General Information
Gene ID | 5460 |
---|---|
Gene Symbol | POU5F1 |
Gene Name | POU class 5 homeobox 1 |
Gene Type | protein-coding |
Cytoband | 6p21.31 |
Ensembl ID | ENSG00000204531 ENSG00000237582 ENSG00000230336 ENSG00000235068 ENSG00000229094 ENSG00000206454 ENSG00000233911 |
#miR regulators | --- |
Omim ID | 164177 |
Gene ontology |
GO:0001714: endodermal cell fate specification GO:0001824: blastocyst development GO:0003130: BMP signaling pathway involved in heart induction GO:0006366: transcription from RNA polymerase II promoter GO:0006355: regulation of transcription, DNA-dependent GO:0009653: anatomical structure morphogenesis GO:0009611: response to wounding GO:0009786: regulation of asymmetric cell division GO:0010468: regulation of gene expression GO:0035019: somatic stem cell maintenance GO:0035413: positive regulation of catenin import into nucleus GO:0042789: mRNA transcription from RNA polymerase II promoter GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0060391: positive regulation of SMAD protein import into nucleus GO:0060795: cell fate commitment involved in formation of primary germ layer GO:0060913: cardiac cell fate determination GO:0060965: negative regulation of gene silencing by miRNA GO:0090081: regulation of heart induction by regulation of canonical Wnt receptor signaling pathway GO:0090308: regulation of methylation-dependent chromatin silencing GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005667: transcription factor complex GO:0005515: protein binding GO:0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0003677: DNA binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0008134: transcription factor binding GO:0044212: transcription regulatory region DNA binding GO:0031625: ubiquitin protein ligase binding GO:0035198: miRNA binding GO:0043565: sequence-specific DNA binding |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
18332870 | Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. | no | no |
19160414 | Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. | no | no |
19242128 | Characterization of stem cell attributes in human osteosarcoma cell lines. | no | no |
19584295 | Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. | no | no |
20309879 | Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. | no | no |
20596639 | Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. | no | no |
21178508 | BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. | no | no |
22870217 | Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. | no | no |
title | all | all |