Results for PDGFA

General Information

Gene ID 5154
Gene Symbol PDGFA
Gene Name platelet-derived growth factor alpha polypeptide
Gene Type protein-coding
Cytoband 7p22
Ensembl ID ENSG00000197461
#miR regulators 5
Omim ID 173430
Gene ontology GO:0001525: angiogenesis
GO:0001666: response to hypoxia
GO:0001775: cell activation
GO:0001942: hair follicle development
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002576: platelet degranulation
GO:0030036: actin cytoskeleton organization
GO:0007596: blood coagulation
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007267: cell-cell signaling
GO:0009790: embryo development
GO:0009887: organ morphogenesis
GO:0008284: positive regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0042493: response to drug
GO:0009611: response to wounding
GO:0010035: response to inorganic substance
GO:0010512: negative regulation of phosphatidylinositol biosynthetic process
GO:0010544: negative regulation of platelet activation
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0014910: regulation of smooth muscle cell migration
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030031: cell projection assembly
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030335: positive regulation of cell migration
GO:0031954: positive regulation of protein autophosphorylation
GO:0032355: response to estradiol stimulus
GO:0032526: response to retinoic acid
GO:0032956: regulation of actin cytoskeleton organization
GO:0035793: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042060: wound healing
GO:0043406: positive regulation of MAP kinase activity
GO:0043410: positive regulation of MAPK cascade
GO:0043588: skin development
GO:0045087: innate immune response
GO:0045740: positive regulation of DNA replication
GO:0048008: platelet-derived growth factor receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048146: positive regulation of fibroblast proliferation
GO:0048286: lung alveolus development
GO:0048839: inner ear development
GO:0050730: regulation of peptidyl-tyrosine phosphorylation
GO:0050919: negative chemotaxis
GO:0051781: positive regulation of cell division
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0060683: regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0000139: Golgi membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005788: endoplasmic reticulum lumen
GO:0005902: microvillus
GO:0009986: cell surface
GO:0031093: platelet alpha granule lumen
GO:0005161: platelet-derived growth factor receptor binding
GO:0005518: collagen binding
GO:0008083: growth factor activity
GO:0042803: protein homodimerization activity
GO:0046982: protein heterodimerization activity
GO:0048407: platelet-derived growth factor binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4510: Focal adhesion
4540: Gap junction
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma

PubMed abstracts associated with PDGFA

PMID Title Tumor Value
1316174 Differential migratory response of U-2 OS osteosarcoma cell to the various forms of platelet-derived growth factor. no no
2156959 Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. no no
2630171 The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. no no
3479235 Events on different chromosomes alter the genes for the two peptides of platelet-derived growth factor in an osteogenic sarcoma. yes no
7794813 Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. no no
10874667 Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. yes no
12527715 Expression of platelet-derived growth factor-AA is associated with tumor progression in osteosarcoma. yes yes
14633705 SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. no no
18338812 Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. yes no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
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