Results for LEF1

General Information

Gene ID 51176
Gene Symbol LEF1
Gene Name lymphoid enhancer-binding factor 1
Gene Type protein-coding
Cytoband 4q23-q25
Ensembl ID ENSG00000138795
#miR regulators 4
Omim ID 153245
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001569: patterning of blood vessels
GO:0001649: osteoblast differentiation
GO:0001755: neural crest cell migration
GO:0001756: somitogenesis
GO:0001837: epithelial to mesenchymal transition
GO:0002040: sprouting angiogenesis
GO:0006366: transcription from RNA polymerase II promoter
GO:0016055: Wnt receptor signaling pathway
GO:0007420: brain development
GO:0050909: sensory perception of taste
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0010628: positive regulation of gene expression
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0016202: regulation of striated muscle tissue development
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0021542: dentate gyrus development
GO:0021854: hypothalamus development
GO:0021861: forebrain radial glial cell differentiation
GO:0021873: forebrain neuroblast division
GO:0021879: forebrain neuron differentiation
GO:0021943: formation of radial glial scaffolds
GO:0022008: neurogenesis
GO:0022407: regulation of cell-cell adhesion
GO:0022408: negative regulation of cell-cell adhesion
GO:0022409: positive regulation of cell-cell adhesion
GO:0030223: neutrophil differentiation
GO:0030307: positive regulation of cell growth
GO:0030326: embryonic limb morphogenesis
GO:0030335: positive regulation of cell migration
GO:0030509: BMP signaling pathway
GO:0030854: positive regulation of granulocyte differentiation
GO:0030879: mammary gland development
GO:0032696: negative regulation of interleukin-13 production
GO:0032713: negative regulation of interleukin-4 production
GO:0032714: negative regulation of interleukin-5 production
GO:0033153: T cell receptor V(D)J recombination
GO:0042100: B cell proliferation
GO:0042475: odontogenesis of dentin-containing tooth
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392: negative regulation of DNA binding
GO:0043586: tongue development
GO:0043923: positive regulation by host of viral transcription
GO:0043966: histone H3 acetylation
GO:0043967: histone H4 acetylation
GO:0045063: T-helper 1 cell differentiation
GO:0045843: negative regulation of striated muscle tissue development
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046632: alpha-beta T cell differentiation
GO:0048069: eye pigmentation
GO:0048341: paraxial mesoderm formation
GO:0048699: generation of neurons
GO:0048747: muscle fiber development
GO:0060021: palate development
GO:0060033: anatomical structure regression
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060325: face morphogenesis
GO:0060326: cell chemotaxis
GO:0060561: apoptotic process involved in morphogenesis
GO:0060710: chorio-allantoic fusion
GO:0061153: trachea gland development
GO:0071345: cellular response to cytokine stimulus
GO:0071353: cellular response to interleukin-4
GO:0071864: positive regulation of cell proliferation in bone marrow
GO:0071866: negative regulation of apoptotic process in bone marrow
GO:0071895: odontoblast differentiation
GO:0071899: negative regulation of estrogen receptor binding
GO:0090068: positive regulation of cell cycle process
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005667: transcription factor complex
GO:0032993: protein-DNA complex
GO:0005515: protein binding
GO:0000977: RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677: DNA binding
GO:0003682: chromatin binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0042393: histone binding
GO:0008013: beta-catenin binding
GO:0008134: transcription factor binding
GO:0008301: DNA binding, bending
GO:0044212: transcription regulatory region DNA binding
GO:0030284: estrogen receptor activity
GO:0030331: estrogen receptor binding
GO:0035326: enhancer binding
GO:0043027: cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565: sequence-specific DNA binding
GO:0045295: gamma-catenin binding
GO:0070016: armadillo repeat domain binding
GO:0070742: C2H2 zinc finger domain binding
KEGG pathways 4310: Wnt signaling pathway
4520: Adherens junction
4916: Melanogenesis
5200: Pathways in cancer
5210: Colorectal cancer
5213: Endometrial cancer
5215: Prostate cancer
5216: Thyroid cancer
5217: Basal cell carcinoma
5221: Acute myeloid leukemia
5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)

PubMed abstracts associated with LEF1

PMID Title Tumor Value
23291185 Inhibition of the Wnt-?-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. yes yes
title all all