Results for PDPK1

General Information

Gene ID 5170
Gene Symbol PDPK1
Gene Name 3-phosphoinositide dependent protein kinase-1
Gene Type protein-coding
Cytoband 16p13.3
Ensembl ID ENSG00000140992
#miR regulators 11
Omim ID 605213
Gene ontology GO:0003323: type B pancreatic cell development
GO:0030036: actin cytoskeleton organization
GO:0007596: blood coagulation
GO:0035556: intracellular signal transduction
GO:0006351: transcription, DNA-dependent
GO:0006355: regulation of transcription, DNA-dependent
GO:0006468: protein phosphorylation
GO:0006469: negative regulation of protein kinase activity
GO:0006972: hyperosmotic response
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007268: synaptic transmission
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010594: regulation of endothelial cell migration
GO:0010667: negative regulation of cardiac muscle cell apoptotic process
GO:0018107: peptidyl-threonine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0050852: T cell receptor signaling pathway
GO:0030168: platelet activation
GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295: T cell costimulation
GO:0032148: activation of protein kinase B activity
GO:0032869: cellular response to insulin stimulus
GO:0034122: negative regulation of toll-like receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0043122: regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043304: regulation of mast cell degranulation
GO:0045087: innate immune response
GO:0046777: protein autophosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048041: focal adhesion assembly
GO:0090004: positive regulation of establishment of protein localization to plasma membrane
GO:0097191: extrinsic apoptotic signaling pathway
GO:0005886: plasma membrane
GO:0016020: membrane
GO:0005829: cytosol
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005925: focal adhesion
GO:0016023: cytoplasmic membrane-bounded vesicle
GO:0005515: protein binding
GO:0004674: protein serine/threonine kinase activity
GO:0004676: 3-phosphoinositide-dependent protein kinase activity
GO:0005158: insulin receptor binding
GO:0005524: ATP binding
GO:0016301: kinase activity
GO:0019901: protein kinase binding
KEGG pathways 3320: PPAR signaling pathway
4150: mTOR signaling pathway
4510: Focal adhesion
4910: Insulin signaling pathway
4960: Aldosterone-regulated sodium reabsorption
5213: Endometrial cancer
5215: Prostate cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with PDPK1

PMID Title Tumor Value
15547696 Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. no no
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