Results for PRKCA

General Information

Gene ID 5578
Gene Symbol PRKCA
Gene Name protein kinase C, alpha
Gene Type protein-coding
Cytoband 17q22-q23.2
Ensembl ID ENSG00000154229
#miR regulators 5
Omim ID 176960
Gene ontology GO:0000188: inactivation of MAPK activity
GO:0001525: angiogenesis
GO:0001934: positive regulation of protein phosphorylation
GO:0001938: positive regulation of endothelial cell proliferation
GO:0002026: regulation of the force of heart contraction
GO:0002062: chondrocyte differentiation
GO:0002159: desmosome assembly
GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0007165: signal transduction
GO:0006112: energy reserve metabolic process
GO:0006468: protein phosphorylation
GO:0006874: cellular calcium ion homeostasis
GO:0006937: regulation of muscle contraction
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007190: activation of adenylate cyclase activity
GO:0007194: negative regulation of adenylate cyclase activity
GO:0007202: activation of phospholipase C activity
GO:0007268: synaptic transmission
GO:0007603: phototransduction, visible light
GO:0050796: regulation of insulin secretion
GO:0008285: negative regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010467: gene expression
GO:0010595: positive regulation of endothelial cell migration
GO:0010613: positive regulation of cardiac muscle hypertrophy
GO:0016056: rhodopsin mediated signaling pathway
GO:0016070: RNA metabolic process
GO:0016071: mRNA metabolic process
GO:0022400: regulation of rhodopsin mediated signaling pathway
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030593: neutrophil chemotaxis
GO:0031666: positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351: negative regulation of glial cell apoptotic process
GO:0035408: histone H3-T6 phosphorylation
GO:0043536: positive regulation of blood vessel endothelial cell migration
GO:0044281: small molecule metabolic process
GO:0045087: innate immune response
GO:0045651: positive regulation of macrophage differentiation
GO:0045766: positive regulation of angiogenesis
GO:0045785: positive regulation of cell adhesion
GO:0045931: positive regulation of mitotic cell cycle
GO:0046325: negative regulation of glucose import
GO:0046627: negative regulation of insulin receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050729: positive regulation of inflammatory response
GO:0050730: regulation of peptidyl-tyrosine phosphorylation
GO:0050930: induction of positive chemotaxis
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0070555: response to interleukin-1
GO:0071322: cellular response to carbohydrate stimulus
GO:0090330: regulation of platelet aggregation
GO:0097190: apoptotic signaling pathway
GO:0097193: intrinsic apoptotic signaling pathway
GO:2000707: positive regulation of dense core granule biogenesis
GO:0005886: plasma membrane
GO:0001750: photoreceptor outer segment
GO:0005829: cytosol
GO:0005783: endoplasmic reticulum
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0030425: dendrite
GO:0031966: mitochondrial membrane
GO:0043025: neuronal cell body
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004697: protein kinase C activity
GO:0004698: calcium-dependent protein kinase C activity
GO:0005524: ATP binding
GO:0008270: zinc ion binding
GO:0019899: enzyme binding
GO:0035403: histone kinase activity (H3-T6 specific)
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4020: Calcium signaling pathway
4070: Phosphatidylinositol signaling system
4270: Vascular smooth muscle contraction
4310: Wnt signaling pathway
4370: VEGF signaling pathway
4510: Focal adhesion
4530: Tight junction
4540: Gap junction
4650: Natural killer cell mediated cytotoxicity
4664: Fc epsilon RI signaling pathway
4666: Fc gamma R-mediated phagocytosis
4670: Leukocyte transendothelial migration
4720: Long-term potentiation
4730: Long-term depression
4912: GnRH signaling pathway
4916: Melanogenesis
4960: Aldosterone-regulated sodium reabsorption
4970: Salivary secretion
4971: Gastric acid secretion
4972: Pancreatic secretion
5110: Vibrio cholerae infection
5130: Pathogenic Escherichia coli infection
5143: African trypanosomiasis
5146: Amoebiasis
5200: Pathways in cancer
5214: Glioma
5223: Non-small cell lung cancer

PubMed abstracts associated with PRKCA

PMID Title Tumor Value
7794813 Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. no no
8123038 Vinblastine-dependent down-modulation of TNF receptors in human osteosarcoma cells is mediated by protein kinase C activity. no no
8402575 Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells. no no
17120184 Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. no no
17189270 alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. no no
18507025 Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412. no no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
19060919 The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. no no
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
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