Results for PIK3CA

General Information

Gene ID 5290
Gene Symbol PIK3CA
Gene Name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Gene Type protein-coding
Cytoband 3q26.3
Ensembl ID ENSG00000121879
#miR regulators 3
Omim ID 114480 114500 114550 162900 171834 182000 211980 602501 603387 612918 613659 615108
Gene ontology GO:0001525: angiogenesis
GO:0001944: vasculature development
GO:0007596: blood coagulation
GO:0006006: glucose metabolic process
GO:0006644: phospholipid metabolic process
GO:0006661: phosphatidylinositol biosynthetic process
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0048015: phosphatidylinositol-mediated signaling
GO:0050852: T cell receptor signaling pathway
GO:0030168: platelet activation
GO:0031295: T cell costimulation
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0038028: insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040014: regulation of multicellular organism growth
GO:0043491: protein kinase B signaling cascade
GO:0043542: endothelial cell migration
GO:0044029: hypomethylation of CpG island
GO:0044281: small molecule metabolic process
GO:0045087: innate immune response
GO:0046854: phosphatidylinositol phosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050900: leukocyte migration
GO:0060048: cardiac muscle contraction
GO:2000653: regulation of genetic imprinting
GO:2000811: negative regulation of anoikis
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005942: phosphatidylinositol 3-kinase complex
GO:0005943: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
GO:0030027: lamellipodium
GO:0005515: protein binding
GO:0004674: protein serine/threonine kinase activity
GO:0005524: ATP binding
GO:0016303: 1-phosphatidylinositol-3-kinase activity
GO:0035005: 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0046934: phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0016301: kinase activity
GO:0030295: protein kinase activator activity
GO:0035004: phosphatidylinositol 3-kinase activity
GO:0043560: insulin receptor substrate binding
KEGG pathways 562: Inositol phosphate metabolism
4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4070: Phosphatidylinositol signaling system
4150: mTOR signaling pathway
4210: Apoptosis
4370: VEGF signaling pathway
4380: Osteoclast differentiation
4510: Focal adhesion
4620: Toll-like receptor signaling pathway
4630: Jak-STAT signaling pathway
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4666: Fc gamma R-mediated phagocytosis
4670: Leukocyte transendothelial migration
4722: Neurotrophin signaling pathway
4810: Regulation of actin cytoskeleton
4910: Insulin signaling pathway
4914: Progesterone-mediated oocyte maturation
4930: Type II diabetes mellitus
4960: Aldosterone-regulated sodium reabsorption
4973: Carbohydrate digestion and absorption
5100: Bacterial invasion of epithelial cells
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5146: Amoebiasis
5160: Hepatitis C
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5222: Small cell lung cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with PIK3CA

PMID Title Tumor Value
16764926 Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene. yes no
22006429 High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. yes no
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
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