General Information
Gene ID | 5054 |
---|---|
Gene Symbol | SERPINE1 |
Gene Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Gene Type | protein-coding |
Cytoband | 7q22.1 |
Ensembl ID | ENSG00000106366 |
#miR regulators | 21 |
Omim ID | 173360 613329 |
Gene ontology |
GO:0001300: chronological cell aging GO:0001525: angiogenesis GO:0002576: platelet degranulation GO:0007596: blood coagulation GO:0006351: transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0007179: transforming growth factor beta receptor signaling pathway GO:0050829: defense response to Gram-negative bacterium GO:0010467: gene expression GO:0010469: regulation of receptor activity GO:0010757: negative regulation of plasminogen activation GO:0010951: negative regulation of endopeptidase activity GO:0014912: negative regulation of smooth muscle cell migration GO:0030168: platelet activation GO:0030194: positive regulation of blood coagulation GO:0030195: negative regulation of blood coagulation GO:0030198: extracellular matrix organization GO:0030336: negative regulation of cell migration GO:0032757: positive regulation of interleukin-8 production GO:0033629: negative regulation of cell adhesion mediated by integrin GO:0035491: positive regulation of leukotriene production involved in inflammatory response GO:0042127: regulation of cell proliferation GO:0042730: fibrinolysis GO:0045766: positive regulation of angiogenesis GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048260: positive regulation of receptor-mediated endocytosis GO:0050729: positive regulation of inflammatory response GO:0051918: negative regulation of fibrinolysis GO:0061044: negative regulation of vascular wound healing GO:0061045: negative regulation of wound healing GO:0071222: cellular response to lipopolysaccharide GO:0090026: positive regulation of monocyte chemotaxis GO:1902042: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:2000098: negative regulation of smooth muscle cell-matrix adhesion GO:2000352: negative regulation of endothelial cell apoptotic process GO:0005886: plasma membrane GO:0005576: extracellular region GO:0005615: extracellular space GO:0031012: extracellular matrix GO:0031093: platelet alpha granule lumen GO:0005515: protein binding GO:0002020: protease binding GO:0005102: receptor binding GO:0004867: serine-type endopeptidase inhibitor activity |
KEGG pathways |
4115: p53 signaling pathway 4610: Complement and coagulation cascades 5142: Chagas disease (American trypanosomiasis) |
PMID | Title | Tumor | Value |
---|---|---|---|
11713566 | Plasminogen activators and their inhibitor in bone tumors and tumor-like damages. | yes | no |
18445685 | PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. | yes | no |
title | all | all |