Results for PLAU

General Information

Gene ID 5328
Gene Symbol PLAU
Gene Name plasminogen activator, urokinase
Gene Type protein-coding
Cytoband 10q22.2
Ensembl ID ENSG00000122861
#miR regulators 9
Omim ID 104300 191840 601709
Gene ontology GO:0001666: response to hypoxia
GO:0007596: blood coagulation
GO:0007165: signal transduction
GO:0006508: proteolysis
GO:0006935: chemotaxis
GO:0010469: regulation of receptor activity
GO:0014909: smooth muscle cell migration
GO:0014910: regulation of smooth muscle cell migration
GO:0033628: regulation of cell adhesion mediated by integrin
GO:0042127: regulation of cell proliferation
GO:0042730: fibrinolysis
GO:0061041: regulation of wound healing
GO:2000097: regulation of smooth muscle cell-matrix adhesion
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0009986: cell surface
GO:0005515: protein binding
GO:0004252: serine-type endopeptidase activity
KEGG pathways 4610: Complement and coagulation cascades

PubMed abstracts associated with PLAU

PMID Title Tumor Value
1481722 The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63. no no
7502710 Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. no no
7826985 Plasminogen activators and their inhibitor in osteosarcomas and other bone tumors. yes no
8391387 Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. no no
9258335 Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. no no
9639407 Antisense inhibition of urokinase: effect on malignancy in a human osteosarcoma cell line. no no
10086509 Protease expression in dedifferentiated parosteal osteosarcoma. yes no
10807968 Effect of hyperthermia on the viability and the fibrinolytic potential of human cancer cell lines. no no
11713566 Plasminogen activators and their inhibitor in bone tumors and tumor-like damages. yes no
15095405 IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. no no
16008557 Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. yes no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
18758062 Proteome profiling of U2OS cell line in response to a prenylphenol antibiotic isolated from a phytopathogenic fungus. no no
21283769 Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1. yes no
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