Results for ABCB1

General Information

Gene ID 5243
Gene Symbol ABCB1
Gene Name ATP-binding cassette, sub-family B (MDR/TAP), member 1
Gene Type protein-coding
Cytoband 7q21.12
Ensembl ID ENSG00000085563
#miR regulators 2
Omim ID 120080 171050 612244
Gene ontology GO:0000086: G2/M transition of mitotic cell cycle
GO:0006810: transport
GO:0006855: drug transmembrane transport
GO:0042493: response to drug
GO:0044281: small molecule metabolic process
GO:0055085: transmembrane transport
GO:0072089: stem cell proliferation
GO:0005886: plasma membrane
GO:0000139: Golgi membrane
GO:0016021: integral to membrane
GO:0016020: membrane
GO:0009986: cell surface
GO:0016324: apical plasma membrane
GO:0046581: intercellular canaliculus
GO:0005515: protein binding
GO:0042626: ATPase activity, coupled to transmembrane movement of substances
GO:0005215: transporter activity
GO:0005524: ATP binding
GO:0008559: xenobiotic-transporting ATPase activity
KEGG pathways 2010: ABC transporters
4976: Bile secretion

PubMed abstracts associated with ABCB1

PMID Title Tumor Value
7477118 Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. yes yes
7660382 Expression of the human multidrug resistance gene (MDR1) and prognostic correlation in human osteogenic sarcoma. yes yes
7735558 Correlation of p-glycoprotein detection by immunohistochemistry with mdr-1 mRNA levels in osteosarcomas. Pilot study. yes no
7833115 Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs. yes no
7904171 Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients. yes no
7912235 Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin. no no
8562155 Analysis of P-glycoprotein expression in osteosarcoma. yes yes
8625324 Multidrug resistance and malignancy in human osteosarcoma. yes no
8855972 Quantitative analysis of multidrug resistance gene expression in human osteosarcomas. yes yes
9065577 Expression of P-glycoprotein in high grade osteosarcomas with special emphasis on chondroblastic subtype. yes yes
9228255 P-glycoprotein expression in high grade central osteosarcoma and normal bone cells. An immunohistochemical study. yes no
9390540 P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy. yes yes
9743295 P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. yes no
9748149 Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. no yes
9917506 Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. yes yes
9989824 The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells. no no
10561353 Expression of HER2/erbB-2 correlates with survival in osteosarcoma. yes yes
10569469 P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy. yes yes
10810457 P-glycoprotein levels predict poor outcome in patients with osteosarcoma. yes yes
10894867 MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study. yes no
11294418 The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma. yes yes
11595696 Lack of correlation of functional scintigraphy with (99m)technetium-methoxyisobutylisonitrile with histological necrosis following induction chemotherapy or measures of P-glycoprotein expression in high-grade osteosarcoma. yes yes
11794258 Clinical significance of P-glycoprotein immunohistochemistry and doxorubicin binding assay in patients with osteosarcoma. yes yes
12560446 Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities. yes yes
12789260 Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. no no
12879476 The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. yes yes
14719113 Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells. no no
15112275 Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. yes yes
15547696 Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. no no
15913990 Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma. yes yes
16273216 Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. no no
17045162 Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies. no no
17088985 May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol. yes yes
17279585 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. no no
17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. no no
18510171 Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. no no
19105235 Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. no no
20520719 Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. no no
21287809 Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. no no
21780101 P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. no no
21868524 Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines. no no
22016816 Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study. yes yes
22715593 Overexpression of LIMK1 promotes migration ability of multidrug-resistant osteosarcoma cells. no no
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