General Information
Gene ID | 5155 |
---|---|
Gene Symbol | PDGFB |
Gene Name | platelet-derived growth factor beta polypeptide |
Gene Type | protein-coding |
Cytoband | 22q13.1 |
Ensembl ID | ENSG00000100311 |
#miR regulators | 3 |
Omim ID | 190040 607174 607907 |
Gene ontology |
GO:0006260: DNA replication GO:0016049: cell growth GO:0001666: response to hypoxia GO:0001892: embryonic placenta development GO:0001938: positive regulation of endothelial cell proliferation GO:0002548: monocyte chemotaxis GO:0002576: platelet degranulation GO:0003104: positive regulation of glomerular filtration GO:0030036: actin cytoskeleton organization GO:0007596: blood coagulation GO:0006468: protein phosphorylation GO:0072593: reactive oxygen species metabolic process GO:0006929: substrate-dependent cell migration GO:0007173: epidermal growth factor receptor signaling pathway GO:0007179: transforming growth factor beta receptor signaling pathway GO:0007507: heart development GO:0008284: positive regulation of cell proliferation GO:0008543: fibroblast growth factor receptor signaling pathway GO:0042493: response to drug GO:0009611: response to wounding GO:0010512: negative regulation of phosphatidylinositol biosynthetic process GO:0010544: negative regulation of platelet activation GO:2000379: positive regulation of reactive oxygen species metabolic process GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0014911: positive regulation of smooth muscle cell migration GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0018105: peptidyl-serine phosphorylation GO:0018108: peptidyl-tyrosine phosphorylation GO:0048015: phosphatidylinositol-mediated signaling GO:0038001: paracrine signaling GO:0030031: cell projection assembly GO:0030168: platelet activation GO:0030198: extracellular matrix organization GO:0030335: positive regulation of cell migration GO:0030336: negative regulation of cell migration GO:0031954: positive regulation of protein autophosphorylation GO:0032147: activation of protein kinase activity GO:0032148: activation of protein kinase B activity GO:0032355: response to estradiol stimulus GO:0032868: response to insulin stimulus GO:0035793: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0038095: Fc-epsilon receptor signaling pathway GO:0043406: positive regulation of MAP kinase activity GO:0043410: positive regulation of MAPK cascade GO:0043536: positive regulation of blood vessel endothelial cell migration GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity GO:0045087: innate immune response GO:0045737: positive regulation of cyclin-dependent protein kinase activity GO:0045740: positive regulation of DNA replication GO:0045743: positive regulation of fibroblast growth factor receptor signaling pathway GO:0045840: positive regulation of mitosis GO:0048008: platelet-derived growth factor receptor signaling pathway GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048146: positive regulation of fibroblast proliferation GO:0048514: blood vessel morphogenesis GO:0048661: positive regulation of smooth muscle cell proliferation GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation GO:0050918: positive chemotaxis GO:0050921: positive regulation of chemotaxis GO:0051781: positive regulation of cell division GO:0060326: cell chemotaxis GO:0060445: branching involved in salivary gland morphogenesis GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis GO:0061098: positive regulation of protein tyrosine kinase activity GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0071363: cellular response to growth factor stimulus GO:0071506: cellular response to mycophenolic acid GO:0072126: positive regulation of glomerular mesangial cell proliferation GO:0072255: metanephric glomerular mesangial cell development GO:0072262: metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072264: metanephric glomerular endothelium development GO:0090280: positive regulation of calcium ion import GO:1900127: positive regulation of hyaluronan biosynthetic process GO:2000573: positive regulation of DNA biosynthetic process GO:2000591: positive regulation of metanephric mesenchymal cell migration GO:0000139: Golgi membrane GO:0005576: extracellular region GO:0005615: extracellular space GO:0005737: cytoplasm GO:0005788: endoplasmic reticulum lumen GO:0009986: cell surface GO:0016323: basolateral plasma membrane GO:0031093: platelet alpha granule lumen GO:0005515: protein binding GO:0005161: platelet-derived growth factor receptor binding GO:0005518: collagen binding GO:0008083: growth factor activity GO:0016176: superoxide-generating NADPH oxidase activator activity GO:0042056: chemoattractant activity GO:0042803: protein homodimerization activity GO:0046982: protein heterodimerization activity GO:0048407: platelet-derived growth factor binding |
KEGG pathways |
4010: MAPK signaling pathway 4060: Cytokine-cytokine receptor interaction 4510: Focal adhesion 4540: Gap junction 4810: Regulation of actin cytoskeleton 5200: Pathways in cancer 5211: Renal cell carcinoma 5214: Glioma 5215: Prostate cancer 5218: Melanoma |
PMID | Title | Tumor | Value |
---|---|---|---|
1316174 | Differential migratory response of U-2 OS osteosarcoma cell to the various forms of platelet-derived growth factor. | no | no |
2156959 | Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. | no | no |
2630171 | The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. | no | no |
3479235 | Events on different chromosomes alter the genes for the two peptides of platelet-derived growth factor in an osteogenic sarcoma. | yes | no |
7794813 | Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. | no | no |
8662647 | Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors. | no | no |
10874667 | Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. | yes | no |
18338812 | Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. | yes | no |
18814141 | Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. | no | no |
19393247 | Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. | no | no |
title | all | all |