Results for NOTCH1

General Information

Gene ID 4851
Gene Symbol NOTCH1
Gene Name notch 1
Gene Type protein-coding
Cytoband 9q34.3
Ensembl ID ENSG00000148400
#miR regulators 8
Omim ID 109730 190198
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001701: in utero embryonic development
GO:0001708: cell fate specification
GO:0001837: epithelial to mesenchymal transition
GO:0001889: liver development
GO:0001947: heart looping
GO:0002040: sprouting angiogenesis
GO:0002437: inflammatory response to antigenic stimulus
GO:0003157: endocardium development
GO:0003160: endocardium morphogenesis
GO:0003162: atrioventricular node development
GO:0003169: coronary vein morphogenesis
GO:0003180: aortic valve morphogenesis
GO:0003181: atrioventricular valve morphogenesis
GO:0003184: pulmonary valve morphogenesis
GO:0003192: mitral valve formation
GO:0003198: epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203: endocardial cushion morphogenesis
GO:0003207: cardiac chamber formation
GO:0003208: cardiac ventricle morphogenesis
GO:0003209: cardiac atrium morphogenesis
GO:0003213: cardiac right atrium morphogenesis
GO:0003214: cardiac left ventricle morphogenesis
GO:0003219: cardiac right ventricle formation
GO:0003222: ventricular trabecula myocardium morphogenesis
GO:0003241: growth involved in heart morphogenesis
GO:0003256: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003270: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003273: cell migration involved in endocardial cushion formation
GO:0003344: pericardium morphogenesis
GO:0006355: regulation of transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0006955: immune response
GO:0006959: humoral immune response
GO:0007219: Notch signaling pathway
GO:0007220: Notch receptor processing
GO:0007221: positive regulation of transcription of Notch receptor target
GO:0007368: determination of left/right symmetry
GO:0007386: compartment pattern specification
GO:0007409: axonogenesis
GO:0007440: foregut morphogenesis
GO:0007492: endoderm development
GO:0007507: heart development
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0009912: auditory receptor cell fate commitment
GO:0010001: glial cell differentiation
GO:0010467: gene expression
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0010812: negative regulation of cell-substrate adhesion
GO:0010832: negative regulation of myotube differentiation
GO:0014031: mesenchymal cell development
GO:0014807: regulation of somitogenesis
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0021915: neural tube development
GO:0030216: keratinocyte differentiation
GO:0030279: negative regulation of ossification
GO:0030324: lung development
GO:0030335: positive regulation of cell migration
GO:0030513: positive regulation of BMP signaling pathway
GO:0030514: negative regulation of BMP signaling pathway
GO:0030900: forebrain development
GO:0031069: hair follicle morphogenesis
GO:0032495: response to muramyl dipeptide
GO:0035116: embryonic hindlimb morphogenesis
GO:0035148: tube formation
GO:0035914: skeletal muscle cell differentiation
GO:0035924: cellular response to vascular endothelial growth factor stimulus
GO:0042640: anagen
GO:0043065: positive regulation of apoptotic process
GO:0043086: negative regulation of catalytic activity
GO:0045618: positive regulation of keratinocyte differentiation
GO:0045662: negative regulation of myoblast differentiation
GO:0045668: negative regulation of osteoblast differentiation
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0045955: negative regulation of calcium ion-dependent exocytosis
GO:0046427: positive regulation of JAK-STAT cascade
GO:0046533: negative regulation of photoreceptor cell differentiation
GO:0048103: somatic stem cell division
GO:0048711: positive regulation of astrocyte differentiation
GO:0048715: negative regulation of oligodendrocyte differentiation
GO:0048754: branching morphogenesis of an epithelial tube
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050768: negative regulation of neurogenesis
GO:0055008: cardiac muscle tissue morphogenesis
GO:0060038: cardiac muscle cell proliferation
GO:0060045: positive regulation of cardiac muscle cell proliferation
GO:0060253: negative regulation of glial cell proliferation
GO:0060317: cardiac epithelial to mesenchymal transition
GO:0060411: cardiac septum morphogenesis
GO:0060412: ventricular septum morphogenesis
GO:0060528: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060740: prostate gland epithelium morphogenesis
GO:0060768: regulation of epithelial cell proliferation involved in prostate gland development
GO:0060842: arterial endothelial cell differentiation
GO:0060843: venous endothelial cell differentiation
GO:0060948: cardiac vascular smooth muscle cell development
GO:0060956: endocardial cell differentiation
GO:0060979: vasculogenesis involved in coronary vascular morphogenesis
GO:0060982: coronary artery morphogenesis
GO:0061314: Notch signaling involved in heart development
GO:0061384: heart trabecula morphogenesis
GO:0061419: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986: left/right axis specification
GO:0071372: cellular response to follicle-stimulating hormone stimulus
GO:0072017: distal tubule development
GO:0072044: collecting duct development
GO:0072144: glomerular mesangial cell development
GO:0072602: interleukin-4 secretion
GO:0090051: negative regulation of cell migration involved in sprouting angiogenesis
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0097150: neuronal stem cell maintenance
GO:1901201: regulation of extracellular matrix assembly
GO:2000737: negative regulation of stem cell differentiation
GO:2000811: negative regulation of anoikis
GO:2000974: negative regulation of pro-B cell differentiation
GO:2001027: negative regulation of endothelial cell chemotaxis
GO:0005886: plasma membrane
GO:0000139: Golgi membrane
GO:0016021: integral to membrane
GO:0002193: MAML1-RBP-Jkappa- ICN1 complex
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005789: endoplasmic reticulum membrane
GO:0009986: cell surface
GO:0005515: protein binding
GO:0001047: core promoter binding
GO:0001190: RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0005509: calcium ion binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0004857: enzyme inhibitor activity
GO:0004872: receptor activity
GO:0019899: enzyme binding
GO:0031490: chromatin DNA binding
GO:0043565: sequence-specific DNA binding
KEGG pathways 4320: Dorso-ventral axis formation
4330: Notch signaling pathway
5020: Prion diseases

PubMed abstracts associated with NOTCH1

PMID Title Tumor Value
16354601 Immunohistochemical examination of cytological differentiation in osteosarcomas. yes no
18483362 Critical role of notch signaling in osteosarcoma invasion and metastasis. yes yes
19228774 Notch signaling contributes to the pathogenesis of human osteosarcomas. no no
19455146 Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. no no
20208568 Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness. no no
20213410 How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. no yes
22521131 Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling. no no
24009496 How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation no no
23430952 Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling. no no
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