General Information
Gene ID | 4843 |
---|---|
Gene Symbol | NOS2 |
Gene Name | nitric oxide synthase 2, inducible |
Gene Type | protein-coding |
Cytoband | 17q11.2-q12 |
Ensembl ID | ENSG00000007171 |
#miR regulators | 7 |
Omim ID | 145500 163730 611162 |
Gene ontology |
GO:0001666: response to hypoxia GO:0001912: positive regulation of leukocyte mediated cytotoxicity GO:0002227: innate immune response in mucosa GO:0042742: defense response to bacterium GO:0007596: blood coagulation GO:0006527: arginine catabolic process GO:0006801: superoxide metabolic process GO:0006809: nitric oxide biosynthetic process GO:0006954: inflammatory response GO:0007263: nitric oxide mediated signal transduction GO:0050796: regulation of insulin secretion GO:0050829: defense response to Gram-negative bacterium GO:0045909: positive regulation of vasodilation GO:0009617: response to bacterium GO:0010629: negative regulation of gene expression GO:0018119: peptidyl-cysteine S-nitrosylation GO:0031284: positive regulation of guanylate cyclase activity GO:0042127: regulation of cell proliferation GO:0042177: negative regulation of protein catabolic process GO:0043457: regulation of cellular respiration GO:0045776: negative regulation of blood pressure GO:0051701: interaction with host GO:0051712: positive regulation of killing of cells of other organism GO:0071222: cellular response to lipopolysaccharide GO:0071346: cellular response to interferon-gamma GO:0090382: phagosome maturation GO:0005622: intracellular GO:0005829: cytosol GO:0005777: peroxisome GO:0005634: nucleus GO:0005737: cytoplasm GO:0030863: cortical cytoskeleton GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0003958: NADPH-hemoprotein reductase activity GO:0005102: receptor binding GO:0004517: nitric-oxide synthase activity GO:0005506: iron ion binding GO:0005516: calmodulin binding GO:0010181: FMN binding GO:0020037: heme binding GO:0034617: tetrahydrobiopterin binding GO:0034618: arginine binding GO:0042803: protein homodimerization activity GO:0050660: flavin adenine dinucleotide binding GO:0050661: NADP binding |
KEGG pathways |
330: Arginine and proline metabolism 1100: Metabolic pathways 4020: Calcium signaling pathway 4146: Peroxisome 5140: Leishmaniasis 5142: Chagas disease (American trypanosomiasis) 5145: Toxoplasmosis 5146: Amoebiasis 5200: Pathways in cancer 5222: Small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
17391929 | Expression and pathological relevance of inducible nitric oxide synthase in osteosarcoma of the jaws. | yes | yes |
title | all | all |