General Information
Gene ID | 5347 |
---|---|
Gene Symbol | PLK1 |
Gene Name | polo-like kinase 1 |
Gene Type | protein-coding |
Cytoband | 16p12.2 |
Ensembl ID | ENSG00000166851 |
#miR regulators | --- |
Omim ID | 602098 |
Gene ontology |
GO:0000070: mitotic sister chromatid segregation GO:0000086: G2/M transition of mitotic cell cycle GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000278: mitotic cell cycle GO:0000910: cytokinesis GO:0001578: microtubule bundle formation GO:0051726: regulation of cell cycle GO:0016567: protein ubiquitination GO:0006468: protein phosphorylation GO:0007067: mitosis GO:0007077: mitotic nuclear envelope disassembly GO:0007091: metaphase/anaphase transition of mitotic cell cycle GO:0007092: activation of mitotic anaphase-promoting complex activity GO:0007094: mitotic spindle assembly checkpoint GO:0007346: regulation of mitotic cell cycle GO:0043066: negative regulation of apoptotic process GO:0008283: cell proliferation GO:0010800: positive regulation of peptidyl-threonine phosphorylation GO:0018105: peptidyl-serine phosphorylation GO:0030071: regulation of mitotic metaphase/anaphase transition GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031572: G2 DNA damage checkpoint GO:0031648: protein destabilization GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043393: regulation of protein binding GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045862: positive regulation of proteolysis GO:0051297: centrosome organization GO:0051437: positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051443: positive regulation of ubiquitin-protein ligase activity GO:0071168: protein localization to chromatin GO:0000776: kinetochore GO:0000922: spindle pole GO:0000942: condensed nuclear chromosome outer kinetochore GO:0005829: cytosol GO:0005634: nucleus GO:0005654: nucleoplasm GO:0005813: centrosome GO:0005819: spindle GO:0005876: spindle microtubule GO:0030496: midbody GO:0051233: spindle midzone GO:0005515: protein binding GO:0004672: protein kinase activity GO:0004674: protein serine/threonine kinase activity GO:0005524: ATP binding GO:0008017: microtubule binding GO:0010997: anaphase-promoting complex binding GO:0016301: kinase activity GO:0019901: protein kinase binding |
KEGG pathways |
4110: Cell cycle 4114: Oocyte meiosis 4914: Progesterone-mediated oocyte maturation |
PMID | Title | Tumor | Value |
---|---|---|---|
20144850 | Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. | no | yes |
21399492 | Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. | no | no |
21822121 | BI 2536-mediated PLK1 inhibition suppresses HOS and MG-63 osteosarcoma cell line growth and clonogenicity. | no | no |
title | all | all |