General Information
Gene ID | 54205 |
---|---|
Gene Symbol | CYCS |
Gene Name | cytochrome c, somatic |
Gene Type | protein-coding |
Cytoband | 7p15.3 |
Ensembl ID | ENSG00000172115 |
#miR regulators | 13 |
Omim ID | 123970 612004 |
Gene ontology |
GO:0006915: apoptotic process GO:0022904: respiratory electron transport chain GO:0006309: apoptotic DNA fragmentation GO:0008635: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0044237: cellular metabolic process GO:0044281: small molecule metabolic process GO:0045333: cellular respiration GO:0097193: intrinsic apoptotic signaling pathway GO:0000159: protein phosphatase type 2A complex GO:0005829: cytosol GO:0005634: nucleus GO:0005743: mitochondrial inner membrane GO:0005758: mitochondrial intermembrane space GO:0070469: respiratory chain GO:0005515: protein binding GO:0004722: protein serine/threonine phosphatase activity GO:0005506: iron ion binding GO:0045155: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity GO:0020037: heme binding |
KEGG pathways |
4115: p53 signaling pathway 4210: Apoptosis 5010: Alzheimer's disease 5012: Parkinson's disease 5014: Amyotrophic lateral sclerosis (ALS) 5016: Huntington's disease 5145: Toxoplasmosis 5200: Pathways in cancer 5210: Colorectal cancer 5222: Small cell lung cancer 5416: Viral myocarditis |
PMID | Title | Tumor | Value |
---|---|---|---|
10702275 | Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. | no | no |
11306692 | The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. | no | no |
11513857 | The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. | no | no |
12616540 | Alpha 4 integrin increases anoikis of human osteosarcoma cells. | yes | no |
15314286 | Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. | no | no |
15816563 | Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. | no | no |
15936998 | Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. | no | no |
15965098 | Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. | no | no |
16167336 | Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. | no | no |
16213662 | Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. | no | no |
17218775 | Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. | no | no |
17356895 | Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. | no | no |
17471233 | Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. | no | no |
18158779 | Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. | yes | yes |
18510171 | Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. | no | no |
19746447 | Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. | no | no |
19757179 | beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. | no | no |
21163271 | Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. | no | no |
21490307 | The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. | no | no |
21573491 | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | no | no |
21617882 | Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. | no | no |
21805050 | Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. | no | no |
22009832 | Apoptotic effects of curcumin on human osteosarcoma U2OS cells. | no | no |
22231496 | Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no |
22246399 | Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. | no | no |
23091618 | Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. | no | no |
23313376 | Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. | no | no |
title | all | all |