Results for TNFRSF11B

General Information

Gene ID 4982
Gene Symbol TNFRSF11B
Gene Name tumor necrosis factor receptor superfamily, member 11b
Gene Type protein-coding
Cytoband 8q24
Ensembl ID ENSG00000164761
#miR regulators 12
Omim ID 239000 602643
Gene ontology GO:0001501: skeletal system development
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0007584: response to nutrient
GO:0042493: response to drug
GO:0046685: response to arsenic-containing substance
GO:0030198: extracellular matrix organization
GO:0032026: response to magnesium ion
GO:0042489: negative regulation of odontogenesis of dentin-containing tooth
GO:0043627: response to estrogen stimulus
GO:0045779: negative regulation of bone resorption
GO:0005576: extracellular region
GO:0005578: proteinaceous extracellular matrix
GO:0005615: extracellular space
GO:0004872: receptor activity
GO:0005125: cytokine activity
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4380: Osteoclast differentiation

PubMed abstracts associated with TNFRSF11B

PMID Title Tumor Value
9703945 Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells. no no
15313187 Vitamin A differentially regulates RANKL and OPG expression in human osteoblasts. no no
15742288 Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. no no
15753370 An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. yes no
16533764 Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. no no
17120184 Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. no no
17323424 Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. no no
17645699 Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. yes no
17982618 Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells. no no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
20048075 Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. yes no
20082321 2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells. no no
20955951 Markers of bone remodeling in neoplastic and bone-related lesions. yes no
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