General Information
Gene ID | 5595 |
---|---|
Gene Symbol | MAPK3 |
Gene Name | mitogen-activated protein kinase 3 |
Gene Type | protein-coding |
Cytoband | 16p11.2 |
Ensembl ID | ENSG00000102882 |
#miR regulators | 6 |
Omim ID | 601795 |
Gene ontology |
GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0000187: activation of MAPK activity GO:0001934: positive regulation of protein phosphorylation GO:0002224: toll-like receptor signaling pathway GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0006360: transcription from RNA polymerase I promoter GO:0007596: blood coagulation GO:0006915: apoptotic process GO:0006361: transcription initiation from RNA polymerase I promoter GO:0006468: protein phosphorylation GO:0006974: response to DNA damage stimulus GO:0007049: cell cycle GO:0007173: epidermal growth factor receptor signaling pathway GO:0007264: small GTPase mediated signal transduction GO:0007265: Ras protein signal transduction GO:0009887: organ morphogenesis GO:0007411: axon guidance GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:0010467: gene expression GO:0016310: phosphorylation GO:0019048: modulation by virus of host morphology or physiology GO:0019221: cytokine-mediated signaling pathway GO:0019233: sensory perception of pain GO:0071260: cellular response to mechanical stimulus GO:0030168: platelet activation GO:0030509: BMP signaling pathway GO:0031663: lipopolysaccharide-mediated signaling pathway GO:0032872: regulation of stress-activated MAPK cascade GO:0033129: positive regulation of histone phosphorylation GO:0034134: toll-like receptor 2 signaling pathway GO:0034138: toll-like receptor 3 signaling pathway GO:0034142: toll-like receptor 4 signaling pathway GO:0034146: toll-like receptor 5 signaling pathway GO:0034162: toll-like receptor 9 signaling pathway GO:0034166: toll-like receptor 10 signaling pathway GO:0035066: positive regulation of histone acetylation GO:0035666: TRIF-dependent toll-like receptor signaling pathway GO:0038083: peptidyl-tyrosine autophosphorylation GO:0038095: Fc-epsilon receptor signaling pathway GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway GO:0043330: response to exogenous dsRNA GO:0045087: innate immune response GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048011: neurotrophin TRK receptor signaling pathway GO:0051090: regulation of sequence-specific DNA binding transcription factor activity GO:0051216: cartilage development GO:0051403: stress-activated MAPK cascade GO:0051493: regulation of cytoskeleton organization GO:0060397: JAK-STAT cascade involved in growth hormone signaling pathway GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0070498: interleukin-1-mediated signaling pathway GO:0070849: response to epidermal growth factor stimulus GO:0072584: caveolin-mediated endocytosis GO:0090170: regulation of Golgi inheritance GO:2000641: regulation of early endosome to late endosome transport GO:2000657: negative regulation of apolipoprotein binding GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005654: nucleoplasm GO:0005769: early endosome GO:0005770: late endosome GO:0005794: Golgi apparatus GO:0005856: cytoskeleton GO:0005901: caveola GO:0005925: focal adhesion GO:0015630: microtubule cytoskeleton GO:0031143: pseudopodium GO:0005515: protein binding GO:0001784: phosphotyrosine binding GO:0004707: MAP kinase activity GO:0005524: ATP binding GO:0019902: phosphatase binding |
KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4114: Oocyte meiosis 4150: mTOR signaling pathway 4270: Vascular smooth muscle contraction 4320: Dorso-ventral axis formation 4350: TGF-beta signaling pathway 4360: Axon guidance 4370: VEGF signaling pathway 4380: Osteoclast differentiation 4510: Focal adhesion 4520: Adherens junction 4540: Gap junction 4620: Toll-like receptor signaling pathway 4621: NOD-like receptor signaling pathway 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4666: Fc gamma R-mediated phagocytosis 4720: Long-term potentiation 4722: Neurotrophin signaling pathway 4730: Long-term depression 4810: Regulation of actin cytoskeleton 4910: Insulin signaling pathway 4912: GnRH signaling pathway 4914: Progesterone-mediated oocyte maturation 4916: Melanogenesis 4930: Type II diabetes mellitus 4960: Aldosterone-regulated sodium reabsorption 5010: Alzheimer's disease 5020: Prion diseases 5131: Shigellosis 5140: Leishmaniasis 5142: Chagas disease (American trypanosomiasis) 5145: Toxoplasmosis 5160: Hepatitis C 5200: Pathways in cancer 5210: Colorectal cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5216: Thyroid cancer 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5223: Non-small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
9100584 | Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells. | no | no |
10234573 | ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. | no | no |
12388161 | 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. | no | no |
15144225 | Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. | no | no |
15268905 | Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation. | no | no |
16007340 | Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. | no | no |
16470222 | RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. | no | no |
16814113 | Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. | no | no |
17116726 | Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. | no | no |
17323424 | Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. | no | no |
17412493 | 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. | no | no |
17513610 | Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. | no | no |
18332870 | Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. | no | no |
18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no |
18814141 | Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. | no | no |
18986328 | Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. | no | no |
19212684 | The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. | yes | yes |
19393247 | Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. | no | no |
20003259 | Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. | yes | no |
20406948 | Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. | no | no |
20460760 | Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. | no | no |
20592496 | Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. | no | no |
21236332 | 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. | no | no |
21440986 | Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. | no | no |
21667022 | The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. | no | no |
22179790 | RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro. | no | no |
22387266 | Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. | no | no |
22525461 | Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. | yes | no |
22674530 | Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. | no | no |
22688575 | Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. | no | no |
22935974 | Mitogen-activated protein kinase pathway in osteosarcoma. | yes | yes |
22993301 | Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. | no | no |
22849560 | Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. | no | no |
23201449 | Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. | no | no |
23262982 | Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. | no | no |
23507142 | miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. | yes | no |
title | all | all |