General Information
Gene ID | 5159 |
---|---|
Gene Symbol | PDGFRB |
Gene Name | platelet-derived growth factor receptor, beta polypeptide |
Gene Type | protein-coding |
Cytoband | 5q33.1 |
Ensembl ID | ENSG00000113721 |
#miR regulators | 11 |
Omim ID | 131440 173410 615007 |
Gene ontology |
GO:0001701: in utero embryonic development GO:0001894: tissue homeostasis GO:0007165: signal transduction GO:0006024: glycosaminoglycan biosynthetic process GO:0007173: epidermal growth factor receptor signaling pathway GO:0007179: transforming growth factor beta receptor signaling pathway GO:0007243: intracellular protein kinase cascade GO:0008284: positive regulation of cell proliferation GO:0008543: fibroblast growth factor receptor signaling pathway GO:0009636: response to toxic substance GO:2000379: positive regulation of reactive oxygen species metabolic process GO:0010863: positive regulation of phospholipase C activity GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0014911: positive regulation of smooth muscle cell migration GO:0016477: cell migration GO:0018108: peptidyl-tyrosine phosphorylation GO:0048015: phosphatidylinositol-mediated signaling GO:0030325: adrenal gland development GO:0030335: positive regulation of cell migration GO:0032355: response to estradiol stimulus GO:0032516: positive regulation of phosphoprotein phosphatase activity GO:0032526: response to retinoic acid GO:0032956: regulation of actin cytoskeleton organization GO:0032967: positive regulation of collagen biosynthetic process GO:0034405: response to fluid shear stress GO:0035441: cell migration involved in vasculogenesis GO:0035789: metanephric mesenchymal cell migration GO:0035791: platelet-derived growth factor receptor-beta signaling pathway GO:0035793: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035909: aorta morphogenesis GO:0036120: cellular response to platelet-derived growth factor stimulus GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038095: Fc-epsilon receptor signaling pathway GO:0042060: wound healing GO:0042542: response to hydrogen peroxide GO:0043406: positive regulation of MAP kinase activity GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity GO:0045087: innate immune response GO:0045840: positive regulation of mitosis GO:0046488: phosphatidylinositol metabolic process GO:0046777: protein autophosphorylation GO:0048008: platelet-derived growth factor receptor signaling pathway GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048661: positive regulation of smooth muscle cell proliferation GO:0048705: skeletal system morphogenesis GO:0048745: smooth muscle tissue development GO:0048839: inner ear development GO:0050730: regulation of peptidyl-tyrosine phosphorylation GO:0050921: positive regulation of chemotaxis GO:0055003: cardiac myofibril assembly GO:0055093: response to hyperoxia GO:0060326: cell chemotaxis GO:0060981: cell migration involved in coronary angiogenesis GO:0061298: retina vasculature development in camera-type eye GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0071670: smooth muscle cell chemotaxis GO:0072075: metanephric mesenchyme development GO:0072262: metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072277: metanephric glomerular capillary formation GO:0072278: metanephric comma-shaped body morphogenesis GO:0072284: metanephric S-shaped body morphogenesis GO:0090280: positive regulation of calcium ion import GO:2000573: positive regulation of DNA biosynthetic process GO:0005886: plasma membrane GO:0016020: membrane GO:0005887: integral to plasma membrane GO:0005634: nucleus GO:0005737: cytoplasm GO:0016023: cytoplasmic membrane-bounded vesicle GO:0016324: apical plasma membrane GO:0031226: intrinsic to plasma membrane GO:0043202: lysosomal lumen GO:0005515: protein binding GO:0005102: receptor binding GO:0004713: protein tyrosine kinase activity GO:0004992: platelet activating factor receptor activity GO:0005017: platelet-derived growth factor-activated receptor activity GO:0005019: platelet-derived growth factor beta-receptor activity GO:0005021: vascular endothelial growth factor-activated receptor activity GO:0005161: platelet-derived growth factor receptor binding GO:0005524: ATP binding GO:0038085: vascular endothelial growth factor binding GO:0043548: phosphatidylinositol 3-kinase binding GO:0048407: platelet-derived growth factor binding |
KEGG pathways |
4010: MAPK signaling pathway 4020: Calcium signaling pathway 4060: Cytokine-cytokine receptor interaction 4510: Focal adhesion 4540: Gap junction 4810: Regulation of actin cytoskeleton 5200: Pathways in cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma |
PMID | Title | Tumor | Value |
---|---|---|---|
18338812 | Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. | yes | no |
19393247 | Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. | no | no |
21751203 | Cell surface receptor expression patterns in osteosarcoma. | yes | no |
title | all | all |