General Information
| Gene ID | 5295 |
|---|---|
| Gene Symbol | PIK3R1 |
| Gene Name | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
| Gene Type | protein-coding |
| Cytoband | 5q13.1 |
| Ensembl ID | ENSG00000145675 |
| #miR regulators | 13 |
| Omim ID | 171833 269880 615214 |
| Gene ontology |
GO:0001953: negative regulation of cell-matrix adhesion GO:0007596: blood coagulation GO:0006468: protein phosphorylation GO:0006644: phospholipid metabolic process GO:0006661: phosphatidylinositol biosynthetic process GO:0007173: epidermal growth factor receptor signaling pathway GO:0043066: negative regulation of apoptotic process GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:0014065: phosphatidylinositol 3-kinase cascade GO:0046326: positive regulation of glucose import GO:0019048: modulation by virus of host morphology or physiology GO:0048015: phosphatidylinositol-mediated signaling GO:0050852: T cell receptor signaling pathway GO:0030168: platelet activation GO:0030183: B cell differentiation GO:0030335: positive regulation of cell migration GO:0031295: T cell costimulation GO:0034644: cellular response to UV GO:0038095: Fc-epsilon receptor signaling pathway GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis GO:0043065: positive regulation of apoptotic process GO:0043551: regulation of phosphatidylinositol 3-kinase activity GO:0044281: small molecule metabolic process GO:0045087: innate immune response GO:0045671: negative regulation of osteoclast differentiation GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046854: phosphatidylinositol phosphorylation GO:0048009: insulin-like growth factor receptor signaling pathway GO:0048011: neurotrophin TRK receptor signaling pathway GO:0050900: leukocyte migration GO:0051531: NFAT protein import into nucleus GO:0060396: growth hormone receptor signaling pathway GO:0090004: positive regulation of establishment of protein localization to plasma membrane GO:0005886: plasma membrane GO:0005829: cytosol GO:0005942: phosphatidylinositol 3-kinase complex GO:0005943: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex GO:0005515: protein binding GO:0043125: ErbB-3 class receptor binding GO:0005068: transmembrane receptor protein tyrosine kinase adaptor activity GO:0005158: insulin receptor binding GO:0005159: insulin-like growth factor receptor binding GO:0005168: neurotrophin TRKA receptor binding GO:0005545: 1-phosphatidylinositol binding GO:0019903: protein phosphatase binding GO:0035014: phosphatidylinositol 3-kinase regulator activity GO:0043548: phosphatidylinositol 3-kinase binding GO:0043559: insulin binding GO:0043560: insulin receptor substrate binding |
| KEGG pathways |
4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4070: Phosphatidylinositol signaling system 4150: mTOR signaling pathway 4210: Apoptosis 4370: VEGF signaling pathway 4380: Osteoclast differentiation 4510: Focal adhesion 4620: Toll-like receptor signaling pathway 4630: Jak-STAT signaling pathway 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4666: Fc gamma R-mediated phagocytosis 4670: Leukocyte transendothelial migration 4722: Neurotrophin signaling pathway 4810: Regulation of actin cytoskeleton 4910: Insulin signaling pathway 4914: Progesterone-mediated oocyte maturation 4930: Type II diabetes mellitus 4960: Aldosterone-regulated sodium reabsorption 4973: Carbohydrate digestion and absorption 5100: Bacterial invasion of epithelial cells 5142: Chagas disease (American trypanosomiasis) 5145: Toxoplasmosis 5146: Amoebiasis 5160: Hepatitis C 5200: Pathways in cancer 5210: Colorectal cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5222: Small cell lung cancer 5223: Non-small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 23133552 | Modulation of the osteosarcoma expression phenotype by microRNAs. | yes | no |
| title | all | all |