General Information
Gene ID | 5196 |
---|---|
Gene Symbol | PF4 |
Gene Name | platelet factor 4 |
Gene Type | protein-coding |
Cytoband | 4q12-q21 |
Ensembl ID | ENSG00000163737 |
#miR regulators | 1 |
Omim ID | 173460 |
Gene ontology |
GO:0002576: platelet degranulation GO:0007596: blood coagulation GO:0006955: immune response GO:0010628: positive regulation of gene expression GO:0010744: positive regulation of macrophage derived foam cell differentiation GO:0016525: negative regulation of angiogenesis GO:0019221: cytokine-mediated signaling pathway GO:0030168: platelet activation GO:0030595: leukocyte chemotaxis GO:0032760: positive regulation of tumor necrosis factor production GO:0045347: negative regulation of MHC class II biosynthetic process GO:0045651: positive regulation of macrophage differentiation GO:0045653: negative regulation of megakaryocyte differentiation GO:0045918: negative regulation of cytolysis GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005576: extracellular region GO:0005615: extracellular space GO:0031093: platelet alpha granule lumen GO:0008009: chemokine activity GO:0008201: heparin binding |
KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4062: Chemokine signaling pathway |
PMID | Title | Tumor | Value |
---|---|---|---|
1520309 | Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth. | no | no |
20806347 | Elevated expression of CXC chemokines in pediatric osteosarcoma patients. | yes | yes |
title | all | all |