Results for PLK1

General Information

Gene ID 5347
Gene Symbol PLK1
Gene Name polo-like kinase 1
Gene Type protein-coding
Cytoband 16p12.2
Ensembl ID ENSG00000166851
#miR regulators ---
Omim ID 602098
Gene ontology GO:0000070: mitotic sister chromatid segregation
GO:0000086: G2/M transition of mitotic cell cycle
GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000278: mitotic cell cycle
GO:0000910: cytokinesis
GO:0001578: microtubule bundle formation
GO:0051726: regulation of cell cycle
GO:0016567: protein ubiquitination
GO:0006468: protein phosphorylation
GO:0007067: mitosis
GO:0007077: mitotic nuclear envelope disassembly
GO:0007091: metaphase/anaphase transition of mitotic cell cycle
GO:0007092: activation of mitotic anaphase-promoting complex activity
GO:0007094: mitotic spindle assembly checkpoint
GO:0007346: regulation of mitotic cell cycle
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0010800: positive regulation of peptidyl-threonine phosphorylation
GO:0018105: peptidyl-serine phosphorylation
GO:0030071: regulation of mitotic metaphase/anaphase transition
GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572: G2 DNA damage checkpoint
GO:0031648: protein destabilization
GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043393: regulation of protein binding
GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862: positive regulation of proteolysis
GO:0051297: centrosome organization
GO:0051437: positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051443: positive regulation of ubiquitin-protein ligase activity
GO:0071168: protein localization to chromatin
GO:0000776: kinetochore
GO:0000922: spindle pole
GO:0000942: condensed nuclear chromosome outer kinetochore
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005813: centrosome
GO:0005819: spindle
GO:0005876: spindle microtubule
GO:0030496: midbody
GO:0051233: spindle midzone
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004674: protein serine/threonine kinase activity
GO:0005524: ATP binding
GO:0008017: microtubule binding
GO:0010997: anaphase-promoting complex binding
GO:0016301: kinase activity
GO:0019901: protein kinase binding
KEGG pathways 4110: Cell cycle
4114: Oocyte meiosis
4914: Progesterone-mediated oocyte maturation

PubMed abstracts associated with PLK1

PMID Title Tumor Value
20144850 Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. no yes
21399492 Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. no no
21822121 BI 2536-mediated PLK1 inhibition suppresses HOS and MG-63 osteosarcoma cell line growth and clonogenicity. no no
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