Results for POU5F1

General Information

Gene ID 5460
Gene Symbol POU5F1
Gene Name POU class 5 homeobox 1
Gene Type protein-coding
Cytoband 6p21.31
Ensembl ID ENSG00000204531 ENSG00000237582 ENSG00000230336 ENSG00000235068 ENSG00000229094 ENSG00000206454 ENSG00000233911
#miR regulators ---
Omim ID 164177
Gene ontology GO:0001714: endodermal cell fate specification
GO:0001824: blastocyst development
GO:0003130: BMP signaling pathway involved in heart induction
GO:0006366: transcription from RNA polymerase II promoter
GO:0006355: regulation of transcription, DNA-dependent
GO:0009653: anatomical structure morphogenesis
GO:0009611: response to wounding
GO:0009786: regulation of asymmetric cell division
GO:0010468: regulation of gene expression
GO:0035019: somatic stem cell maintenance
GO:0035413: positive regulation of catenin import into nucleus
GO:0042789: mRNA transcription from RNA polymerase II promoter
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0060391: positive regulation of SMAD protein import into nucleus
GO:0060795: cell fate commitment involved in formation of primary germ layer
GO:0060913: cardiac cell fate determination
GO:0060965: negative regulation of gene silencing by miRNA
GO:0090081: regulation of heart induction by regulation of canonical Wnt receptor signaling pathway
GO:0090308: regulation of methylation-dependent chromatin silencing
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005515: protein binding
GO:0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677: DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0008134: transcription factor binding
GO:0044212: transcription regulatory region DNA binding
GO:0031625: ubiquitin protein ligase binding
GO:0035198: miRNA binding
GO:0043565: sequence-specific DNA binding
KEGG pathways ---

PubMed abstracts associated with POU5F1

PMID Title Tumor Value
18332870 Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. no no
19160414 Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. no no
19242128 Characterization of stem cell attributes in human osteosarcoma cell lines. no no
19584295 Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. no no
20309879 Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. no no
20596639 Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. no no
21178508 BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. no no
22870217 Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. no no
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