General Information
Gene ID | 5156 |
---|---|
Gene Symbol | PDGFRA |
Gene Name | platelet-derived growth factor receptor, alpha polypeptide |
Gene Type | protein-coding |
Cytoband | 4q12 |
Ensembl ID | ENSG00000134853 |
#miR regulators | 26 |
Omim ID | 173490 606764 607685 |
Gene ontology |
GO:0001553: luteinization GO:0001701: in utero embryonic development GO:0001775: cell activation GO:0007173: epidermal growth factor receptor signaling pathway GO:0007204: elevation of cytosolic calcium ion concentration GO:0008210: estrogen metabolic process GO:0008284: positive regulation of cell proliferation GO:0008543: fibroblast growth factor receptor signaling pathway GO:0010544: negative regulation of platelet activation GO:0010863: positive regulation of phospholipase C activity GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0018108: peptidyl-tyrosine phosphorylation GO:0019048: modulation by virus of host morphology or physiology GO:0048015: phosphatidylinositol-mediated signaling GO:0071230: cellular response to amino acid stimulus GO:0023019: signal transduction involved in regulation of gene expression GO:0030198: extracellular matrix organization GO:0030324: lung development GO:0030325: adrenal gland development GO:0030335: positive regulation of cell migration GO:0030539: male genitalia development GO:0033327: Leydig cell differentiation GO:0035790: platelet-derived growth factor receptor-alpha signaling pathway GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038095: Fc-epsilon receptor signaling pathway GO:0042060: wound healing GO:0042475: odontogenesis of dentin-containing tooth GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity GO:0045087: innate immune response GO:0045740: positive regulation of DNA replication GO:0046777: protein autophosphorylation GO:0048008: platelet-derived growth factor receptor signaling pathway GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048146: positive regulation of fibroblast proliferation GO:0048557: embryonic digestive tract morphogenesis GO:0048701: embryonic cranial skeleton morphogenesis GO:0048704: embryonic skeletal system morphogenesis GO:0050920: regulation of chemotaxis GO:0055003: cardiac myofibril assembly GO:0060021: palate development GO:0060325: face morphogenesis GO:0060326: cell chemotaxis GO:0061298: retina vasculature development in camera-type eye GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0070527: platelet aggregation GO:0072277: metanephric glomerular capillary formation GO:2000249: regulation of actin cytoskeleton reorganization GO:2000739: regulation of mesenchymal stem cell differentiation GO:0005886: plasma membrane GO:0005887: integral to plasma membrane GO:0005634: nucleus GO:0005737: cytoplasm GO:0009897: external side of plasma membrane GO:0031226: intrinsic to plasma membrane GO:0005515: protein binding GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0005018: platelet-derived growth factor alpha-receptor activity GO:0005021: vascular endothelial growth factor-activated receptor activity GO:0005161: platelet-derived growth factor receptor binding GO:0005524: ATP binding GO:0038085: vascular endothelial growth factor binding GO:0042803: protein homodimerization activity GO:0048407: platelet-derived growth factor binding |
KEGG pathways |
4010: MAPK signaling pathway 4020: Calcium signaling pathway 4060: Cytokine-cytokine receptor interaction 4144: Endocytosis 4510: Focal adhesion 4540: Gap junction 4810: Regulation of actin cytoskeleton 5200: Pathways in cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma |
PMID | Title | Tumor | Value |
---|---|---|---|
2156959 | Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. | no | no |
10874667 | Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. | yes | no |
17294449 | KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? | yes | no |
18338812 | Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. | yes | no |
18814141 | Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. | no | no |
21080877 | Expression of platelet-derived growth factor-alpha receptor in human osteosarcoma is not a predictor of outcome. | yes | no |
title | all | all |