Results for PDGFB

General Information

Gene ID 5155
Gene Symbol PDGFB
Gene Name platelet-derived growth factor beta polypeptide
Gene Type protein-coding
Cytoband 22q13.1
Ensembl ID ENSG00000100311
#miR regulators 3
Omim ID 190040 607174 607907
Gene ontology GO:0006260: DNA replication
GO:0016049: cell growth
GO:0001666: response to hypoxia
GO:0001892: embryonic placenta development
GO:0001938: positive regulation of endothelial cell proliferation
GO:0002548: monocyte chemotaxis
GO:0002576: platelet degranulation
GO:0003104: positive regulation of glomerular filtration
GO:0030036: actin cytoskeleton organization
GO:0007596: blood coagulation
GO:0006468: protein phosphorylation
GO:0072593: reactive oxygen species metabolic process
GO:0006929: substrate-dependent cell migration
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007507: heart development
GO:0008284: positive regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0042493: response to drug
GO:0009611: response to wounding
GO:0010512: negative regulation of phosphatidylinositol biosynthetic process
GO:0010544: negative regulation of platelet activation
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0014911: positive regulation of smooth muscle cell migration
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0018105: peptidyl-serine phosphorylation
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0038001: paracrine signaling
GO:0030031: cell projection assembly
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030335: positive regulation of cell migration
GO:0030336: negative regulation of cell migration
GO:0031954: positive regulation of protein autophosphorylation
GO:0032147: activation of protein kinase activity
GO:0032148: activation of protein kinase B activity
GO:0032355: response to estradiol stimulus
GO:0032868: response to insulin stimulus
GO:0035793: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0043406: positive regulation of MAP kinase activity
GO:0043410: positive regulation of MAPK cascade
GO:0043536: positive regulation of blood vessel endothelial cell migration
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087: innate immune response
GO:0045737: positive regulation of cyclin-dependent protein kinase activity
GO:0045740: positive regulation of DNA replication
GO:0045743: positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045840: positive regulation of mitosis
GO:0048008: platelet-derived growth factor receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048146: positive regulation of fibroblast proliferation
GO:0048514: blood vessel morphogenesis
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918: positive chemotaxis
GO:0050921: positive regulation of chemotaxis
GO:0051781: positive regulation of cell division
GO:0060326: cell chemotaxis
GO:0060445: branching involved in salivary gland morphogenesis
GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis
GO:0061098: positive regulation of protein tyrosine kinase activity
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0071363: cellular response to growth factor stimulus
GO:0071506: cellular response to mycophenolic acid
GO:0072126: positive regulation of glomerular mesangial cell proliferation
GO:0072255: metanephric glomerular mesangial cell development
GO:0072262: metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072264: metanephric glomerular endothelium development
GO:0090280: positive regulation of calcium ion import
GO:1900127: positive regulation of hyaluronan biosynthetic process
GO:2000573: positive regulation of DNA biosynthetic process
GO:2000591: positive regulation of metanephric mesenchymal cell migration
GO:0000139: Golgi membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005737: cytoplasm
GO:0005788: endoplasmic reticulum lumen
GO:0009986: cell surface
GO:0016323: basolateral plasma membrane
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0005161: platelet-derived growth factor receptor binding
GO:0005518: collagen binding
GO:0008083: growth factor activity
GO:0016176: superoxide-generating NADPH oxidase activator activity
GO:0042056: chemoattractant activity
GO:0042803: protein homodimerization activity
GO:0046982: protein heterodimerization activity
GO:0048407: platelet-derived growth factor binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4510: Focal adhesion
4540: Gap junction
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5211: Renal cell carcinoma
5214: Glioma
5215: Prostate cancer
5218: Melanoma

PubMed abstracts associated with PDGFB

PMID Title Tumor Value
1316174 Differential migratory response of U-2 OS osteosarcoma cell to the various forms of platelet-derived growth factor. no no
2156959 Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. no no
2630171 The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. no no
3479235 Events on different chromosomes alter the genes for the two peptides of platelet-derived growth factor in an osteogenic sarcoma. yes no
7794813 Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. no no
8662647 Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors. no no
10874667 Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. yes no
18338812 Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. yes no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
19393247 Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. no no
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