General Information
Gene ID | 5243 |
---|---|
Gene Symbol | ABCB1 |
Gene Name | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
Gene Type | protein-coding |
Cytoband | 7q21.12 |
Ensembl ID | ENSG00000085563 |
#miR regulators | 2 |
Omim ID | 120080 171050 612244 |
Gene ontology |
GO:0000086: G2/M transition of mitotic cell cycle GO:0006810: transport GO:0006855: drug transmembrane transport GO:0042493: response to drug GO:0044281: small molecule metabolic process GO:0055085: transmembrane transport GO:0072089: stem cell proliferation GO:0005886: plasma membrane GO:0000139: Golgi membrane GO:0016021: integral to membrane GO:0016020: membrane GO:0009986: cell surface GO:0016324: apical plasma membrane GO:0046581: intercellular canaliculus GO:0005515: protein binding GO:0042626: ATPase activity, coupled to transmembrane movement of substances GO:0005215: transporter activity GO:0005524: ATP binding GO:0008559: xenobiotic-transporting ATPase activity |
KEGG pathways |
2010: ABC transporters 4976: Bile secretion |
PMID | Title | Tumor | Value |
---|---|---|---|
7477118 | Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. | yes | yes |
7660382 | Expression of the human multidrug resistance gene (MDR1) and prognostic correlation in human osteogenic sarcoma. | yes | yes |
7735558 | Correlation of p-glycoprotein detection by immunohistochemistry with mdr-1 mRNA levels in osteosarcomas. Pilot study. | yes | no |
7833115 | Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs. | yes | no |
7904171 | Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients. | yes | no |
7912235 | Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin. | no | no |
8562155 | Analysis of P-glycoprotein expression in osteosarcoma. | yes | yes |
8625324 | Multidrug resistance and malignancy in human osteosarcoma. | yes | no |
8855972 | Quantitative analysis of multidrug resistance gene expression in human osteosarcomas. | yes | yes |
9065577 | Expression of P-glycoprotein in high grade osteosarcomas with special emphasis on chondroblastic subtype. | yes | yes |
9228255 | P-glycoprotein expression in high grade central osteosarcoma and normal bone cells. An immunohistochemical study. | yes | no |
9390540 | P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy. | yes | yes |
9743295 | P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. | yes | no |
9748149 | Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. | no | yes |
9917506 | Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. | yes | yes |
9989824 | The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells. | no | no |
10561353 | Expression of HER2/erbB-2 correlates with survival in osteosarcoma. | yes | yes |
10569469 | P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy. | yes | yes |
10810457 | P-glycoprotein levels predict poor outcome in patients with osteosarcoma. | yes | yes |
10894867 | MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study. | yes | no |
11294418 | The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma. | yes | yes |
11595696 | Lack of correlation of functional scintigraphy with (99m)technetium-methoxyisobutylisonitrile with histological necrosis following induction chemotherapy or measures of P-glycoprotein expression in high-grade osteosarcoma. | yes | yes |
11794258 | Clinical significance of P-glycoprotein immunohistochemistry and doxorubicin binding assay in patients with osteosarcoma. | yes | yes |
12560446 | Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities. | yes | yes |
12789260 | Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. | no | no |
12879476 | The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. | yes | yes |
14719113 | Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells. | no | no |
15112275 | Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. | yes | yes |
15547696 | Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. | no | no |
15913990 | Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma. | yes | yes |
16273216 | Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. | no | no |
17045162 | Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies. | no | no |
17088985 | May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol. | yes | yes |
17279585 | Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. | no | no |
17520676 | Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. | no | no |
18510171 | Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. | no | no |
19105235 | Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. | no | no |
20520719 | Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. | no | no |
21287809 | Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. | no | no |
21780101 | P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. | no | no |
21868524 | Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines. | no | no |
22016816 | Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study. | yes | yes |
22715593 | Overexpression of LIMK1 promotes migration ability of multidrug-resistant osteosarcoma cells. | no | no |
title | all | all |