Results for PDGFRA

General Information

Gene ID 5156
Gene Symbol PDGFRA
Gene Name platelet-derived growth factor receptor, alpha polypeptide
Gene Type protein-coding
Cytoband 4q12
Ensembl ID ENSG00000134853
#miR regulators 26
Omim ID 173490 606764 607685
Gene ontology GO:0001553: luteinization
GO:0001701: in utero embryonic development
GO:0001775: cell activation
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007204: elevation of cytosolic calcium ion concentration
GO:0008210: estrogen metabolic process
GO:0008284: positive regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010544: negative regulation of platelet activation
GO:0010863: positive regulation of phospholipase C activity
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0019048: modulation by virus of host morphology or physiology
GO:0048015: phosphatidylinositol-mediated signaling
GO:0071230: cellular response to amino acid stimulus
GO:0023019: signal transduction involved in regulation of gene expression
GO:0030198: extracellular matrix organization
GO:0030324: lung development
GO:0030325: adrenal gland development
GO:0030335: positive regulation of cell migration
GO:0030539: male genitalia development
GO:0033327: Leydig cell differentiation
GO:0035790: platelet-derived growth factor receptor-alpha signaling pathway
GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042060: wound healing
GO:0042475: odontogenesis of dentin-containing tooth
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087: innate immune response
GO:0045740: positive regulation of DNA replication
GO:0046777: protein autophosphorylation
GO:0048008: platelet-derived growth factor receptor signaling pathway
GO:0048010: vascular endothelial growth factor receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048146: positive regulation of fibroblast proliferation
GO:0048557: embryonic digestive tract morphogenesis
GO:0048701: embryonic cranial skeleton morphogenesis
GO:0048704: embryonic skeletal system morphogenesis
GO:0050920: regulation of chemotaxis
GO:0055003: cardiac myofibril assembly
GO:0060021: palate development
GO:0060325: face morphogenesis
GO:0060326: cell chemotaxis
GO:0061298: retina vasculature development in camera-type eye
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0070527: platelet aggregation
GO:0072277: metanephric glomerular capillary formation
GO:2000249: regulation of actin cytoskeleton reorganization
GO:2000739: regulation of mesenchymal stem cell differentiation
GO:0005886: plasma membrane
GO:0005887: integral to plasma membrane
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0009897: external side of plasma membrane
GO:0031226: intrinsic to plasma membrane
GO:0005515: protein binding
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0005018: platelet-derived growth factor alpha-receptor activity
GO:0005021: vascular endothelial growth factor-activated receptor activity
GO:0005161: platelet-derived growth factor receptor binding
GO:0005524: ATP binding
GO:0038085: vascular endothelial growth factor binding
GO:0042803: protein homodimerization activity
GO:0048407: platelet-derived growth factor binding
KEGG pathways 4010: MAPK signaling pathway
4020: Calcium signaling pathway
4060: Cytokine-cytokine receptor interaction
4144: Endocytosis
4510: Focal adhesion
4540: Gap junction
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma

PubMed abstracts associated with PDGFRA

PMID Title Tumor Value
2156959 Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. no no
10874667 Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. yes no
17294449 KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? yes no
18338812 Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. yes no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
21080877 Expression of platelet-derived growth factor-alpha receptor in human osteosarcoma is not a predictor of outcome. yes no
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