Results for CYCS

General Information

Gene ID 54205
Gene Symbol CYCS
Gene Name cytochrome c, somatic
Gene Type protein-coding
Cytoband 7p15.3
Ensembl ID ENSG00000172115
#miR regulators 13
Omim ID 123970 612004
Gene ontology GO:0006915: apoptotic process
GO:0022904: respiratory electron transport chain
GO:0006309: apoptotic DNA fragmentation
GO:0008635: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0044237: cellular metabolic process
GO:0044281: small molecule metabolic process
GO:0045333: cellular respiration
GO:0097193: intrinsic apoptotic signaling pathway
GO:0000159: protein phosphatase type 2A complex
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005743: mitochondrial inner membrane
GO:0005758: mitochondrial intermembrane space
GO:0070469: respiratory chain
GO:0005515: protein binding
GO:0004722: protein serine/threonine phosphatase activity
GO:0005506: iron ion binding
GO:0045155: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
GO:0020037: heme binding
KEGG pathways 4115: p53 signaling pathway
4210: Apoptosis
5010: Alzheimer's disease
5012: Parkinson's disease
5014: Amyotrophic lateral sclerosis (ALS)
5016: Huntington's disease
5145: Toxoplasmosis
5200: Pathways in cancer
5210: Colorectal cancer
5222: Small cell lung cancer
5416: Viral myocarditis

PubMed abstracts associated with CYCS

PMID Title Tumor Value
10702275 Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. no no
11306692 The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. no no
11513857 The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. no no
12616540 Alpha 4 integrin increases anoikis of human osteosarcoma cells. yes no
15314286 Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. no no
15816563 Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. no no
15936998 Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. no no
15965098 Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. no no
16167336 Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. no no
16213662 Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. no no
17218775 Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. no no
17356895 Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. no no
17471233 Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. no no
18158779 Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. yes yes
18510171 Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. no no
19746447 Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. no no
19757179 beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. no no
21163271 Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. no no
21490307 The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. no no
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no
21617882 Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. no no
21805050 Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. no no
22009832 Apoptotic effects of curcumin on human osteosarcoma U2OS cells. no no
22231496 Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no
22246399 Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. no no
23091618 Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. no no
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
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