General Information
Gene ID | 55294 |
---|---|
Gene Symbol | FBXW7 |
Gene Name | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
Gene Type | protein-coding |
Cytoband | 4q31.3 |
Ensembl ID | ENSG00000109670 |
#miR regulators | 17 |
Omim ID | 606278 |
Gene ontology |
GO:0001570: vasculogenesis GO:0001944: vasculature development GO:0045741: positive regulation of epidermal growth factor-activated receptor activity GO:0016567: protein ubiquitination GO:0006974: response to DNA damage stimulus GO:0007062: sister chromatid cohesion GO:0007219: Notch signaling pathway GO:0010868: negative regulation of triglyceride biosynthetic process GO:0010883: regulation of lipid storage GO:0050821: protein stabilization GO:0019048: modulation by virus of host morphology or physiology GO:0030324: lung development GO:0031146: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0032876: negative regulation of DNA endoreduplication GO:0032880: regulation of protein localization GO:0034644: cellular response to UV GO:0045746: negative regulation of Notch signaling pathway GO:0055088: lipid homeostasis GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:2000060: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000346: negative regulation of hepatocyte proliferation GO:2000639: negative regulation of SREBP signaling pathway GO:0005783: endoplasmic reticulum GO:0005654: nucleoplasm GO:0005730: nucleolus GO:0005794: Golgi apparatus GO:0019005: SCF ubiquitin ligase complex GO:0043234: protein complex GO:0005515: protein binding GO:0003700: sequence-specific DNA binding transcription factor activity |
KEGG pathways |
4120: Ubiquitin mediated proteolysis |
PMID | Title | Tumor | Value |
---|---|---|---|
16938571 | hCDC4 variation in osteosarcoma. | yes | no |
title | all | all |