General Information
| Gene ID | 5290 |
|---|---|
| Gene Symbol | PIK3CA |
| Gene Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Gene Type | protein-coding |
| Cytoband | 3q26.3 |
| Ensembl ID | ENSG00000121879 |
| #miR regulators | 3 |
| Omim ID | 114480 114500 114550 162900 171834 182000 211980 602501 603387 612918 613659 615108 |
| Gene ontology |
GO:0001525: angiogenesis GO:0001944: vasculature development GO:0007596: blood coagulation GO:0006006: glucose metabolic process GO:0006644: phospholipid metabolic process GO:0006661: phosphatidylinositol biosynthetic process GO:0007173: epidermal growth factor receptor signaling pathway GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:0048015: phosphatidylinositol-mediated signaling GO:0050852: T cell receptor signaling pathway GO:0030168: platelet activation GO:0031295: T cell costimulation GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0038028: insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade GO:0038095: Fc-epsilon receptor signaling pathway GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis GO:0040014: regulation of multicellular organism growth GO:0043491: protein kinase B signaling cascade GO:0043542: endothelial cell migration GO:0044029: hypomethylation of CpG island GO:0044281: small molecule metabolic process GO:0045087: innate immune response GO:0046854: phosphatidylinositol phosphorylation GO:0048011: neurotrophin TRK receptor signaling pathway GO:0050900: leukocyte migration GO:0060048: cardiac muscle contraction GO:2000653: regulation of genetic imprinting GO:2000811: negative regulation of anoikis GO:0005886: plasma membrane GO:0005829: cytosol GO:0005942: phosphatidylinositol 3-kinase complex GO:0005943: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex GO:0030027: lamellipodium GO:0005515: protein binding GO:0004674: protein serine/threonine kinase activity GO:0005524: ATP binding GO:0016303: 1-phosphatidylinositol-3-kinase activity GO:0035005: 1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0046934: phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0016301: kinase activity GO:0030295: protein kinase activator activity GO:0035004: phosphatidylinositol 3-kinase activity GO:0043560: insulin receptor substrate binding |
| KEGG pathways |
562: Inositol phosphate metabolism 4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4070: Phosphatidylinositol signaling system 4150: mTOR signaling pathway 4210: Apoptosis 4370: VEGF signaling pathway 4380: Osteoclast differentiation 4510: Focal adhesion 4620: Toll-like receptor signaling pathway 4630: Jak-STAT signaling pathway 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4666: Fc gamma R-mediated phagocytosis 4670: Leukocyte transendothelial migration 4722: Neurotrophin signaling pathway 4810: Regulation of actin cytoskeleton 4910: Insulin signaling pathway 4914: Progesterone-mediated oocyte maturation 4930: Type II diabetes mellitus 4960: Aldosterone-regulated sodium reabsorption 4973: Carbohydrate digestion and absorption 5100: Bacterial invasion of epithelial cells 5142: Chagas disease (American trypanosomiasis) 5145: Toxoplasmosis 5146: Amoebiasis 5160: Hepatitis C 5200: Pathways in cancer 5210: Colorectal cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5222: Small cell lung cancer 5223: Non-small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 16764926 | Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene. | yes | no |
| 22006429 | High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. | yes | no |
| 22387266 | Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. | no | no |
| title | all | all |