Results for PF4

General Information

Gene ID 5196
Gene Symbol PF4
Gene Name platelet factor 4
Gene Type protein-coding
Cytoband 4q12-q21
Ensembl ID ENSG00000163737
#miR regulators 1
Omim ID 173460
Gene ontology GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0006955: immune response
GO:0010628: positive regulation of gene expression
GO:0010744: positive regulation of macrophage derived foam cell differentiation
GO:0016525: negative regulation of angiogenesis
GO:0019221: cytokine-mediated signaling pathway
GO:0030168: platelet activation
GO:0030595: leukocyte chemotaxis
GO:0032760: positive regulation of tumor necrosis factor production
GO:0045347: negative regulation of MHC class II biosynthetic process
GO:0045651: positive regulation of macrophage differentiation
GO:0045653: negative regulation of megakaryocyte differentiation
GO:0045918: negative regulation of cytolysis
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0031093: platelet alpha granule lumen
GO:0008009: chemokine activity
GO:0008201: heparin binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4062: Chemokine signaling pathway

PubMed abstracts associated with PF4

PMID Title Tumor Value
1520309 Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth. no no
20806347 Elevated expression of CXC chemokines in pediatric osteosarcoma patients. yes yes
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