Results for PDGFRB

General Information

Gene ID 5159
Gene Symbol PDGFRB
Gene Name platelet-derived growth factor receptor, beta polypeptide
Gene Type protein-coding
Cytoband 5q33.1
Ensembl ID ENSG00000113721
#miR regulators 11
Omim ID 131440 173410 615007
Gene ontology GO:0001701: in utero embryonic development
GO:0001894: tissue homeostasis
GO:0007165: signal transduction
GO:0006024: glycosaminoglycan biosynthetic process
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007243: intracellular protein kinase cascade
GO:0008284: positive regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0009636: response to toxic substance
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:0010863: positive regulation of phospholipase C activity
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0014911: positive regulation of smooth muscle cell migration
GO:0016477: cell migration
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030325: adrenal gland development
GO:0030335: positive regulation of cell migration
GO:0032355: response to estradiol stimulus
GO:0032516: positive regulation of phosphoprotein phosphatase activity
GO:0032526: response to retinoic acid
GO:0032956: regulation of actin cytoskeleton organization
GO:0032967: positive regulation of collagen biosynthetic process
GO:0034405: response to fluid shear stress
GO:0035441: cell migration involved in vasculogenesis
GO:0035789: metanephric mesenchymal cell migration
GO:0035791: platelet-derived growth factor receptor-beta signaling pathway
GO:0035793: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0035909: aorta morphogenesis
GO:0036120: cellular response to platelet-derived growth factor stimulus
GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042060: wound healing
GO:0042542: response to hydrogen peroxide
GO:0043406: positive regulation of MAP kinase activity
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087: innate immune response
GO:0045840: positive regulation of mitosis
GO:0046488: phosphatidylinositol metabolic process
GO:0046777: protein autophosphorylation
GO:0048008: platelet-derived growth factor receptor signaling pathway
GO:0048010: vascular endothelial growth factor receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0048705: skeletal system morphogenesis
GO:0048745: smooth muscle tissue development
GO:0048839: inner ear development
GO:0050730: regulation of peptidyl-tyrosine phosphorylation
GO:0050921: positive regulation of chemotaxis
GO:0055003: cardiac myofibril assembly
GO:0055093: response to hyperoxia
GO:0060326: cell chemotaxis
GO:0060981: cell migration involved in coronary angiogenesis
GO:0061298: retina vasculature development in camera-type eye
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0071670: smooth muscle cell chemotaxis
GO:0072075: metanephric mesenchyme development
GO:0072262: metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072277: metanephric glomerular capillary formation
GO:0072278: metanephric comma-shaped body morphogenesis
GO:0072284: metanephric S-shaped body morphogenesis
GO:0090280: positive regulation of calcium ion import
GO:2000573: positive regulation of DNA biosynthetic process
GO:0005886: plasma membrane
GO:0016020: membrane
GO:0005887: integral to plasma membrane
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0016023: cytoplasmic membrane-bounded vesicle
GO:0016324: apical plasma membrane
GO:0031226: intrinsic to plasma membrane
GO:0043202: lysosomal lumen
GO:0005515: protein binding
GO:0005102: receptor binding
GO:0004713: protein tyrosine kinase activity
GO:0004992: platelet activating factor receptor activity
GO:0005017: platelet-derived growth factor-activated receptor activity
GO:0005019: platelet-derived growth factor beta-receptor activity
GO:0005021: vascular endothelial growth factor-activated receptor activity
GO:0005161: platelet-derived growth factor receptor binding
GO:0005524: ATP binding
GO:0038085: vascular endothelial growth factor binding
GO:0043548: phosphatidylinositol 3-kinase binding
GO:0048407: platelet-derived growth factor binding
KEGG pathways 4010: MAPK signaling pathway
4020: Calcium signaling pathway
4060: Cytokine-cytokine receptor interaction
4510: Focal adhesion
4540: Gap junction
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma

PubMed abstracts associated with PDGFRB

PMID Title Tumor Value
18338812 Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. yes no
19393247 Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. no no
21751203 Cell surface receptor expression patterns in osteosarcoma. yes no
title all all