Results for SERPINE1

General Information

Gene ID 5054
Gene Symbol SERPINE1
Gene Name serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Gene Type protein-coding
Cytoband 7q22.1
Ensembl ID ENSG00000106366
#miR regulators 21
Omim ID 173360 613329
Gene ontology GO:0001300: chronological cell aging
GO:0001525: angiogenesis
GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0006351: transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0050829: defense response to Gram-negative bacterium
GO:0010467: gene expression
GO:0010469: regulation of receptor activity
GO:0010757: negative regulation of plasminogen activation
GO:0010951: negative regulation of endopeptidase activity
GO:0014912: negative regulation of smooth muscle cell migration
GO:0030168: platelet activation
GO:0030194: positive regulation of blood coagulation
GO:0030195: negative regulation of blood coagulation
GO:0030198: extracellular matrix organization
GO:0030336: negative regulation of cell migration
GO:0032757: positive regulation of interleukin-8 production
GO:0033629: negative regulation of cell adhesion mediated by integrin
GO:0035491: positive regulation of leukotriene production involved in inflammatory response
GO:0042127: regulation of cell proliferation
GO:0042730: fibrinolysis
GO:0045766: positive regulation of angiogenesis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048260: positive regulation of receptor-mediated endocytosis
GO:0050729: positive regulation of inflammatory response
GO:0051918: negative regulation of fibrinolysis
GO:0061044: negative regulation of vascular wound healing
GO:0061045: negative regulation of wound healing
GO:0071222: cellular response to lipopolysaccharide
GO:0090026: positive regulation of monocyte chemotaxis
GO:1902042: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098: negative regulation of smooth muscle cell-matrix adhesion
GO:2000352: negative regulation of endothelial cell apoptotic process
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0031012: extracellular matrix
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0002020: protease binding
GO:0005102: receptor binding
GO:0004867: serine-type endopeptidase inhibitor activity
KEGG pathways 4115: p53 signaling pathway
4610: Complement and coagulation cascades
5142: Chagas disease (American trypanosomiasis)

PubMed abstracts associated with SERPINE1

PMID Title Tumor Value
11713566 Plasminogen activators and their inhibitor in bone tumors and tumor-like damages. yes no
18445685 PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. yes no
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