General Information
| Gene ID | 545 |
|---|---|
| Gene Symbol | ATR |
| Gene Name | ataxia telangiectasia and Rad3 related |
| Gene Type | protein-coding |
| Cytoband | 3q23 |
| Ensembl ID | ENSG00000175054 |
| #miR regulators | --- |
| Omim ID | 210600 601215 614564 |
| Gene ontology |
GO:0006260: DNA replication GO:0000077: DNA damage checkpoint GO:0006281: DNA repair GO:0006974: response to DNA damage stimulus GO:0007049: cell cycle GO:0007275: multicellular organismal development GO:0008156: negative regulation of DNA replication GO:0018105: peptidyl-serine phosphorylation GO:0034644: cellular response to UV GO:0043393: regulation of protein binding GO:0043517: positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0046777: protein autophosphorylation GO:0071480: cellular response to gamma radiation GO:0090399: replicative senescence GO:0001741: XY body GO:0005654: nucleoplasm GO:0005694: chromosome GO:0016605: PML body GO:0005515: protein binding GO:0003677: DNA binding GO:0004672: protein kinase activity GO:0004674: protein serine/threonine kinase activity GO:0005524: ATP binding GO:0032405: MutLalpha complex binding GO:0032407: MutSalpha complex binding |
| KEGG pathways |
4110: Cell cycle 4115: p53 signaling pathway |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 15705874 | Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. | no | no |
| title | all | all |