Results for NFKB1

General Information

Gene ID 4790
Gene Symbol NFKB1
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Gene Type protein-coding
Cytoband 4q24
Ensembl ID ENSG00000109320
#miR regulators 7
Omim ID 164011
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001818: negative regulation of cytokine production
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006366: transcription from RNA polymerase II promoter
GO:0006915: apoptotic process
GO:0006954: inflammatory response
GO:0006979: response to oxidative stress
GO:0043066: negative regulation of apoptotic process
GO:0009617: response to bacterium
GO:0010744: positive regulation of macrophage derived foam cell differentiation
GO:0010884: positive regulation of lipid storage
GO:0010956: negative regulation of calcidiol 1-monooxygenase activity
GO:0010957: negative regulation of vitamin D biosynthetic process
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0050852: T cell receptor signaling pathway
GO:0071260: cellular response to mechanical stimulus
GO:0031293: membrane protein intracellular domain proteolysis
GO:0032269: negative regulation of cellular protein metabolic process
GO:0032375: negative regulation of cholesterol transport
GO:0032481: positive regulation of type I interferon production
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0045083: negative regulation of interleukin-12 biosynthetic process
GO:0045087: innate immune response
GO:0046688: response to copper ion
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050728: negative regulation of inflammatory response
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0071347: cellular response to interleukin-1
GO:0090263: positive regulation of canonical Wnt receptor signaling pathway
GO:1900127: positive regulation of hyaluronan biosynthetic process
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0033256: I-kappaB/NF-kappaB complex
GO:0005515: protein binding
GO:0000975: regulatory region DNA binding
GO:0000976: transcription regulatory region sequence-specific DNA binding
GO:0001071: nucleic acid binding transcription factor activity
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0008134: transcription factor binding
GO:0044212: transcription regulatory region DNA binding
GO:0031072: heat shock protein binding
GO:0042803: protein homodimerization activity
KEGG pathways 4010: MAPK signaling pathway
4062: Chemokine signaling pathway
4210: Apoptosis
4380: Osteoclast differentiation
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
4623: Cytosolic DNA-sensing pathway
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4722: Neurotrophin signaling pathway
4920: Adipocytokine signaling pathway
5120: Epithelial cell signaling in Helicobacter pylori infection
5131: Shigellosis
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5146: Amoebiasis
5160: Hepatitis C
5200: Pathways in cancer
5212: Pancreatic cancer
5215: Prostate cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5222: Small cell lung cancer

PubMed abstracts associated with NFKB1

PMID Title Tumor Value
11235987 Antioxidants inhibit TNFalpha-induced motility and invasion of human osteosarcoma cells: possible involvement of NFkappaB activation. no no
11820362 Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells. no no
12012007 The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells. no no
12237108 Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. no no
14637192 Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. no no
15318945 Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4. no no
15625311 Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2alpha pathway in human osteoblastic MG63 cells. no no
15735172 An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma. yes yes
16167336 Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. no no
16259979 Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. no no
16417466 Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. no no
16795036 Okadaic acid induces phosphorylation of p65NF-kappaB on serine 536 and activates NF-kappaB transcriptional activity in human osteoblastic MG63 cells. no no
16797629 Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. no no
17611696 Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. no no
18598236 Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells. no no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
19496172 Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. no no
20038829 Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-kappaB. no no
20368414 IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth. no no
20798956 TIMP-1 interaction with ?v?3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-?-induced apoptosis. no no
21234653 Anti-tumor effects of dihydroartemisinin on human osteosarcoma. no no
21517265 SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. no no
21527497 Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. no no
21964477 Okadaic acid induces apoptosis through the PKR, NF-?B and caspase pathway in human osteoblastic osteosarcoma MG63 cells. no no
22263786 Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-?B pathway. no no
22382389 Inhibition of nuclear factor-?B by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells. no no
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
22534782 Glycogen synthase kinase-3?, NF-?B signaling, and tumorigenesis of human osteosarcoma. no no
22688575 Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. no no
22993301 Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-?B and MAPK pathways. no no
23091618 Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. no no
23164673 The glycogen synthase kinase-3?/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. no no
24009496 How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation no no
23232982 Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-?B pathway. no no
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