General Information
Gene ID | 5328 |
---|---|
Gene Symbol | PLAU |
Gene Name | plasminogen activator, urokinase |
Gene Type | protein-coding |
Cytoband | 10q22.2 |
Ensembl ID | ENSG00000122861 |
#miR regulators | 9 |
Omim ID | 104300 191840 601709 |
Gene ontology |
GO:0001666: response to hypoxia GO:0007596: blood coagulation GO:0007165: signal transduction GO:0006508: proteolysis GO:0006935: chemotaxis GO:0010469: regulation of receptor activity GO:0014909: smooth muscle cell migration GO:0014910: regulation of smooth muscle cell migration GO:0033628: regulation of cell adhesion mediated by integrin GO:0042127: regulation of cell proliferation GO:0042730: fibrinolysis GO:0061041: regulation of wound healing GO:2000097: regulation of smooth muscle cell-matrix adhesion GO:0005886: plasma membrane GO:0005576: extracellular region GO:0005615: extracellular space GO:0009986: cell surface GO:0005515: protein binding GO:0004252: serine-type endopeptidase activity |
KEGG pathways |
4610: Complement and coagulation cascades |
PMID | Title | Tumor | Value |
---|---|---|---|
1481722 | The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63. | no | no |
7502710 | Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. | no | no |
7826985 | Plasminogen activators and their inhibitor in osteosarcomas and other bone tumors. | yes | no |
8391387 | Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. | no | no |
9258335 | Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. | no | no |
9639407 | Antisense inhibition of urokinase: effect on malignancy in a human osteosarcoma cell line. | no | no |
10086509 | Protease expression in dedifferentiated parosteal osteosarcoma. | yes | no |
10807968 | Effect of hyperthermia on the viability and the fibrinolytic potential of human cancer cell lines. | no | no |
11713566 | Plasminogen activators and their inhibitor in bone tumors and tumor-like damages. | yes | no |
15095405 | IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. | no | no |
16008557 | Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. | yes | no |
17116726 | Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. | no | no |
18758062 | Proteome profiling of U2OS cell line in response to a prenylphenol antibiotic isolated from a phytopathogenic fungus. | no | no |
21283769 | Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1. | yes | no |
title | all | all |