Results for MAPK3

General Information

Gene ID 5595
Gene Symbol MAPK3
Gene Name mitogen-activated protein kinase 3
Gene Type protein-coding
Cytoband 16p11.2
Ensembl ID ENSG00000102882
#miR regulators 6
Omim ID 601795
Gene ontology GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0000187: activation of MAPK activity
GO:0001934: positive regulation of protein phosphorylation
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006360: transcription from RNA polymerase I promoter
GO:0007596: blood coagulation
GO:0006915: apoptotic process
GO:0006361: transcription initiation from RNA polymerase I promoter
GO:0006468: protein phosphorylation
GO:0006974: response to DNA damage stimulus
GO:0007049: cell cycle
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007264: small GTPase mediated signal transduction
GO:0007265: Ras protein signal transduction
GO:0009887: organ morphogenesis
GO:0007411: axon guidance
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010467: gene expression
GO:0016310: phosphorylation
GO:0019048: modulation by virus of host morphology or physiology
GO:0019221: cytokine-mediated signaling pathway
GO:0019233: sensory perception of pain
GO:0071260: cellular response to mechanical stimulus
GO:0030168: platelet activation
GO:0030509: BMP signaling pathway
GO:0031663: lipopolysaccharide-mediated signaling pathway
GO:0032872: regulation of stress-activated MAPK cascade
GO:0033129: positive regulation of histone phosphorylation
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035066: positive regulation of histone acetylation
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0038083: peptidyl-tyrosine autophosphorylation
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0043330: response to exogenous dsRNA
GO:0045087: innate immune response
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0051090: regulation of sequence-specific DNA binding transcription factor activity
GO:0051216: cartilage development
GO:0051403: stress-activated MAPK cascade
GO:0051493: regulation of cytoskeleton organization
GO:0060397: JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0070498: interleukin-1-mediated signaling pathway
GO:0070849: response to epidermal growth factor stimulus
GO:0072584: caveolin-mediated endocytosis
GO:0090170: regulation of Golgi inheritance
GO:2000641: regulation of early endosome to late endosome transport
GO:2000657: negative regulation of apolipoprotein binding
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005769: early endosome
GO:0005770: late endosome
GO:0005794: Golgi apparatus
GO:0005856: cytoskeleton
GO:0005901: caveola
GO:0005925: focal adhesion
GO:0015630: microtubule cytoskeleton
GO:0031143: pseudopodium
GO:0005515: protein binding
GO:0001784: phosphotyrosine binding
GO:0004707: MAP kinase activity
GO:0005524: ATP binding
GO:0019902: phosphatase binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4114: Oocyte meiosis
4150: mTOR signaling pathway
4270: Vascular smooth muscle contraction
4320: Dorso-ventral axis formation
4350: TGF-beta signaling pathway
4360: Axon guidance
4370: VEGF signaling pathway
4380: Osteoclast differentiation
4510: Focal adhesion
4520: Adherens junction
4540: Gap junction
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4666: Fc gamma R-mediated phagocytosis
4720: Long-term potentiation
4722: Neurotrophin signaling pathway
4730: Long-term depression
4810: Regulation of actin cytoskeleton
4910: Insulin signaling pathway
4912: GnRH signaling pathway
4914: Progesterone-mediated oocyte maturation
4916: Melanogenesis
4930: Type II diabetes mellitus
4960: Aldosterone-regulated sodium reabsorption
5010: Alzheimer's disease
5020: Prion diseases
5131: Shigellosis
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5160: Hepatitis C
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5216: Thyroid cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5223: Non-small cell lung cancer

PubMed abstracts associated with MAPK3

PMID Title Tumor Value
9100584 Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells. no no
10234573 ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. no no
12388161 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. no no
15144225 Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. no no
15268905 Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation. no no
16007340 Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. no no
16470222 RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. no no
16814113 Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. no no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
17323424 Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. no no
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no
17513610 Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. no no
18332870 Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. no no
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
18986328 Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. no no
19212684 The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. yes yes
19393247 Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. no no
20003259 Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. yes no
20406948 Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. no no
20460760 Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. no no
20592496 Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. no no
21236332 15-Deoxy-?12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. no no
21440986 Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. no no
21667022 The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. no no
22179790 RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro. no no
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
22525461 Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. yes no
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no
22688575 Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. no no
22935974 Mitogen-activated protein kinase pathway in osteosarcoma. yes yes
22993301 Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-?B and MAPK pathways. no no
22849560 Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. no no
23201449 Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. no no
23262982 Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. no no
23507142 miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. yes no
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