Value
15705874 Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. no no
17611684 Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. no no
title all all